scholarly journals An HPLC Method for the Determination of Bisoprolol in Human Plasma and its Application to a Pharmacokinetic Study

2012 ◽  
Vol 50 (7) ◽  
pp. 615-619 ◽  
Author(s):  
S. Tatar Ulu ◽  
Z. Aydogmus
Keyword(s):  
Human Plasma ◽  
Pharmacokinetic Study ◽  
Hplc Method

Simple and sensitive HPLC method for determination of amrubicin and amrubicinol in human plasma: application to a clinical pharmacokinetic study

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Reiko Ando ◽  
Yoshinori Makino ◽  
Tomohide Tamura ◽  
Noboru Yamamoto ◽  
Rena Nishigaki ◽  
...  
Keyword(s):  
Human Plasma ◽  
Clinical Pharmacokinetic ◽  
Pharmacokinetic Study ◽  
Hplc Method

scholarly journals Validation of an HPLC Method for Determination of Pentoxifylline in Human Plasma and Its Application to Pharmacokinetic Study

2009 ◽  
Vol 92 (3) ◽  
pp. 837-845 ◽  
Author(s):  
Pattana Sripalakit ◽  
Aurasorn Saraphanchotiwitthaya
Keyword(s):  
Human Plasma ◽  
Pharmacokinetic Study ◽  
Limit Of Detection ◽  
Solid Phase ◽  
Internal Standard ◽  
Hplc Method ◽  
Dose Administration ◽  
Limit Of Quantitation ◽  
Interday Precision

Abstract An HPLC method suitable for routine determination of pentoxifylline in human plasma has been adapted and validated. Sample preparation was done by solid-phase extraction. Chloramphenicol was used as the internal standard. The linear range was from 15400 ng/mL (r2 = 0.9994), with a limit of quantitation of 15 ng/mL. The limit of detection was found to be 5 ng/mL. The intra- and interday accuracy ranged from 98.0 to 110.2 and the coefficient of variation was not more than 8.8 for both intra- and interday precision. The absolute recoveries of pentoxifylline and chloramphenicol from human plasma were >97. The method was validated with excellent specificity, accuracy, precision, recovery, and stability. The pharmacokinetic study of a generic pentoxifylline 400 mg tablet in healthy Thai male volunteers after a single dose administration was determined by this developed assay.

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