scholarly journals Cortical PKC Inhibition Promotes Axonal Regeneration of the Corticospinal Tract and Forelimb Functional Recovery After Cervical Dorsal Spinal Hemisection in Adult Rats

2013 ◽  
Vol 24 (11) ◽  
pp. 3069-3079 ◽  
Author(s):  
X. Wang ◽  
J. Hu ◽  
Y. She ◽  
G. M. Smith ◽  
X.-M. Xu
Keyword(s):  
Functional Recovery ◽  
Axonal Regeneration ◽  
Corticospinal Tract ◽  
Adult Rats ◽  
Dorsal Spinal ◽  
Spinal Hemisection

DHAM-BMSC Matrix Promotes Axonal Regeneration and Functional Recovery After Spinal Cord Injury in Adult Rats

2009 ◽  
pp. 110306202455053
Author(s):  
Hongsheng Liang ◽  
Peng Liang ◽  
Ye Xu ◽  
Jianing Wu ◽  
Tao Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Adult Rats ◽  
Cord Injury

DHAM-BMSC Matrix Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury in Adult Rats

2009 ◽  
Vol 26 (10) ◽  
pp. 1745-1757 ◽  
Author(s):  
Hongsheng Liang ◽  
Peng Liang ◽  
Ye Xu ◽  
Jianing Wu ◽  
Tao Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Adult Rats ◽  
Cord Injury

scholarly journals The corticospinal tract structure of collagen/silk fibroin scaffold implants using 3D printing promotes functional recovery after complete spinal cord transection in rats

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Xiao-Hong Li ◽  
Xiang Zhu ◽  
Xiao-Yin Liu ◽  
Hai-Huan Xu ◽  
Wei Jiang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
3D Printing ◽  
Silk Fibroin ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Corticospinal Tract ◽  
Axonal Growth ◽  
Spinal Cord Transection ◽  
Silk Fibroin Scaffold ◽  
Cord Injury

AbstractNo effective treatment has been established for nerve dysfunction caused by spinal cord injury (SCI). Orderly axonal growth at the site of spinal cord transection and creation of an appropriate biological microenvironment are important for functional recovery. To axially guiding axonal growth, designing a collagen/silk fibroin scaffold fabricated with 3D printing technology (3D-C/SF) emulated the corticospinal tract. The normal collagen/silk fibroin scaffold with freeze-drying technology (C/SF) or 3D-C/SF scaffold were implanted into rats with completely transected SCI to evaluate its effect on nerve repair during an 8-week observation period. Electrophysiological analysis and locomotor performance showed that the 3D-C/SF implants contributed to significant improvements in the neurogolical function of rats compared to C/SF group. By magnetic resonance imaging, 3D-C/SF implants promoted a striking degree of axonal regeneration and connection between the proximal and distal SCI sites. Compared with C/SF group, rats with 3D-C/SF scaffold exhibited fewer lesions and disordered structures in histological analysis and more GAP43-positive profiles at the lesion site. The above results indicated that the corticospinal tract structure of 3D printing collagen/silk fibroin scaffold improved axonal regeneration and promoted orderly connections within the neural network, which could provided a promising and innovative approach for tissue repair after SCI.

TAT-PEP Enhanced Neurobehavioral Functional Recovery by Facilitating Axonal Regeneration and Corticospinal Tract Projection After Stroke

2016 ◽  
Vol 55 (1) ◽  
pp. 652-667 ◽  
Author(s):  
Bin Deng ◽  
Liya Li ◽  
Xingchun Gou ◽  
Hao Xu ◽  
Zhaohua Zhao ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Axonal Regeneration ◽  
Corticospinal Tract

scholarly journals Nerve-Muscle-Endplate Band Grafting: A New Technique for Muscle Reinnervation

2011 ◽  
Vol 69 (suppl_2) ◽  
pp. ons208-ons224 ◽  
Author(s):  
Liancai Mu ◽  
Stanislaw Sobotka ◽  
Hungxi Su
Keyword(s):  
Functional Recovery ◽  
Axonal Regeneration ◽  
Neuromuscular Junctions ◽  
Force Measurement ◽  
Recovery Period ◽  
Motor Endplate ◽  
Adult Rats ◽  
Nerve Branch ◽  
Muscle Reinnervation ◽  
Nerve Muscle

Abstract BACKGROUND Because currently existing reinnervation methods result in poor functional recovery, there is a great need to develop new treatment strategies. OBJECTIVE To investigate the efficacy of our recently developed nerve-muscle-endplate band grafting (NMEG) technique for muscle reinnervation. METHODS Twenty-five adult rats were used. Sternohyoid (SH) and sternomastoid (SM) muscles served as donor and recipient muscle, respectively. Neural organization of the SH and SM muscles and surgical feasibility of the NMEG technique were determined. An NMEG contained a muscle block, a nerve branch with nerve terminals, and a motor endplate band with numerous neuromuscular junctions. After a 3-month recovery period, the degree of functional recovery was evaluated with a maximal tetanic force measurement. Retrograde horseradish peroxidase tracing was used to track the origin of the motor innervation of the reinnervated muscles. The reinnervated muscles were examined morphohistologically and immunohistochemically to assess the extent of axonal regeneration. RESULTS Nerve supply patterns and locations of the motor endplate bands in the SH and SM muscles were documented. The results demonstrated that the reinnervated SM muscles gained motor control from the SH motoneurons. The NMEG technique yielded extensive axonal regeneration and significant recovery of SM muscle force-generating capacity (67% of control). The mean wet weight of the NMEG-reinnervated muscles (87% of control) was greater than that of the denervated SM muscles (36% of control). CONCLUSION The NMEG technique resulted in successful muscle reinnervation and functional recovery. This technique holds promise in the treatment of muscle paralysis.

scholarly journals Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells

Glia ◽  
2006 ◽  
Vol 53 (4) ◽  
pp. 352-359 ◽  
Author(s):  
Masanori Sasaki ◽  
Bryan C. Hains ◽  
Karen L. Lankford ◽  
Stephen G. Waxman ◽  
Jeffery D. Kocsis
Keyword(s):  
Spinal Cord ◽  
Corticospinal Tract ◽  
Spinal Cord Transection ◽  
Olfactory Ensheathing Cells ◽  
Dorsal Spinal Cord ◽  
Ensheathing Cells ◽  
Dorsal Spinal

scholarly journals Exercise promotes motor functional recovery in rats with corticospinal tract injury: anti-apoptosis mechanism

2015 ◽  
Vol 10 (4) ◽  
pp. 644 ◽  
Author(s):  
Xiao-yu Yang ◽  
Ting-ting Hou ◽  
Peng Xia ◽  
Su Pan ◽  
Jian Liu ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Corticospinal Tract

Survival, regeneration and functional recovery of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion

2004 ◽  
Vol 19 (8) ◽  
pp. 2123-2131 ◽  
Author(s):  
Huai-Yu Gu ◽  
Hong Chai ◽  
Jian-Yi Zhang ◽  
Zhi-Bin Yao ◽  
Li-Hua Zhou ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Ventral Root ◽  
Root Avulsion ◽  
Spinal Root ◽  
Adult Rats

DNA vaccine against NgR promotes functional recovery after spinal cord injury in adult rats

2007 ◽  
Vol 1147 ◽  
pp. 66-76 ◽  
Author(s):  
Panpan Yu ◽  
Lidong Huang ◽  
Jian Zou ◽  
Huiqing Zhu ◽  
Xiaofei Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Dna Vaccine ◽  
Functional Recovery ◽  
Adult Rats ◽  
Cord Injury
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