scholarly journals The Expression of Contextual Fear Conditioning Involves Activation of an NMDA Receptor-Nitric Oxide Pathway in the Medial Prefrontal Cortex

2007 ◽  
Vol 18 (9) ◽  
pp. 2027-2035 ◽  
Author(s):  
L. B. Moraes Resstel ◽  
F. M. de Aguiar Correa ◽  
F. S. Guimaraes
Keyword(s):  
Nitric Oxide ◽  
Prefrontal Cortex ◽  
Nmda Receptor ◽  
Fear Conditioning ◽  
Medial Prefrontal Cortex ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Nitric Oxide Pathway

scholarly journals Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Frances Xia ◽  
Blake A Richards ◽  
Matthew M Tran ◽  
Sheena A Josselyn ◽  
Kaori Takehara-Nishiuchi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Fear Conditioning ◽  
Medial Prefrontal Cortex ◽  
Memory Consolidation ◽  
Fear Memory ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Spiking Activity

Following learning, increased coupling between spindle oscillations in the medial prefrontal cortex (mPFC) and ripple oscillations in the hippocampus is thought to underlie memory consolidation. However, whether learning-induced increases in ripple-spindle coupling are necessary for successful memory consolidation has not been tested directly. In order to decouple ripple-spindle oscillations, here we chemogenetically inhibited parvalbumin-positive (PV+) interneurons, since their activity is important for regulating the timing of spiking activity during oscillations. We found that contextual fear conditioning increased ripple-spindle coupling in mice. However, inhibition of PV+ cells in either CA1 or mPFC eliminated this learning-induced increase in ripple-spindle coupling without affecting ripple or spindle incidence. Consistent with the hypothesized importance of ripple-spindle coupling in memory consolidation, post-training inhibition of PV+ cells disrupted contextual fear memory consolidation. These results indicate that successful memory consolidation requires coherent hippocampal-neocortical communication mediated by PV+ cells.

scholarly journals Differential involvement of the medial prefrontal cortex across variants of contextual fear conditioning

2017 ◽  
Vol 24 (8) ◽  
pp. 322-330 ◽  
Author(s):  
Nicholas A. Heroux ◽  
Patrese A. Robinson-Drummer ◽  
Hollie R. Sanders ◽  
Jeffrey B. Rosen ◽  
Mark E. Stanton
Keyword(s):  
Prefrontal Cortex ◽  
Fear Conditioning ◽  
Medial Prefrontal Cortex ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Differential Involvement

The expression of contextual fear conditioning involves activation of a NMDA receptor-nitric oxide-cGMP pathway in the dorsal hippocampus of rats

2014 ◽  
Vol 24 (10) ◽  
pp. 1676-1686 ◽  
Author(s):  
Denise R.S. Fabri ◽  
Sara C. Hott ◽  
Daniel G. Reis ◽  
Caroline Biojone ◽  
Fernando M.A. Corrêa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nmda Receptor ◽  
Fear Conditioning ◽  
Dorsal Hippocampus ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Cgmp Pathway

scholarly journals Cannabinoid CB1 receptors in the medial prefrontal cortex modulate the expression of contextual fear conditioning

2010 ◽  
Vol 13 (09) ◽  
pp. 1163-1173 ◽  
Author(s):  
Sabrina F. Lisboa ◽  
Daniel G. Reis ◽  
Andréia Lopes da Silva ◽  
Fernando M. A. Corrêa ◽  
Francisco S. Guimarães ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Fear Conditioning ◽  
Medial Prefrontal Cortex ◽  
Contextual Fear Conditioning ◽  
Cb1 Receptors ◽  
Contextual Fear
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