scholarly journals Short-Term Memory Depends on Dissociable Medial Temporal Lobe Regions in Amnestic Mild Cognitive Impairment

2015 ◽  
Vol 26 (5) ◽  
pp. 2006-2017 ◽  
Author(s):  
Sandhitsu R. Das ◽  
Lauren Mancuso ◽  
Ingrid R. Olson ◽  
Steven E. Arnold ◽  
David A. Wolk
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Short Term Memory ◽  
Amnestic Mild Cognitive Impairment ◽  
Short Term ◽  
Term Memory

Short-Term Memory Binding Distinguishing Amnestic Mild Cognitive Impairment from Healthy Aging: A Machine Learning Study

2021 ◽  
pp. 1-14
Author(s):  
Juan F. Martínez-Florez ◽  
Juan D. Osorio ◽  
Judith C. Cediel ◽  
Juan C. Rivas ◽  
Ana M. Granados-Sánchez ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Diagnosis ◽  
Short Term Memory ◽  
Amnestic Mild Cognitive Impairment ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding ◽  
Feature Importance

Background: Amnestic mild cognitive impairment (aMCI) is the most common preclinical stage of Alzheimer’s disease (AD). A strategy to reduce the impact of AD is the early aMCI diagnosis and clinical intervention. Neuroimaging, neurobiological, and genetic markers have proved to be sensitive and specific for the early diagnosis of AD. However, the high cost of these procedures is prohibitive in low-income and middle-income countries (LIMCs). The neuropsychological assessments currently aim to identify cognitive markers that could contribute to the early diagnosis of dementia. Objective: Compare machine learning (ML) architectures classifying and predicting aMCI and asset the contribution of cognitive measures including binding function in distinction and prediction of aMCI. Methods: We conducted a two-year follow-up assessment of a sample of 154 subjects with a comprehensive multidomain neuropsychological battery. Statistical analysis was proposed using complete ML architectures to compare subjects’ performance to classify and predict aMCI. Additionally, permutation importance and Shapley additive explanations (SHAP) routines were implemented for feature importance selection. Results: AdaBoost, gradient boosting, and XGBoost had the highest performance with over 80%success classifying aMCI, and decision tree and random forest had the highest performance with over 70%success predictive routines. Feature importance points, the auditory verbal learning test, short-term memory binding tasks, and verbal and category fluency tasks were used as variables with the first grade of importance to distinguish healthy cognition and aMCI. Conclusion: Although neuropsychological measures do not replace biomarkers’ utility, it is a relatively sensitive and specific diagnostic tool for aMCI. Further studies with ML must identify cognitive performance that differentiates conversion from average MCI to the pathological MCI observed in AD.

Face Short-Term Memory-Related Electroencephalographic Patterns can Differentiate Multi- versus Single-Domain Amnestic Mild Cognitive Impairment

2011 ◽  
Vol 26 (1) ◽  
pp. 157-169 ◽  
Author(s):  
Marie-Pierre Deiber ◽  
Vicente Ibáñez ◽  
François Herrmann ◽  
Cristelle Rodriguez ◽  
Joan Emch ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Short Term Memory ◽  
Amnestic Mild Cognitive Impairment ◽  
Single Domain ◽  
Short Term ◽  
Term Memory

scholarly journals Atrophy and cognitive profiles in older adults with temporal lobe epilepsy are similar to mild cognitive impairment

Brain ◽  
2020 ◽  
Author(s):  
Erik Kaestner ◽  
Anny Reyes ◽  
Austin Chen ◽  
Jun Rao ◽  
Anna Christina Macari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Late Onset ◽  
Amnestic Mild Cognitive Impairment

