Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis

2004 ◽  
Vol 26 (3) ◽  
pp. 525-530 ◽  
Author(s):  
J. Brabender
Keyword(s):  
Lung Cancer ◽  
Retinoic Acid ◽  
Small Cell Lung Cancer ◽  
Expression Analysis ◽  
Tumor Development ◽  
Small Cell ◽  
Retinoic Acid Receptors ◽  
Small Cell Lung ◽  
Retinoid X Receptors ◽  
X Receptors

scholarly journals Alterations in Retinoic Acid Receptors in Non-Small Cell Lung Cancer and Their Clinical Implications

2015 ◽  
Vol 06 (08) ◽  
pp. 648-664 ◽  
Author(s):  
Saé Muñiz-Hernández ◽  
Norma Hernández-Pedro ◽  
Omar E. Macedo-Pérez ◽  
Oscar Arrieta
Keyword(s):  
Lung Cancer ◽  
Retinoic Acid ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Retinoic Acid Receptors ◽  
Clinical Implications ◽  
Small Cell Lung

scholarly journals Retinoic Acid Receptor-β Expression in Stage I Non-Small Cell Lung Cancer and Adjacent Normal Appearing Bronchial Epithelium

2004 ◽  
Vol 45 (3) ◽  
pp. 435 ◽  
Author(s):  
Yoon Soo Chang ◽  
Jae Ho Chung ◽  
Dong Hwan Shin ◽  
Kyung Young Chung ◽  
Young Sam Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Retinoic Acid ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Retinoic Acid Receptor ◽  
Bronchial Epithelium ◽  
Small Cell ◽  
Stage I ◽  
Small Cell Lung ◽  
Acid Receptor

scholarly journals Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer

2018 ◽  
Vol 31 (4) ◽  
Author(s):  
Farbod Esfandi ◽  
Kholghi Oskooei Vahid ◽  
Taheri Fatemeh ◽  
Arda Kiani ◽  
Mohammad Taheri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Expression Analysis ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals FGFR1 Is Critical for RBL2 Loss–Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer

2020 ◽  
Vol 80 (22) ◽  
pp. 5051-5062
Author(s):  
Kee-Beom Kim ◽  
Youngchul Kim ◽  
Christopher J. Rivard ◽  
Dong-Wook Kim ◽  
Kwon-Sik Park
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Development ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer

Genomics Data ◽  
2015 ◽  
Vol 6 ◽  
pp. 145-148 ◽  
Author(s):  
Erin A. Marshall ◽  
Kevin W. Ng ◽  
Christine Anderson ◽  
Roland Hubaux ◽  
Kelsie L. Thu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Expression Analysis ◽  
Cell Lung Cancer ◽  
Gene Expression Analysis ◽  
Small Cell ◽  
Small Cell Lung

Co-occurring genetic alterations and primary EGFR T790M mutations detected by next-generation sequencing in pre-TKI treated patients with non-small cell lung cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e13128-e13128
Author(s):  
Yuan Tang ◽  
Bing Wei ◽  
Yang Yu ◽  
Yun Gao ◽  
Nanying Che ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Development ◽  
Point Mutations ◽  
Genetic Alterations ◽  
Small Cell ◽  
Small Cell Lung ◽  
Resected Nsclc ◽  
Egfr T790m

e13128 Background: With the development of targeted drugs, there are more therapeutic options for patients with non-small cell lung cancer (NSCLC) harboring corresponding genetic alterations. However, cancers are frequently caused by alterations on multiple genes, which collaborate to promote tumor development. Methods: A total of 1353 NSCLC patients from five different clinical institutions were enrolled in this study. Concurrent DNA and RNA NGS analysis was performed using the Ion Ampliseq Colon and Lung Cancer gene panel v2 and the AmpliSeq RNA Lung Cancer Research Fusion Panel using FFPE samples from surgically resected NSCLC tumors. Results: Of the 1293 mutations that were detected, 2338 variants were identified in 24 genes, while 27 of the tumor samples were identified to have co-occurring DNA mutations (including insertions, deletions and point mutations) and RNA fusion mutations. Analysis of the 975 patients with EGFR-gene mutations revealed that the incidence of dual EGFR L858R/T790M mutations were higher compared to EGFR 19del/T790M, and the MAF of T790M was lower compared to 19del in dual EGFR 19del/T790M patients. Conclusions: Even with the non-random cohort of patients in this study, the genetic alterations detected in this study had a certain degree of representation of NSCLC (especially lung adenocarcinoma) in the Chinese population. The differences in the MAF of EGFR T790M may determine different responses to TKI therapy in patients harboring dual mutations.

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