scholarly journals Genetic polymorphisms in DNA double-strand break repair genes XRCC5 , XRCC6 and susceptibility to hepatocellular carcinoma

2011 ◽  
Vol 32 (4) ◽  
pp. 530-536 ◽  
Author(s):  
Rui Li ◽  
Yuan Yang ◽  
Yu An ◽  
Yun Zhou ◽  
Yanhong Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Genetic Polymorphisms ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Break Repair ◽  
Repair Genes

scholarly journals Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-InducedγH2A.X Foci

2008 ◽  
Vol 2008 ◽  
pp. 1-8 ◽  
Author(s):  
Christina A. Markunas ◽  
David M. Umbach ◽  
Zongli Xu ◽  
Jack A. Taylor
Keyword(s):  
Cell Lines ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Screening Criteria ◽  
Phenotypic Differences ◽  
Dna Double Strand Break ◽  
Significant Difference ◽  
Break Repair ◽  
Repair Genes

Nonsynonymous SNPs (nsSNPs) in DNA repair genes may be important determinants of DNA damage and cancer risk. We applied a set of screening criteria to a large number of nsSNPs and selected a subset of SNPs that were likely candidates for phenotypic effects on DNA double-strand break repair (DSBR). In order to induce and follow DSBR, we exposed panels of cell lines to gamma irradiation and followed the formation and disappearance ofγH2A.X foci over time. All panels of cell lines showed significant increases in number, intensity, and area of foci at both the 1-hour and 3-hour time points. Twenty four hours following exposure, the number of foci returned to preexposure levels in all cell lines, whereas the size and intensity of foci remained significantly elevated. We saw no significant difference inγH2A.X foci between controls and any of the panels of cell lines representing the different nsSNPs.

scholarly journals Polymorphisms in DNA Double-Strand Break Repair Genes and Skin Cancer Risk

2004 ◽  
Vol 64 (9) ◽  
pp. 3009-3013 ◽  
Author(s):  
Jiali Han ◽  
Graham A. Colditz ◽  
Leona D. Samson ◽  
David J. Hunter
Keyword(s):  
Skin Cancer ◽  
Cancer Risk ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Skin Cancer Risk ◽  
Dna Double Strand Break ◽  
Break Repair ◽  
Repair Genes

Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses

2006 ◽  
Vol 119 (4) ◽  
pp. 376-388 ◽  
Author(s):  
Montserrat García-Closas ◽  
Kathleen M. Egan ◽  
Polly A. Newcomb ◽  
Louise A. Brinton ◽  
Linda Titus-Ernstoff ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Strand Break ◽  
Population Based ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Break Repair ◽  
Meta Analyses ◽  
Repair Genes
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