scholarly journals Simultaneous Determination of Eight Chemicals in Fufang Xueshuantong Capsules by LC–MS-MS with Periodic Polarity Switching

2015 ◽  
Vol 53 (10) ◽  
pp. 1757-1764 ◽  
Author(s):  
Chunhua Zhou ◽  
Linfei Su ◽  
Weiding Shang ◽  
Zhihuan Rong ◽  
Mengmeng Sun ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Polarity Switching

scholarly journals Simultaneous determination of tryptophan and its 31 catabolites in mouse tissues by polarity switching UHPLC-SRM-MS

2018 ◽  
Vol 1037 ◽  
pp. 200-210 ◽  
Author(s):  
Guan-yuan Chen ◽  
Wei Zhong ◽  
Zhanxiang Zhou ◽  
Qibin Zhang
Keyword(s):  
Simultaneous Determination ◽  
Mouse Tissues ◽  
Polarity Switching

scholarly journals Simultaneous Determination of a Novel PD-L1 Inhibitor, IMMH-010, and Its Active Metabolite, YPD-29B, in Rat Biological Matrices by Polarity-Switching Liquid Chromatography-Tandem Mass Spectrometry: Application to ADME Studies

2021 ◽  
Vol 12 ◽  
Author(s):  
Jianwei Jiang ◽  
Xiaowen Zou ◽  
Yuke Liu ◽  
Xiao Liu ◽  
Kai Dong ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Active Metabolite ◽  
Rat Plasma ◽  
Limit Of Quantification ◽  
Clinical Trial Registration ◽  
Time Curve ◽  
Polarity Switching ◽  
Liquid Chromatography Tandem Mass ◽  
Further Development

IMMH-010 is a prodrug of YPD-29B, which is a novel PD-L1 inhibitor. A specific and sensitive LC-MS/MS method with polarity switching was developed and validated for the simultaneous determination of IMMH-010 and YPD-29B in rat plasma, liver, brain, urine and fecal samples. Method validation was investigated to demonstrate the lower limit of quantification linearity, precision and accuracy, matrix effect and recovery, stability and dilution reliability for IMMH-010 and YPD-29B. This validated method was successfully applied to investigate the pharmacokinetics, tissue distribution, and excretion of IMMH-010 and YPD-29B in rats. After oral administration of IMMH-010 maleate to rats, IMMH-010 was rapidly and extensively converted to the active metabolite YPD-29B. The areas under the plasma concentration-time curve (AUC) of IMMH-010 and YPD-29B were proportional to the dose in the range of 10–100 mg/kg. IMMH-010 was primarily distributed in the adrenal gland, lymph nodes, heart, liver and spleen. YPD-29B was mainly observed in the liver, lymph, kidney, and lung. Approximately 28.81% of the IMMH-010 dose was recovered in the urine and feces within 72 h, including unchanged IMMH-010 (7.99%) and YPD-29B (20.82%). The results of this study may be useful as a reference for further development of IMMH-010 and PD-L1 inhibitors.Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT04343859?term=IMMH-010&draw=2&rank=1], identifier [NCT04343859]."

A general computer program for the extended plate overlap algorithm

1978 ◽  
Vol 48 ◽  
pp. 287-293 ◽  
Author(s):  
Chr. de Vegt ◽  
E. Ebner ◽  
K. von der Heide
Keyword(s):  
Computer Program ◽  
Simultaneous Determination ◽  
General Computer Program ◽  
General Computer

In contrast to the adjustment of single plates a block adjustment is a simultaneous determination of all unknowns associated with many overlapping plates (star positions and plate constants etc. ) by one large adjustment. This plate overlap technique was introduced by Eichhorn and reviewed by Googe et. al. The author now has developed a set of computer programmes which allows the adjustment of any set of contemporaneous overlapping plates. There is in principle no limit for the number of plates, the number of stars, the number of individual plate constants for each plate, and for the overlapping factor.

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