scholarly journals The Different Neural Correlates of Action and Functional Knowledge in Semantic Memory: An fMRI Study

2007 ◽  
Vol 18 (4) ◽  
pp. 740-751 ◽  
Author(s):  
N. Canessa ◽  
F. Borgo ◽  
S. F. Cappa ◽  
D. Perani ◽  
A. Falini ◽  
...  
2021 ◽  
Author(s):  
Meighen Roes ◽  
Abhijit Mahesh Chinchani ◽  
Todd Woodward

Patients with schizophrenia exhibit deficits in associative learning and semantic memory. The current functional magnetic resonance imaging (fMRI) study investigated the neural correlates of successful versus unsuccessful semantic associative encoding in schizophrenia compared to healthy controls. Publicly shared fMRI data from the UCLA Consortium for Neuropsychiatric Phenomics LA5C study were analyzed. Forty-four patients with schizophrenia and 78 healthy controls performed a paired-associates encoding task. Constrained principal component analysis for fMRI (fMRI-CPCA) revealed three distinct functional networks recruited during encoding: a responding (RESP) network, a linguistic processing/attention network (LANG/ATTN), and the default mode network (DMN). Relative to healthy controls, patients showed aberrant activity in all three networks; namely, hypo-activation in the LANG/ATTN network during successful encoding, lower peak activation and weaker post-activation suppression of the RESP network, and weaker suppression in the DMN during successful encoding. Independent of group effects, a pattern of stronger anticorrelating LANG/ATTN-DMN activity during successful encoding significantly predicted subsequent retrieval of paired associates. Together with previous observations of language network hypoactivation during controlled semantic associative memory processes, these results suggest that reduced activity in linguistic processing areas is a reliable biological marker associated with impaired semantic memory in schizophrenia.


2009 ◽  
Vol 171 (2) ◽  
pp. 94-105 ◽  
Author(s):  
Christoph Mensebach ◽  
Thomas Beblo ◽  
Martin Driessen ◽  
Katja Wingenfeld ◽  
Markus Mertens ◽  
...  

2006 ◽  
Author(s):  
Arthur Aron ◽  
Helen Fisher ◽  
Greg Strong ◽  
Deb Mashek ◽  
HaiFang Li ◽  
...  

2013 ◽  
Author(s):  
Antonello Pellicano ◽  
Houpand Horoufchin ◽  
Harshal Patel ◽  
Iring Koch ◽  
Ferdinand Binkofski

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
R Ilg ◽  
K Vogeley ◽  
T Goschke ◽  
A Bolte ◽  
NJ Shah ◽  
...  

Author(s):  
Gianluca Serafini ◽  
Maurizio Pompili ◽  
Andrea Romano ◽  
Denise Erbuto ◽  
Dorian A. Lamis ◽  
...  

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Mirko Lehmann ◽  
Claudia Neumann ◽  
Sven Wasserthal ◽  
Johannes Schultz ◽  
Achilles Delis ◽  
...  

Abstract Only little research has been conducted on the pharmacological underpinnings of metacognition. Here, we tested the modulatory effects of a single intravenous dose (100 ng/ml) of the N-methyl-D-aspartate-glutamate-receptor antagonist ketamine, a compound known to induce altered states of consciousness, on metacognition and its neural correlates. Fifty-three young, healthy adults completed two study phases of an episodic memory task involving both encoding and retrieval in a double-blind, placebo-controlled fMRI study. Trial-by-trial confidence ratings were collected during retrieval. Effects on the subjective state of consciousness were assessed using the 5D-ASC questionnaire. Confirming that the drug elicited a psychedelic state, there were effects of ketamine on all 5D-ASC scales. Acute ketamine administration during retrieval had deleterious effects on metacognitive sensitivity (meta-d′) and led to larger metacognitive bias, with retrieval performance (d′) and reaction times remaining unaffected. However, there was no ketamine effect on metacognitive efficiency (meta-d′/d′). Measures of the BOLD signal revealed that ketamine compared to placebo elicited higher activation of posterior cortical brain areas, including superior and inferior parietal lobe, calcarine gyrus, and lingual gyrus, albeit not specific to metacognitive confidence ratings. Ketamine administered during encoding did not significantly affect performance or brain activation. Overall, our findings suggest that ketamine impacts metacognition, leading to significantly larger metacognitive bias and deterioration of metacognitive sensitivity as well as unspecific activation increases in posterior hot zone areas of the neural correlates of consciousness.


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