scholarly journals Functional Maturation of Excitatory Synapses in Layer 3 Pyramidal Neurons during Postnatal Development of the Primate Prefrontal Cortex

2007 ◽  
Vol 18 (3) ◽  
pp. 626-637 ◽  
Author(s):  
G. Gonzalez-Burgos ◽  
S. Kroener ◽  
A. V. Zaitsev ◽  
N. V. Povysheva ◽  
L. S. Krimer ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Postnatal Development ◽  
Pyramidal Neurons ◽  
Excitatory Synapses ◽  
Functional Maturation

scholarly journals Plasticity in prefrontal cortex induced by coordinated nucleus reuniens and hippocampal synaptic transmission

2020 ◽  
Author(s):  
Paul J Banks ◽  
E Clea Warburton ◽  
Zafar I Bashir
Keyword(s):  
Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Ex Vivo ◽  
Excitatory Synapses ◽  
Short Term ◽  
Nucleus Reuniens ◽  
Short Term Plasticity ◽  
Physiological Properties ◽  
Theta Frequency ◽  
Afferent Inputs

AbstractThe nucleus reuniens of the thalamus (NRe) is reciprocally connected to a range of higher order cortices including hippocampus (HPC) and medial prefrontal cortex (mPFC). The physiological function of NRe is well predicted by requirement for interactions between mPFC and HPC, including associative recognition memory, spatial navigation and working memory. Although anatomical and electrophysiological evidence suggests NRe makes excitatory synapses in mPFC there is little data on the physiological properties of these projections, or whether NRe and HPC target overlapping cell populations and, if so, how they interact. We demonstrate in ex vivo mPFC slices that NRe and HPC afferent inputs converge onto more than two-thirds of layer 5 pyramidal neurons, show that NRe, but not HPC, undergoes marked short-term plasticity at theta, and that HPC, but not NRe, afferents are subject to neuromodulation by acetylcholine acting via muscarinic receptor M2. Finally, we demonstrate that pairing HPC followed by NRe (but not pairing NRe followed by HPC) at theta frequency induces associative, NMDA receptor dependent synaptic plasticity in both inputs to mPFC. These data provide vital physiological phenotypes of the synapses of this circuit and provide a novel mechanism for HPC-NRe-mPFC encoding.

scholarly journals Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex

2014 ◽  
Vol 25 (11) ◽  
pp. 4076-4093 ◽  
Author(s):  
Guillermo Gonzalez-Burgos ◽  
Takeaki Miyamae ◽  
Diego E. Pafundo ◽  
Hiroki Yoshino ◽  
Diana C. Rotaru ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Postnatal Development ◽  
Dorsolateral Prefrontal Cortex ◽  
Functional Maturation ◽  
Dorsolateral Prefrontal

scholarly journals Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tim Kroon ◽  
Eline van Hugte ◽  
Lola van Linge ◽  
Huibert D. Mansvelder ◽  
Rhiannon M. Meredith
Keyword(s):  
Prefrontal Cortex ◽  
Postnatal Development ◽  
Medial Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Early Postnatal Development

scholarly journals Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and Hippocampus

2021 ◽  
Author(s):  
Paul J Banks ◽  
E Clea Warburton ◽  
Zafar I Bashir
Keyword(s):  
Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Ex Vivo ◽  
Excitatory Synapses ◽  
Short Term ◽  
Nucleus Reuniens ◽  
Short Term Plasticity ◽  
Physiological Properties ◽  
Theta Frequency ◽  
Afferent Inputs

Abstract The nucleus reuniens and rhomboid nuclei of the thalamus (ReRh) are reciprocally connected to a range of higher order cortices including hippocampus (HPC) and medial prefrontal cortex (mPFC). The physiological function of ReRh is well predicted by requirement for interactions between mPFC and HPC, including associative recognition memory, spatial navigation and working memory. Although anatomical and electrophysiological evidence suggests ReRh makes excitatory synapses in mPFC there is little data on the physiological properties of these projections, or whether ReRh and HPC target overlapping cell populations and, if so, how they interact. We demonstrate in ex vivo mPFC slices that ReRh and HPC afferent inputs converge onto more than two-thirds of layer 5 pyramidal neurons, show that ReRh, but not HPC, undergoes marked short-term plasticity during theta frequency transmission, and that HPC, but not ReRh, afferents are subject to neuromodulation by acetylcholine acting via muscarinic receptor M2. Finally, we demonstrate that pairing HPC followed by ReRh (but not pairing ReRh followed by HPC) at theta frequency induces associative, NMDA receptor dependent synaptic plasticity in both inputs to mPFC. These data provide vital physiological phenotypes of the synapses of this circuit and provide a novel mechanism for HPC-ReRh-mPFC encoding.

Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset

2014 ◽  
Vol 220 (6) ◽  
pp. 3245-3258 ◽  
Author(s):  
Tetsuya Sasaki ◽  
Hirosato Aoi ◽  
Tomofumi Oga ◽  
Ichiro Fujita ◽  
Noritaka Ichinohe
Keyword(s):  
Prefrontal Cortex ◽  
Postnatal Development ◽  
Medial Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Dendritic Structure
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