scholarly journals A Stability-Indicating Reversed-Phase High-Performance Liquid Chromatography Method for Ambrisentan: An Endothelin Receptor Antagonist

2013 ◽  
Vol 52 (8) ◽  
pp. 894-898 ◽  
Author(s):  
N. Satheeshkumar ◽  
G. Naveenkumar
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Receptor Antagonist ◽  
High Performance ◽  
Reversed Phase ◽  
Endothelin Receptor Antagonist ◽  
Endothelin Receptor ◽  
Chromatography Method ◽  
Stability Indicating ◽  
Liquid Chromatography Method

scholarly journals Development and Validation of Stability-Indicating Assay Method by RP-HPLC for Simultaneous Estimation of Rosuvastatin Calcium and Fenofibrate in Pharmaceutical Dosage Form

2020 ◽  
Vol 10 (4) ◽  
pp. 79-86
Author(s):  
Awdhut Pimpale ◽  
Rajendra Kakde
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Reversed Phase ◽  
Simultaneous Estimation ◽  
Chromatography Method ◽  
Stability Indicating ◽  
Rp Hplc ◽  
Liquid Chromatography Method ◽  
Rosuvastatin Calcium

A Simple, precise, and accurate stability-indicating reversed-phase high-performance liquid chromatography method has been established for the simultaneous estimation of rosuvastatin calcium and fenofibrate in combined bulk and tablet formulation. The chromatographic separation was performed on reverse phase Princeton (C18) (250 mm x 4.6 mm, 5µ) column with mobile phase as a mixture of water (pH adjusted to 3.0 with orthophosphoric acid) and acetonitrile in the ratio (40:60) v/v at the flow rate 1.0 ml/min. Detection was carried out at wavelength 240 nm. The retention time under the optimized condition of Rosuvastatin calcium and Fenofibrate was found to be 2.485 & 3.905 minutes respectively. The calibration curve was linear in the range of 6-16 µg/ml and 87-232 µg/ml for rosuvastatin calcium and fenofibrate with a correlation coefficient of 0.9999 and 0.9994 respectively. Relative standard deviation values for all key parameters were less than 2.0%. The percentage recovery was found to be 99.66-100.37% and 99.13-100.44% for rosuvastatin calcium and fenofibrate respectively. The developed reversed-phase high-performance liquid chromatography method was found to be simple, specific, sensitive, rapid, linear, accurate, precise, and economical, and could be used for regular quality control of rosuvastatin calcium and fenofibrate in bulk and tablet formulations.  Keywords: Rosuvastatin calcium, Fenofibrate, RP-HPLC, Method validation, ICH guidelines.

Hydrolytic Degradation Kinetic Study of Balofloxacin by Stability Indicating Reversed Phase High Performance Liquid Chromatography Method

2016 ◽  
Vol 7 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Bhavin Pankajbhai Marolia ◽  
Pintu Bhagwanbhai Prajapati ◽  
Kunjan Bharatbhai Bodiwala ◽  
Megha Pravinkumar Vaghela ◽  
Shailesh Amritlal Shah ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Kinetic Study ◽  
High Performance ◽  
Hydrolytic Degradation ◽  
Reversed Phase ◽  
Chromatography Method ◽  
Degradation Kinetic ◽  
Stability Indicating ◽  
Liquid Chromatography Method

scholarly journals A stability-indicating high performance liquid chromatography method to determine apocynin in nanoparticles

2017 ◽  
Vol 7 (2) ◽  
pp. 129-133 ◽  
Author(s):  
Juliana Kovalczuk de Oliveira ◽  
Débora Fernanda Veres Ronik ◽  
Jociani Ascari ◽  
Rubiana Mara Mainardes ◽  
Najeh Maissar Khalil
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Chromatography Method ◽  
Stability Indicating ◽  
Liquid Chromatography Method

Reversed-phase high performance liquid chromatography method for the determination of paraquat in whole blood

2014 ◽  
Vol 6 (16) ◽  
pp. 6560-6564 ◽  
Author(s):  
Wuxiang Zhang ◽  
Yicong Su ◽  
Jiangu Shi ◽  
Maosheng Zhang ◽  
Bide Wu ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Whole Blood ◽  
High Performance ◽  
Reversed Phase ◽  
Chromatography Method ◽  
Liquid Chromatography Method

In this paper, a high performance liquid chromatography technique is established for quantification of paraquat in blood.

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