scholarly journals Chemopreventive effect of trans -resveratrol - a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis

2005 ◽  
Vol 27 (5) ◽  
pp. 1038-1046 ◽  
Author(s):  
Murugan Sengottuvelan ◽  
Periaswamy Viswanathan ◽  
Namasivayam Nalini
Keyword(s):  
Cell Proliferation ◽  
Colon Carcinogenesis ◽  
Aberrant Crypt Foci ◽  
Chemopreventive Effect

scholarly journals Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies

1998 ◽  
Vol 80 (S2) ◽  
pp. S219-S223 ◽  
Author(s):  
Bandaru S. Reddy
Keyword(s):  
Cell Proliferation ◽  
Bifidobacterium Longum ◽  
Colon Carcinogenesis ◽  
Aberrant Crypt Foci ◽  
Mucosal Cell ◽  
Laboratory Studies ◽  
Preneoplastic Lesions ◽  
Colon Tumour ◽  
Colonic Tumour ◽  
Mucosal Cell Proliferation

Oligofructose and inulin, selective fermentable chicory fructans, have been shown to stimulate the growth of bifidobacteria which are regarded as beneficial strains in the colon. Studies were designed to evaluate inulin (Raftiline) and oligofructose (Raftilose), for their potential inhibitory properties against aberrant crypt foci (ACF) formation in the colon of rats. ACF are putative preneoplastic lesions from which adenomas and carcinomas may develop. The results of this study demonstrate that dietary administration of oligofructose and inulin inhibits the formation of preneoplastic lesions in the colon suggesting the potential colon tumour inhibitory properties of chicory fructans. Since these prebiotics selectively stimulate the growth of bifidobacteria, tumour inhibitory activity of lyophilized cultures of Bifidobacterium longum (BL) against azoxymethane (AOM)-induced colon carcinogenesis in rats and modulating effect of these cultures on colonic tumour cell proliferation, ornithine decarboxylase (ODC) activity, and ras-p21 oncoprotein expression were investigated. Dietary administration of lyophilized cultures of BL strongly suppressed AOM-induced colon tumour development. Inhibition of colon carcinogenesis was associated with a decrease in colonic mucosal cell proliferation and colonic mucosal and tumour ODC and ras-p21 activities.

scholarly journals Djulis (Chenopodium Formosanum) Prevents Colon Carcinogenesis via Regulating Antioxidative and Apoptotic Pathways in Rats

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2168 ◽  
Author(s):  
Chih-Wei Lee ◽  
Hong-Jhang Chen ◽  
Gui-Ru Xie ◽  
Chun-Kuang Shih
Keyword(s):  
Colon Cancer ◽  
Colon Carcinogenesis ◽  
Aberrant Crypt Foci ◽  
Nuclear Antigen ◽  
Preneoplastic Lesions ◽  
Caspase 9 ◽  
Cereal Product ◽  
Chemopreventive Effect ◽  
Apoptotic Pathways ◽  
Proliferating Cell

Djulis is a cereal crop rich in polyphenols and dietary fiber that may have nutraceutical activity to prevent colon cancer. This study was designed to examine the preventive effect of djulis on colon carcinogenesis in rats treated with 1,2-dimethylhydrazine (DMH). Rats were fed different AIN-93G-based diets: groups N and DMH were fed AIN-93G diet and groups LD, MD, and HD were fed AIN-93G diet containing 5, 10, and 20% djulis, respectively. All rats except for group N were injected with DMH to induce colon carcinogenesis. After 10 weeks, rats were sacrificed and colon and liver tissues were collected for analysis. The results showed that djulis-treated rats had significantly lower numbers of colonic preneoplastic lesions, aberrant crypt foci (ACF), sialomucin-producing (SIM)-ACF, and mucin-depleted foci. Djulis treatment increased superoxide dismutase and catalase activities in colon and liver. Djulis also reduced p53, Bcl-2, and proliferating cell nuclear antigen expressions and increased Bax and caspase-9 expressions. Besides, phenolic compounds and flavonoids were found rich in djulis. These results demonstrate the chemopreventive effect of djulis on carcinogen-induced colon carcinogenesis via regulating antioxidative and apoptotic pathways in rats. Djulis may have the potential to be developed as a valuable cereal product for chemoprevention of colon cancer.

scholarly journals Non-Steroidal Anti-Inflammatory Drugs in Colorectal Cancer Chemoprevention

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 594
Author(s):  
Jadwiga Maniewska ◽  
Dagmara Jeżewska
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Clinical Trials ◽  
Cancer Chemoprevention ◽  
Tumor Cell Proliferation ◽  
Double Blind ◽  
New Approach ◽  
Randomized Controlled ◽  
Inflammatory Drugs ◽  
Chemopreventive Effect

