scholarly journals UPLC and LC-MS Studies on Degradation Behavior of Irinotecan Hydrochloride and Development of a Validated Stability-Indicating Ultra-Performance Liquid Chromatographic Method for Determination of Irinotecan Hydrochloride and its Impurities in Pharmaceutical Dosage Forms

2012 ◽  
Author(s):  
N. Kumar ◽  
D. Sangeetha ◽  
S. P. Reddy
Keyword(s):  
Chromatographic Method ◽  
Dosage Forms ◽  
Degradation Behavior ◽  
Pharmaceutical Dosage Forms ◽  
Irinotecan Hydrochloride ◽  
Stability Indicating ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

scholarly journals Development and Validation of a Liquid Chromatographic Method for Fexofenadine Hydrochloride in Capsules

2004 ◽  
Vol 87 (5) ◽  
pp. 1093-1097 ◽  
Author(s):  
Ana R Breier ◽  
Clésio S Paim ◽  
Júulia Menegola ◽  
Martin Steppe ◽  
Elfrides E S Schapoval ◽  
...  
Keyword(s):  
Chromatographic Method ◽  
Ammonium Acetate ◽  
Allergic Diseases ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Liquid Chromatographic Method ◽  
Relative Standard ◽  
Development And Validation ◽  
Liquid Chromatographic

Abstract This paper describes the development and validation of a new, simple, fast, and sensitive liquid chromatographic method for the determination of the antihistamine fexofenadine. Although widely used in the treatment of allergic diseases, fexofenadine is not listed in any pharmacopeia, and there are few methods in the literature for its quantitation in pharmaceutical dosage forms. In this work, a LiChrospher® 100 RP-18 (250 × 4.0 mm, 5 μm) column was used as the stationary phase, and acetonitrile–5mM ammonium acetate buffer (50 + 50, v/v) at pH 3.2 was the mobile phase. Through the evaluation of the analytical parameters, it was shown that the method is linear (r = 0.9999) at concentrations ranging from 20.0 to 80.0 μg/mL, precise (intraday relative standard deviation [RSD] values = 0.85, 0.40, and 0.81%; interday RSD = 0.77%), accurate (mean recovery = 99.05%), specific, and robust. The detection and quantitation limits are 0.3409 and 1.033 μg/mL, respectively. These low values show the good sensitivity of the proposed method.

Liquid Chromatographic Method for Perphenazine and Its Sulfoxide in Pharmaceutical Dosage Forms for Determination of Stability

1986 ◽  
Vol 69 (1) ◽  
pp. 167-169
Author(s):  
Normand Beaulieu ◽  
Edward G Lovering
Keyword(s):  
Chromatographic Method ◽  
Dosage Forms ◽  
Expiration Date ◽  
Pharmaceutical Dosage Forms ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

Abstract A liquid chromatographic method is described for determination of perphenazine and perphenazine sulfoxide in representative dosage forms. Sulfoxide levels were nondetectable or less than 1% in tablets and in an injectable product. Sulfoxide levels increase with time in some syrup formulations and may be as high as 11% in syrup formulations before their expiration date.

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