scholarly journals Can we use regional grey matter atrophy sequence to stage neurodegeneration in multiple sclerosis?

Brain ◽  
2018 ◽  
Vol 141 (6) ◽  
pp. 1580-1583 ◽  
Author(s):  
Bruno Stankoff ◽  
Céline Louapre
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Grey Matter Atrophy

Low CSF β-amyloid levels predict early regional grey matter atrophy in multiple sclerosis

2020 ◽  
Vol 39 ◽  
pp. 101899 ◽  
Author(s):  
Anna M. Pietroboni ◽  
Annalisa Colombi ◽  
Tiziana Carandini ◽  
Valeria E. Contarino ◽  
Laura Ghezzi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Β Amyloid ◽  
Grey Matter Atrophy

scholarly journals Blunted neural and psychological stress processing predicts future grey matter atrophy in multiple sclerosis

2020 ◽  
Vol 13 ◽  
pp. 100244
Author(s):  
Lil Meyer-Arndt ◽  
Stefan Hetzer ◽  
Susanna Asseyer ◽  
Judith Bellmann-Strobl ◽  
Michael Scheel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Psychological Stress ◽  
Grey Matter ◽  
Stress Processing ◽  
Grey Matter Atrophy

scholarly journals Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis

2019 ◽  
Vol 74 (10) ◽  
pp. 816.e19-816.e28 ◽  
Author(s):  
F.L. Chiang ◽  
Q. Wang ◽  
F.F. Yu ◽  
R.S. Romero ◽  
S.Y. Huang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Meta Analysis ◽  
Grey Matter Atrophy

scholarly journals Temporal and spatial evolution of grey matter atrophy in primary progressive multiple sclerosis

NeuroImage ◽  
2014 ◽  
Vol 86 ◽  
pp. 257-264 ◽  
Author(s):  
Arman Eshaghi ◽  
Benedetta Bodini ◽  
Gerard R. Ridgway ◽  
Daniel García-Lorenzo ◽  
Daniel J. Tozer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Progressive Multiple Sclerosis ◽  
Primary Progressive Multiple Sclerosis ◽  
Spatial Evolution ◽  
Primary Progressive ◽  
Temporal And Spatial Evolution ◽  
Temporal And Spatial ◽  
Grey Matter Atrophy

Exploration of the relationships between regional grey matter atrophy and cognition in multiple sclerosis

2012 ◽  
Vol 8 (3) ◽  
pp. 378-386 ◽  
Author(s):  
Ugo Nocentini ◽  
Marco Bozzali ◽  
Barbara Spanò ◽  
Mara Cercignani ◽  
Laura Serra ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Grey Matter Atrophy

scholarly journals Progression of regional grey matter atrophy in multiple sclerosis

2017 ◽  
Author(s):  
Arman Eshaghi ◽  
Razvan V. Marinescu ◽  
Alexandra L. Young ◽  
Nicholas C. Firth ◽  
Ferran Prados ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Disease Duration ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Data Driven ◽  
Healthy Controls ◽  
Primary Progressive ◽  
Grey Matter Atrophy ◽  
Over Time

SummaryGrey matter atrophy is present from the earliest clinical stages of multiple sclerosis (MS), but the temporal ordering is poorly understood. We aimed to determine the sequence in which grey matter regions become atrophic in MS, and its association with disability accumulation.In this longitudinal study, we included 1,417 subjects: 253 with clinically-isolated syndrome (CIS), 708 relapsing-remitting MS (RRMS), 128 secondary-progressive MS (SPMS), 125 primary-progressive MS (PPMS), and 203 healthy controls from 7 European centres. Subjects underwent repeated MRI scanning (total number of scans 3,604); the mean follow-up for patients was 2.41yrs (SD±1.97). Disability was scored using the Expanded Disability Status Scale (EDSS). We calculated the volume of brain grey matter regions and brainstem using an unbiased within-subject template. We used an established data-driven event-based model (EBM) to determine the sequence of occurrence of atrophy and its uncertainty. We assigned each subject to a specific EBM stage, based on the number of their atrophic regions. We used nested linear mixed-effects regression models to explore the associations between the rate of increase in the EBM stages over time, disease duration and annual rate of EDSS gain.The first regions to become atrophic in CIS and relapse-onset MS patients (RRMS and SPMS) were the posterior cingulate cortex and precuneus, followed by the middle cingulate cortex, brainstem and thalamus. The sequence of atrophy in PPMS showed a similar involvement of the thalamus, cuneus, precuneus, and pallidum, followed by the brainstem and posterior cingulate cortex. The cerebellum, caudate and putamen showed early atrophy in relapse-onset MS and late atrophy in PPMS. Patients with SPMS showed the highest EBM stages (highest number of atrophic regions, all p<0.001) at study entry. Rates of increase in EBM stages were significantly different from healthy controls in all MS phenotypes, except for CIS. The increase in the number of atrophic regions (EBM stage) was associated with disease duration in all patients. EBM stage was associated with disability accumulation in RRMS independent of disease duration (p<0.0001).This data-driven staging of atrophy progression in a large MS sample demonstrates that grey matter atrophy spreads to involve more regions over time. The sequence in which regions become atrophic is reasonably consistent across MS phenotypes. The spread of atrophy was associated with disease duration, and disability accumulation in RRMS.AbbreviationsMSmultiple sclerosisGMgrey matterFLAIRFluid Attenuated Inversion RecoveryPPMSprimary progressive multiple sclerosis; primary-progressive MS

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