Since colorectal cancer is one of the world’s most common cancers, studies on its prevention and early diagnosis are an emerging area of clinical oncology these days. For this study, a review of randomized controlled, double-blind clinical trials of selected NSAIDs (aspirin, sulindac and celecoxib) in chemoprevention of colorectal cancer was conducted. The main molecular anticancer activity of NSAIDs is thought to be a suppression of prostaglandin E2 synthesis via cyclooxygenase-2 inhibition, which causes a decrease in tumor cell proliferation, angiogenesis, and increases apoptosis. The lower incidence of colorectal cancer in the NSAID patients suggests the long-lasting chemopreventive effect of drugs studied. This new approach to therapy of colorectal cancer may transform the disease from a terminal to a chronic one that can be taken under control.

scholarly journals NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδContribute to Colon Carcinogenesis?

PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-11 ◽  
Author(s):  
Gerardo G. Mackenzie ◽  
Shaheen Rasheed ◽  
William Wertheim ◽  
Basil Rigas
Keyword(s):  
Cancer Biology ◽  
Antitumor Effect ◽  
Colon Carcinogenesis ◽  
Wild Type ◽  
Antineoplastic Effect ◽  
Intestinal Neoplasia ◽  
Chemopreventive Effect ◽  
The Relationship ◽  
Epithelial Cell Death

The chemopreventive NO-donating NSAIDs (NO-NSAIDs; NSAIDs with an NO-releasing moiety) modulate PPARδand offer the opportunity to revisit the controversial role of PPARδin carcinogenesis (several papers report that PPARδeither promotes or inhibits cancer). This review summarizes the pharmacology of NO-NSAIDs, PPARδcancer biology, and the relationship between the two. In particular, a study of the chemopreventive effect of two isomers of NO-aspirin on intestinal neoplasia inMinmice showed that, compared to wild-type controls, PPARδis overexpressed in the intestinal mucosa ofMinmice; PPARδresponds tom- andp-NO-ASA proportionally to their antitumor effect (p->m-). This effect is accompanied by the induction of epithelial cell death, which correlates with the antineoplastic effect of NO-aspirin; and NO-aspirin's effect on PPARδis specific (no changes in PPARαor PPARγ). Although these data support the notion that PPARδpromotes intestinal carcinogenesis and its inhibition could be therapeutically useful, more work is needed before a firm conclusion is reached.

Synbiotic supplementation attenuates the promoting effect of indole-3-carbinol on colon tumorigenesis

2021 ◽  
pp. 1-10
Author(s):  
N.A. de Moura ◽  
B.F.R. Caetano ◽  
L.T. Bidinotto ◽  
M.A.M. Rodrigues ◽  
L.F. Barbisan
Keyword(s):  
Cell Proliferation ◽  
Colon Carcinogenesis ◽  
Basal Diet ◽  
Tumour Volume ◽  
Control Group ◽  
Promoting Effect ◽  
Bifidobacterium Lactis ◽  
Colon Tumorigenesis ◽  
Synbiotic Supplementation ◽  
Well Differentiated

Indole-3 carbinol (I3C) has shown dual effects on the promotion and progression stages of colon carcinogenesis while synbiotics (Syn) have exerted anti-carcinogenic activities in most rodent studies. This study aimed to investigate the effects of I3C given alone or together with a Syn intervention on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis. All animals were given four subcutaneous DMH injections (4×40 mg/kg bodyweight, twice a week for two weeks) and then received either basal diet (G1), basal diet containing I3C (1g/kg chow) (G2) or basal diet containing I3C+Syn (I3C + inulin 50g/kg chow + Bifidobacterium lactis BB-12®), 2.5×1010 cfu/g of basal diet), (G3) for 21 weeks. Dietary I3C (G2) significantly increased tumour volume and cell proliferation when compared to the DMH control group (G1). Syn intervention (G3) significantly reduced tumour volume and cell proliferation when compared to I3C (G2). The colon tumours found were classified into well-differentiated tubular adenomas or adenocarcinomas. Dietary I3C or I3C+Syn did not significantly affect the incidence and the multiplicity of tumours in comparison with the DMH control group. Furthermore, Syn intervention (G3) increased Gstm1 and reduced Mapk9 gene expression in colonic tumours. The findings of the present study show that the dietary I3C shows a weak promoting activity, while the combination with Syn ameliorates I3C effects.

Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis

2002 ◽  
Vol 26 (6) ◽  
pp. 419-425 ◽  
Author(s):  
Chinthalapally V Rao ◽  
Harold L Newmark ◽  
Bandaru S Reddy
Keyword(s):  
Colon Carcinogenesis ◽  
Chemopreventive Effect
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