scholarly journals In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies

2019 ◽  
Author(s):  
Alexander D Shaw ◽  
Laura E Hughes ◽  
Rosalyn Moran ◽  
Ian Coyle-Gilchrist ◽  
Tim Rittman ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Experimental Medicine ◽  
In Vivo Assay

scholarly journals In vivo assay of cortical microcircuitry in frontotemporal dementia: a platform for experimental medicine studies

2018 ◽  
Author(s):  
Alexander D Shaw ◽  
Laura E Hughes ◽  
Rosalyn Moran ◽  
Ian Coyle-Gilchrist ◽  
Tim Rittman ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Neural Circuits ◽  
Case Control ◽  
Experimental Medicine ◽  
Non Invasive ◽  
Cortical Responses ◽  
Sensory Predictions ◽  
Local Coupling ◽  
Laminar Specificity

AbstractThe analysis of neural circuits can provide critical insights into the mechanisms of neurodegeneration and dementias, and offer potential quantitative biological tools to assess novel therapeutics. Here we use behavioural variant frontotemporal dementia (bvFTD) as a model disease. We demonstrate that inversion of canonical microcircuit models to non-invasive human magnetoecphalography can identify the regional- and laminar-specificity of bvFTD pathophysiology, and their parameters can accurately differentiate patients from matched healthy controls. Using such models, we show that changes in local coupling in frontotemporal dementia underlie the failure to adequately establish sensory predictions, leading to altered prediction error responses in a cortical information-processing hierarchy. Using machine learning, this model-based approach provided greater case-control classification accuracy than conventional evoked cortical responses. We suggest that this approach provides an in vivo platform for testing mechanistic hypotheses about disease progression and pharmacotherapeutics.

scholarly journals In vivo exploration of synaptic projections in frontotemporal dementia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eric Salmon ◽  
Mohamed Ali Bahri ◽  
Alain Plenevaux ◽  
Guillaume Becker ◽  
Alain Seret ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Input Function ◽  
Parahippocampal Gyrus ◽  
Exploratory Research ◽  
Social Brain ◽  
Synaptic Density ◽  
Clinical Disorder ◽  
Significant Difference ◽  
The Right

AbstractThe purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections was assessed with [18F]UCBH-PET. Total distribution volume was obtained with Logan method using carotid artery derived input function. Neuroimages were analyzed with SPM12. Verbal fluency, episodic memory and awareness of cognitive impairment were equally impaired in patients groups. Compared to controls, [18F]UCBH uptake tended to decrease in the right anterior parahippocampal gyrus of bvFTD patients. Loss of synaptic projections was observed in the right hippocampus of AD participants, but there was no significant difference in [18F]UCBH brain uptake between patients groups. Anosognosia for clinical disorder was correlated with synaptic density in the caudate nucleus and the anteromedial prefrontal cortex. This study suggests that synaptopathy in bvFTD targets the temporal social brain and self-referential processes.

Evaluation of the Skin Sensitization Potential of Silica nanoparticles using in vitro and in vivo assay

2021 ◽  
Vol 350 ◽  
pp. S72
Author(s):  
D.H. Lee ◽  
S.-H. Kim ◽  
J.H. Lee ◽  
J.-Y Yang ◽  
H.-S. Shin ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Skin Sensitization ◽  
In Vivo Assay

In vivo assay of nitrate reductase in tea (Camellia sinensis L.) leaf and root

1987 ◽  
Vol 41 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Tarun Ch. Sarmah ◽  
Mahinath Dev Choudhury ◽  
Monoranjan Goswami
Keyword(s):  
Nitrate Reductase ◽  
Camellia Sinensis ◽  
In Vivo Assay
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