scholarly journals A GC–MS Method for Detection and Quantification of Cathine, Cathinone, Methcathinone and Ephedrine in Oral Fluid

2016 ◽  
Vol 54 (8) ◽  
pp. 1271-1276 ◽  
Author(s):  
Khaled M. Mohamed ◽  
Abtehaj H. Al-Hazmi ◽  
Alanoud M. Alasiri ◽  
Mahmoud El-Said Ali
Keyword(s):  
Oral Fluid ◽  
Detection And Quantification

scholarly journals New Method for the Monitoring of Antidepressants in Oral Fluid Using Dried Spot Sampling

2021 ◽  
Vol 14 (12) ◽  
pp. 1284
Author(s):  
Sofia Soares ◽  
Tiago Rosado ◽  
Mário Barroso ◽  
Eugenia Gallardo
Keyword(s):  
Oral Fluid ◽  
Forensic Toxicology ◽  
Public Health Problem ◽  
Tandem Mass ◽  
Depression And Anxiety ◽  
Coefficients Of Variation ◽  
Precision And Accuracy ◽  
Relative Errors ◽  
Clinical And Forensic Toxicology ◽  
Detection And Quantification

The increase in the consumption of antidepressants is a public health problem worldwide, as these are a class of compounds widely used in the treatment of several illnesses, such as depression and anxiety. This work aimed to develop and optimize a method for the quantification of a number of antidepressants and their metabolites (fluoxetine, venlafaxine, O-desmethylvenlafaxine, citalopram, sertraline, and paroxetine) in 100 µL of oral fluid using the dried saliva spots (DSS) sampling approach and gas chromatography coupled with tandem mass spectrometry (GC–MS/MS). The method was validated, presenting linearity within the studied range, with detection and quantification limits ranging between 10 and 100 ng/mL, and coefficients of determination (R2) of at least 0.99 for all analytes. Recoveries were between approximately 13 and 46%. The analysis of precision and accuracy presented acceptable coefficients of variation and relative errors, considering the criteria usually accepted in the validation of bioanalytical procedures. The method herein described is the first to be reported using DSS for the extraction of antidepressants, proving to be a sensitive, simple, and fast alternative to conventional techniques, and capable of being routinely applied in clinical and forensic toxicology scenarios.

scholarly journals Thermographic detection and quantification of THC in oral fluid at unprecedented low concentrations

2020 ◽  
Vol 11 (4) ◽  
pp. 2178 ◽  
Author(s):  
Damber Thapa ◽  
Nakisa Samadi ◽  
Nisarg Patel ◽  
Nima Tabatabaei
Keyword(s):  
Oral Fluid ◽  
Low Concentrations ◽  
Detection And Quantification

Oral fluid as an alternative matrix for Therapeutic Drug Monitoring

2017 ◽  
Author(s):  
H Clement ◽  
J Preiskorn ◽  
S Studer ◽  
K Ebert ◽  
E Maurice ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Oral Fluid ◽  
Therapeutic Drug

INFLUENCE OF OFFICE BLEACHING SYSTEMS ON THE RESISTANCE OF HARD TOOTH TISSUES

2020 ◽  
pp. 119-125
Author(s):  
Magsumova O.A. ◽  
Postnikov M.A. ◽  
Ryskina E.A. ◽  
Tkach T.M. ◽  
Polkanova V.A.
Keyword(s):  
Informed Consent ◽  
Oral Fluid ◽  
Personal Data ◽  
Acid Resistance ◽  
Non Invasive ◽  
Hard Tissues ◽  
Voluntary Informed Consent

One of the non-invasive methods for treating discoloration of hard tooth tissues is teeth whitening. The aim of this work is to assess the dynamics of changes in the acid resistance of enamel and hard tissues of teeth and the rate of its remineralization after the procedure of office teeth whitening. The study involved 123 patients aged 18 to 35 years with discoloration of various origins, with the color of hard tooth tissues on the Vita Classic A2 scale and darker. Before performing the office, teeth whitening procedure, all patients gave their written voluntary informed consent to participate in this study, as well as consent to the processing of personal data. Depending on the chosen method of office teeth whitening, patients were divided into 3 groups. The resistance of hard tooth tissues was judged based on the determination of TOER and CASRE tests. These indicators were determined at various times (5 days before the office teeth whitening procedure, 5 days after it, after 14, 30 days and 6 months). Regardless of the chosen whitening system, the office teeth whitening procedure is accompanied by a decrease in the enamel's resistance to acids and a decrease in the rate of its remineralization. The remineralizing function of oral fluid promotes the positive dynamics of the studied parameters after 14 days and after 30 days values increased due to the appointment of remineralizing therapy to all patients in 2 weeks after the teeth whitening procedure. After 6 months, all patients had high enamel resistance and the rate of its remineralization.

Sign in / Sign up

Export Citation Format

Share Document