scholarly journals Prefrontal Cortical Activation Associated with Working Memory in Adults and Preschool Children: An Event-related Optical Topography Study

2004 ◽  
Vol 14 (7) ◽  
pp. 703-712 ◽  
Author(s):  
S. Tsujimoto
Keyword(s):  
Working Memory ◽  
Preschool Children ◽  
Cortical Activation ◽  
Prefrontal Cortical ◽  
Optical Topography

MEDIAL PREFRONTAL CORTICAL ACTIVATION DURING WORKING MEMORY DIFFERENTIATES SCHIZOPHRENIA AND BIPOLAR PSYCHOTIC PATIENTS: A PILOT STUDY

2010 ◽  
Vol 117 (2-3) ◽  
pp. 355
Author(s):  
Snezana M. Milanovic ◽  
Heidi W. Thermenos ◽  
Ariel Brown ◽  
Jill M. Goldstein ◽  
Susan W. Gabrieli ◽  
...  
Keyword(s):  
Working Memory ◽  
Pilot Study ◽  
Cortical Activation ◽  
Prefrontal Cortical ◽  
Medial Prefrontal Cortical

621. Risk Profile Score (RPS) and Prefrontal Cortical Activation in Patients with Schizophrenia during Working Memory

2017 ◽  
Vol 81 (10) ◽  
pp. S251-S252 ◽  
Author(s):  
Jacob Morse ◽  
Michael Gregory ◽  
Jean-Paul Mikhael ◽  
Daniel Weinberger ◽  
Karen Berman ◽  
...  
Keyword(s):  
Working Memory ◽  
Risk Profile ◽  
Cortical Activation ◽  
Prefrontal Cortical ◽  
Profile Score

scholarly journals Medial prefrontal cortical activation during working memory differentiates schizophrenia and bipolar psychotic patients: A pilot FMRI study

2011 ◽  
Vol 129 (2-3) ◽  
pp. 208-210 ◽  
Author(s):  
Snezana M. Milanovic ◽  
Heidi W. Thermenos ◽  
Jill M. Goldstein ◽  
Ariel Brown ◽  
Susan Whitfield Gabrieli ◽  
...  
Keyword(s):  
Working Memory ◽  
Cortical Activation ◽  
Prefrontal Cortical ◽  
Fmri Study ◽  
Medial Prefrontal Cortical

Dopamine Increases the Gain of the Input-Output Response of Rat Prefrontal Pyramidal Neurons

2008 ◽  
Vol 99 (6) ◽  
pp. 2985-2997 ◽  
Author(s):  
Kay Thurley ◽  
Walter Senn ◽  
Hans-Rudolf Lüscher
Keyword(s):  
Working Memory ◽  
Neuronal Excitability ◽  
Pyramidal Neurons ◽  
D1 Receptors ◽  
Input Output ◽  
Prefrontal Cortical ◽  
Noisy Input ◽  
Relationship Of

Dopaminergic modulation of prefrontal cortical activity is known to affect cognitive functions like working memory. Little consensus on the role of dopamine modulation has been achieved, however, in part because quantities directly relating to the neuronal substrate of working memory are difficult to measure. Here we show that dopamine increases the gain of the frequency-current relationship of layer 5 pyramidal neurons in vitro in response to noisy input currents. The gain increase could be attributed to a reduction of the slow afterhyperpolarization by dopamine. Dopamine also increases neuronal excitability by shifting the input-output functions to lower inputs. The modulation of these response properties is mainly mediated by D1 receptors. Integrate-and-fire neurons were fitted to the experimentally recorded input-output functions and recurrently connected in a model network. The gain increase induced by dopamine application facilitated and stabilized persistent activity in this network. The results support the hypothesis that catecholamines increase the neuronal gain and suggest that dopamine improves working memory via gain modulation.

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