scholarly journals Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets

2012 ◽  
Vol 23 (9) ◽  
pp. 2136-2145 ◽  
Author(s):  
C. Yokoyama ◽  
A. Kawasaki ◽  
T. Hayashi ◽  
H. Onoe
Keyword(s):  
Positron Emission Tomography ◽  
Social Behavior ◽  
Serotonergic System ◽  
Emission Tomography ◽  
Common Marmosets ◽  
Positron Emission

scholarly journals Regulation of Noise-Induced Loss of Serotonin Transporters with Resveratrol in a Rat Model Using 4-[18F]-ADAM/Small-Animal Positron Emission Tomography

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1344 ◽  
Author(s):  
I-Hsun Li ◽  
Jui-Hu Shih ◽  
Yun-Tin Jhao ◽  
Hsin-Chien Chen ◽  
Chuang-Hsin Chiu ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Auditory Cortex ◽  
Auditory System ◽  
Noise Exposure ◽  
Afferent Fiber ◽  
Serotonergic System ◽  
Emission Tomography ◽  
Serotonin Transporters ◽  
Positron Emission ◽  
Brainstem Response

Serotonin (5-HT) plays a crucial role in modulating the afferent fiber discharge rate in the inferior colliculus, auditory cortex, and other nuclei of the ascending auditory system. Resveratrol, a natural polyphenol phytoalexin, can inhibit serotonin transporters (SERT) to increase synaptic 5-HT levels. In this study, we investigated the effects of resveratrol on noise-induced damage in the serotonergic system. Male Sprague-Dawley rats were anaesthetized and exposed to an 8-kHz tone at 116 dB for 3.5 h. Resveratrol (30 mg/kg, intraperitoneal injection [IP]) and citalopram (20 mg/kg, IP), a specific SERT inhibitor used as a positive control, were administered once a day for four consecutive days, with the first treatment occurring 2 days before noise exposure. Auditory brainstem response testing and positron emission tomography (PET) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM, a specific radioligand for SERT) were used to evaluate functionality of the auditory system and integrity of the serotonergic system, respectively, before and after noise exposure. Finally, immunohistochemistry was performed 1 day after the last PET scan. Our results indicate that noise-induced serotonergic fiber loss occurred in multiple brain regions including the midbrain, thalamus, hypothalamus, striatum, auditory cortex, and frontal cortex. This noise-induced damage to the serotonergic system was ameliorated in response to treatment with resveratrol and citalopram. However, noise exposure increased the hearing threshold in the rats regardless of drug treatment status. We conclude that resveratrol has protective effects against noise-induced loss of SERT.

Mapping of serotonin transporters by positron emission tomography with [11c]DASB in conscious common marmosets: Comparison with rhesus monkeys

Synapse ◽  
2010 ◽  
Vol 64 (8) ◽  
pp. 594-601 ◽  
Author(s):  
Chihiro Yokoyama ◽  
Hajime Yamanaka ◽  
Kayo Onoe ◽  
Akihiro Kawasaki ◽  
Hiroko Nagata ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Rhesus Monkeys ◽  
Emission Tomography ◽  
Serotonin Transporters ◽  
Common Marmosets ◽  
Positron Emission

scholarly journals A positron emission tomography study of the serotonergic system in relation to anxiety in depression

2017 ◽  
Vol 27 (10) ◽  
pp. 1011-1021 ◽  
Author(s):  
Zafer Iscan ◽  
Gopalkumar Rakesh ◽  
Samantha Rossano ◽  
Jie Yang ◽  
Mengru Zhang ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Serotonergic System ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Positron Emission

scholarly journals Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193770 ◽  
Author(s):  
Pontus Plavén-Sigray ◽  
Granville James Matheson ◽  
Petter Gustavsson ◽  
Per Stenkrona ◽  
Christer Halldin ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Social Behavior ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Replication Study ◽  
Emission Tomography ◽  
Positron Emission
Sign in / Sign up

Export Citation Format

Share Document