scholarly journals Age-Related Changes to Layer 3 Pyramidal Cells in the Rhesus Monkey Visual Cortex

2013 ◽  
Vol 25 (6) ◽  
pp. 1454-1468 ◽  
Author(s):  
J. I. Luebke ◽  
M. Medalla ◽  
J. M. Amatrudo ◽  
C. M. Weaver ◽  
J. L. Crimins ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Rhesus Monkey ◽  
Pyramidal Cells ◽  
Age Related ◽  
Monkey Visual Cortex ◽  
Age Related Changes

scholarly journals Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates

2021 ◽  
Vol 13 ◽  
Author(s):  
Shannon N. Leslie ◽  
Jean Kanyo ◽  
Dibyadeep Datta ◽  
Rashaun S. Wilson ◽  
Caroline Zeiss ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Significant Risk ◽  
Natural Aging ◽  
Pyramidal Cells ◽  
Significant Risk Factor ◽  
Tau Phosphorylation ◽  
Single Shot ◽  
Age Related ◽  
Liquid Chromatography Tandem Mass ◽  
Age Related Changes

Age is the most significant risk factor for Alzheimer’s disease (AD), and understanding its role in specific aspects of AD pathology will be critical for therapeutic development. Neurofibrillary tangles composed of hyperphosphorylated tau are a quintessential hallmark of AD. To study age-related changes in tau phosphorylation, we developed a simple, antibody-free approach for single shot analysis of tau phosphorylation across the entire protein by liquid-chromatography tandem mass spectrometry. This methodology is species independent; thus, while initially developed in a rodent model, we utilized this technique to analyze 36 phosphorylation sites on rhesus monkey tau from the prefrontal cortex (PFC), a region vulnerable to AD-linked degeneration. Data are available via ProteomeXchange with identifier PXD027971. We identified novel, age-related changes in tau phosphorylation in the rhesus monkey PFC and analyzed patterns of phosphorylation change across domains of the protein. We confirmed a significant increase and positive correlation with age of phosphorylated serine 235 tau and phosphorylated serine 396 tau levels in an expanded cohort of 14 monkeys. Histology showed robust labeling for tau phosphorylated at these sites in vulnerable layer III pyramidal cells in the PFC. The results presented in this study suggest an important role of the natural aging process in tau phosphorylation in rhesus monkey.

Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey

1995 ◽  
Vol 16 (6) ◽  
pp. 939-946 ◽  
Author(s):  
Greg A. Gerhardt ◽  
Wayne A. Cass ◽  
Michael Henson ◽  
Zhiming Zhang ◽  
Aliza Ovadia ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Age Related ◽  
Age Related Changes

scholarly journals Population receptive field tuning properties of visual cortex during childhood

2017 ◽  
Author(s):  
T. M. Dekker ◽  
D.S. Schwarzkopf ◽  
B. de Haas ◽  
M. Nardini ◽  
M.I. Sereno
Keyword(s):  
Visual Cortex ◽  
Receptive Field ◽  
Spatial Information ◽  
Neural Mechanisms ◽  
Neuronal Populations ◽  
Spatial Tuning ◽  
Age Related ◽  
Visuospatial Perception ◽  
Cortical Magnification ◽  
Age Related Changes

AbstractImprovements in visuospatial perception such as contrast sensitivity and Vernier acuity continue until late in childhood, but the neural mechanisms driving these age-related changes are currently unclear. One contributing factor could be the protracted development of spatial tuning of neuronal populations across the visual cortex. Here we tested this possibility using population receptive field (pRF) mapping (Dumoulin and Wandell, 2008) in 6-to 12-year-old children and adults. We fitted pRF models to BOLD signals measured in areas V1-V4 and V3a during fMRI whilst participants watched wedge and ring stimuli traversing the visual field. Cortical magnification and the width of pRF tuning functions changed with viewing eccentricity in all participants. However, there were no age-related changes in pRF size, shape, cortical magnification, or map consistency across any of the visual areas measured. These results suggest that visuospatial perception in late childhood beyond age 6 years is not substantially limited by low-level spatial tuning properties of neuronal populations in visual cortex. Instead, performance improvements in this period may reflect more efficient use of the spatial information available in the visual system when forming perceptual judgments. These findings are an important step towards disentangling which neural mechanisms contribute to the eventual emergence of mature spatial vision, and for understanding the processes that determine the scope for visual plasticity at different stages of life.

scholarly journals Age-related changes in the visual cortex

2002 ◽  
Vol 42 (6) ◽  
pp. 695-703 ◽  
Author(s):  
J.R Mendelson ◽  
E.F Wells
Keyword(s):  
Visual Cortex ◽  
Age Related ◽  
Age Related Changes

AMPA GluR2 subunit is differentially distributed on GABAergic neurons and pyramidal cells in the macaque monkey visual cortex

2001 ◽  
Vol 921 (1-2) ◽  
pp. 60-67 ◽  
Author(s):  
Yong He ◽  
Patrick R Hof ◽  
William G.M Janssen ◽  
Prabhakar Vissavajjhala ◽  
John H Morrison
Keyword(s):  
Visual Cortex ◽  
Pyramidal Cells ◽  
Macaque Monkey ◽  
Gabaergic Neurons ◽  
Monkey Visual Cortex

scholarly journals Age-related changes in the attentional control of visual cortex: A selective problem in the left visual hemifield

2011 ◽  
Vol 49 (7) ◽  
pp. 1670-1678 ◽  
Author(s):  
Lindsay S. Nagamatsu ◽  
Patrick Carolan ◽  
Teresa Y.L. Liu-Ambrose ◽  
Todd C. Handy
Keyword(s):  
Visual Cortex ◽  
Attentional Control ◽  
Visual Hemifield ◽  
Age Related ◽  
Age Related Changes
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