scholarly journals Functional Regeneration of the ex-vivo Reconstructed Mesocorticolimbic Dopaminergic System

2012 ◽  
Vol 23 (12) ◽  
pp. 2905-2922 ◽  
Author(s):  
E. Dossi ◽  
C. Heine ◽  
I. Servettini ◽  
F. Gullo ◽  
K. Sygnecka ◽  
...  
Keyword(s):  
Dopaminergic System ◽  
Ex Vivo ◽  
Functional Regeneration ◽  
Mesocorticolimbic Dopaminergic System

scholarly journals Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior

2017 ◽  
Vol 37 (4) ◽  
pp. 882-892 ◽  
Author(s):  
Jian-Feng Liu ◽  
Justin N. Siemian ◽  
Robert Seaman ◽  
Yanan Zhang ◽  
Jun-Xu Li
Keyword(s):  
Dopaminergic System ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Mesocorticolimbic Dopaminergic System

scholarly journals The Use of Adenoviral Vectors and Ex Vivo Transduced Neurotransplants: Towards Promotion of Neuroregeneration

2000 ◽  
Vol 9 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Bas Blits ◽  
Paul A. Dijkhuizen ◽  
Wim T. J. M. C. Hermens ◽  
Lisette K. E. Van Esseveldt ◽  
Gerard J. Boer ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Biological Clock ◽  
Adenoviral Vectors ◽  
Neural Cells ◽  
Functional Regeneration ◽  
Growth Promoting ◽  
Ex Vivo Approach ◽  
Potential Use ◽  
Transplantation Model

Regeneration of injured axons following injury depends on a delicate balance between growth-promoting and growth-inhibiting factors. Overexpression of neurotrophin genes seems a promising strategy to promote regeneration. Trophic genes can be overexpressed at the site of injury at the axonal stumps, or at the perikaryal level of the injured neuron. Transduction of the neural cells can be achieved by applying adenoviral vectors, either directly in vivo or—in the case of neurotransplantation—as an ex vivo approach. In both cases it would create a more permissive environment for axonal growth and therefore in functional regeneration. In this article, the feasibility of the use of adenoviral vectors in several neuroregeneration models–-in particularly in spinal cord lesion models and the biological clock transplantation model–-is illustrated. The results show that the adenoviral vectors can be a powerful tool to study the effects of overexpression of genes in an in vivo paradigm of nerve regeneration or nerve outgrowth. The potential use of adenoviral vectors and ex vivo transduced neurotransplants is discussed.

Relatively spared mesocorticolimbic dopaminergic system in juvenile parkinsonism

2007 ◽  
Vol 13 (8) ◽  
pp. 483-488 ◽  
Author(s):  
Nahoko Yoshimura ◽  
Masayuki Yokochi ◽  
Yayoi Kan ◽  
Shinichi Koyama ◽  
Mitsuru Kawamura
Keyword(s):  
Dopaminergic System ◽  
Juvenile Parkinsonism ◽  
Mesocorticolimbic Dopaminergic System

scholarly journals Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior

2016 ◽  
Vol 37 (4) ◽  
pp. 882-892 ◽  
Author(s):  
Jian-Feng Liu ◽  
Justin N. Siemian ◽  
Robert Seaman ◽  
Yanan Zhang ◽  
Jun-Xu Li
Keyword(s):  
Dopaminergic System ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Mesocorticolimbic Dopaminergic System

scholarly journals Imaging cocaine-induced changes in the mesocorticolimbic dopaminergic system of conscious rats

2004 ◽  
Vol 139 (2) ◽  
pp. 167-176 ◽  
Author(s):  
Marcelo Febo ◽  
Annabell C. Segarra ◽  
Jeffrey R. Tenney ◽  
Mathew E. Brevard ◽  
Timothy Q. Duong ◽  
...  
Keyword(s):  
Dopaminergic System ◽  
Conscious Rats ◽  
Induced Changes ◽  
Mesocorticolimbic Dopaminergic System
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