scholarly journals Macaque Dorsolateral Prefrontal Cortex Does not Suppress Saccade-Related Activity in the Superior Colliculus

2013 ◽  
Vol 24 (5) ◽  
pp. 1373-1388 ◽  
Author(s):  
Kevin Johnston ◽  
Michael J. Koval ◽  
Stephen G. Lomber ◽  
Stefan Everling
Keyword(s):  
Prefrontal Cortex ◽  
Superior Colliculus ◽  
Dorsolateral Prefrontal Cortex ◽  
Related Activity ◽  
Dorsolateral Prefrontal

scholarly journals Dorsolateral Prefrontal Cortex Deactivation in Monkeys Reduces Preparatory Beta and Gamma Power in the Superior Colliculus

2014 ◽  
Vol 25 (12) ◽  
pp. 4704-4714 ◽  
Author(s):  
Jason L. Chan ◽  
Michael J. Koval ◽  
Thilo Womelsdorf ◽  
Stephen G. Lomber ◽  
Stefan Everling
Keyword(s):  
Prefrontal Cortex ◽  
Superior Colliculus ◽  
Dorsolateral Prefrontal Cortex ◽  
Dorsolateral Prefrontal ◽  
Gamma Power

scholarly journals Caudate stimulation enhances learning

Brain ◽  
2019 ◽  
Vol 142 (10) ◽  
pp. 2930-2937 ◽  
Author(s):  
Sarah K Bick ◽  
Shaun R Patel ◽  
Husam A Katnani ◽  
Noam Peled ◽  
Alik Widge ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Associative Learning ◽  
Dorsolateral Prefrontal Cortex ◽  
Neural Circuits ◽  
Memory Disorders ◽  
Related Activity ◽  
Depth Electrodes ◽  
Dorsolateral Prefrontal ◽  
Promising Treatment ◽  
Seizure Localization

Neuromodulation offers the possibility of precise alteration of disordered neural circuits. In patients with depth electrodes implanted for seizure localization, Bick et al. show that caudate stimulation improves associative learning and modulates learning-related activity in dorsolateral prefrontal cortex. Caudate stimulation may be a promising treatment for memory disorders.

Dorsolateral Prefrontal Cortex Enables Updating of Established Memories

2018 ◽  
Vol 29 (10) ◽  
pp. 4154-4168 ◽  
Author(s):  
Lisa Marieke Kluen ◽  
Lisa Catherine Dandolo ◽  
Gerhard Jocham ◽  
Lars Schwabe
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Neural Mechanisms ◽  
Related Activity ◽  
Future Behavior ◽  
New Information ◽  
Dorsolateral Prefrontal ◽  
Increased Activity ◽  
The Brain

Abstract Updating established memories in light of new information is fundamental for memory to guide future behavior. However, little is known about the brain mechanisms by which existing memories can be updated. Here, we combined functional magnetic resonance imaging and multivariate representational similarity analysis to elucidate the neural mechanisms underlying the updating of consolidated memories. To this end, participants first learned face–city name pairs. Twenty-four hours later, while lying in the MRI scanner, participants were required to update some of these associations, but not others, and to encode entirely new pairs. Updating success was tested again 24 h later. Our results showed increased activity of the dorsolateral prefrontal cortex (dlPFC) specifically during the updating of existing associations that was significantly stronger than when simple retrieval or new encoding was required. The updating-related activity of the dlPFC and its functional connectivity with the hippocampus were directly linked to updating success. Furthermore, neural similarity for updated items was markedly higher in the dlPFC and this increase in dlPFC neural similarity distinguished individuals with high updating performance from those with low updating performance. Together, these findings suggest a key role of the dlPFC, presumably in interaction with the hippocampus, in the updating of established memories.

Taste-related activity in the human dorsolateral prefrontal cortex

NeuroImage ◽  
2004 ◽  
Vol 21 (2) ◽  
pp. 781-788 ◽  
Author(s):  
Morten L Kringelbach ◽  
Ivan E.T de Araujo ◽  
Edmund T Rolls
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Related Activity ◽  
Dorsolateral Prefrontal

Task-relevant Output Signals are Sent from Monkey Dorsolateral Prefrontal Cortex to the Superior Colliculus during a Visuospatial Working Memory Task

2009 ◽  
Vol 21 (5) ◽  
pp. 1023-1038 ◽  
Author(s):  
Kevin Johnston ◽  
Stefan Everling
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Superior Colliculus ◽  
Dorsolateral Prefrontal Cortex ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Projection Neurons ◽  
Visuospatial Working Memory ◽  
Cortical Function ◽  
Dorsolateral Prefrontal

Visuospatial working memory is one of the most extensively investigated functions of the dorsolateral prefrontal cortex (DLPFC). Theories of prefrontal cortical function have suggested that this area exerts cognitive control by modulating the activity of structures to which it is connected. Here, we used the oculomotor system as a model in which to characterize the output signals sent from the DLPFC to a target structure during a classical spatial working memory task. We recorded the activity of identified DLPFC–superior colliculus (SC) projection neurons while monkeys performed a memory-guided saccade task in which they were required to generate saccades toward remembered stimulus locations. DLPFC neurons sent signals related to all aspects of the task to the SC, some of which were spatially tuned. These data provide the first direct evidence that the DLPFC sends task-relevant information to the SC during a spatial working memory task, and further support a role for the DLPFC in the direct modulation of other brain areas.

Impact of Expected Reward on Neuronal Activity in Prefrontal Cortex, Frontal and Supplementary Eye Fields and Premotor Cortex

2003 ◽  
Vol 90 (3) ◽  
pp. 1766-1789 ◽  
Author(s):  
Matthew R. Roesch ◽  
Carl R. Olson
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Dorsolateral Prefrontal Cortex ◽  
Premotor Cortex ◽  
Motor Preparation ◽  
Motor Output ◽  
Frontal Eye Field ◽  
Related Activity ◽  
Dorsolateral Prefrontal ◽  
Eye Field

In several regions of the macaque brain, neurons fire during delayed response tasks at a rate determined by the value of the reward expected at the end of the trial. The activity of these neurons might be related either to the internal representation of the appetitive value of the expected reward or to motivation-dependent variations in the monkey's level of motor preparation or motor output. According to the first interpretation, reward-related activity should be most prominent in areas affiliated with the limbic system. According to the second interpretation, it should be most prominent in areas affiliated with the motor system. To distinguish between these alternatives, we carried out single-neuron recording while monkeys performed a memory-guided saccade task in which a visual cue presented early in each trial indicated whether the reward would be large or small. Neuronal activity accompanying task performance was monitored in the dorsolateral prefrontal cortex (PFC), the frontal eye field (FEF), a transitional zone caudal to the frontal eye field (FEF/PM), premotor cortex (PM), the supplementary eye field (SEF), and the rostral part of the supplementary motor area (SMAr). The tendency for neuronal activity to increase after cues that predicted a large reward became progressively stronger in progressively more posterior areas both in the lateral sector of the frontal lobe (PFC < FEF < FEF/PM < PM) and in the medial sector (SEF < SMAr). The very strong reward-related activity of premotor neurons was presumably attributable to the monkey's motivation-dependent level of motor preparation or motor output. This finding points to the need to determine whether reward-related activity in other nonlimbic brain areas, including dorsolateral prefrontal cortex and the dorsal striatum, genuinely represents the value of the expected reward or, alternatively, is related to motivational modulation of motor signals.

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