Abstract Epilepsy incidence and prevalence peaks in older adults yet systematic studies of brain ageing and cognition in older adults with epilepsy remain limited. Here, we characterize patterns of cortical atrophy and cognitive impairment in 73 older adults with temporal lobe epilepsy (>55 years) and compare these patterns to those observed in 70 healthy controls and 79 patients with amnestic mild cognitive impairment, the prodromal stage of Alzheimer’s disease. Patients with temporal lobe epilepsy were recruited from four tertiary epilepsy surgical centres; amnestic mild cognitive impairment and control subjects were obtained from the Alzheimer’s Disease Neuroimaging Initiative database. Whole brain and region of interest analyses were conducted between patient groups and controls, as well as between temporal lobe epilepsy patients with early-onset (age of onset <50 years) and late-onset (>50 years) seizures. Older adults with temporal lobe epilepsy demonstrated a similar pattern and magnitude of medial temporal lobe atrophy to amnestic mild cognitive impairment. Region of interest analyses revealed pronounced medial temporal lobe thinning in both patient groups in bilateral entorhinal, temporal pole, and fusiform regions (all P < 0.05). Patients with temporal lobe epilepsy demonstrated thinner left entorhinal cortex compared to amnestic mild cognitive impairment (P = 0.02). Patients with late-onset temporal lobe epilepsy had a more consistent pattern of cortical thinning than patients with early-onset epilepsy, demonstrating decreased cortical thickness extending into the bilateral fusiform (both P < 0.01). Both temporal lobe epilepsy and amnestic mild cognitive impairment groups showed significant memory and language impairment relative to healthy control subjects. However, despite similar performances in language and memory encoding, patients with amnestic mild cognitive impairment demonstrated poorer delayed memory performances relative to both early and late-onset temporal lobe epilepsy. Medial temporal lobe atrophy and cognitive impairment overlap between older adults with temporal lobe epilepsy and amnestic mild cognitive impairment highlights the risks of growing old with epilepsy. Concerns regarding accelerated ageing and Alzheimer’s disease co-morbidity in older adults with temporal lobe epilepsy suggests an urgent need for translational research aimed at identifying common mechanisms and/or targeting symptoms shared across a broad neurological disease spectrum.

P2-317: WHEN IS SHORT-TERM MEMORY BINDING SELECTIVELY IMPAIRED IN MILD COGNITIVE IMPAIRMENT?

2016 ◽  
Vol 12 ◽  
pp. P761-P761 ◽  
Author(s):  
Mario Alfredo Parra ◽  
Sara Fernandez Guinea ◽  
Lidia Sanchez ◽  
Beatriz Suarez ◽  
Anna Frank ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding

scholarly journals Visual short-term memory for high resolution associations is impaired in patients with medial temporal lobe damage

Hippocampus ◽  
2016 ◽  
Vol 27 (2) ◽  
pp. 184-193 ◽  
Author(s):  
Joshua D. Koen ◽  
Alyssa A. Borders ◽  
Michael T. Petzold ◽  
Andrew P. Yonelinas
Keyword(s):  
High Resolution ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory

Long-term versus short-term memory deficits for faces in temporal lobe and generalized epilepsy patients

2010 ◽  
Vol 16 (3) ◽  
pp. 574-578 ◽  
Author(s):  
KIRSTEN HÖTTING ◽  
TALL KATZ-BILETZKY ◽  
THOMAS MALINA ◽  
MATTHIAS LINDENAU ◽  
THOMAS BENGNER
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Short Term Memory ◽  
Memory Systems ◽  
Long Term Memory ◽  
Healthy Controls ◽  
Short Term ◽  
Term Memory ◽  
Generalized Epilepsy

AbstractIt is still an open question whether short-term and long-term memory are two anatomically dissociable memory systems working in parallel or whether they are represented by neural circuits within similar cortical areas. Epilepsy may be used as a model to study these memory processes. We hypothesized that a double dissociation of short-term and long-term memory exists in temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE). Immediate and 24-hour face recognition was tested in 10 TLE patients, 9 IGE patients, and 10 healthy controls. TLE patients’ immediate recognition was unimpaired, but their memory scores were reduced as compared to healthy controls after 24 hours. In IGE patients, memory was already reduced during immediate recognition. These results are in line with the idea that short-term memory is a transient trace that requires consolidation supported by the medial temporal lobe to change into a more stable status of long-term memory. (JINS, 2010, 16, 574–578.)

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