scholarly journals Reply: Towards personalized therapy for multiple sclerosis: limitations of observational data

Brain ◽  
2018 ◽  
Vol 141 (5) ◽  
pp. e39-e39
Author(s):  
Tomas Kalincik
Keyword(s):  
Multiple Sclerosis ◽  
Observational Data ◽  
Personalized Therapy

scholarly journals Towards personalized therapy for multiple sclerosis: limitations of observational data

Brain ◽  
2018 ◽  
Vol 141 (5) ◽  
pp. e38-e38 ◽  
Author(s):  
Ewout W Steyerberg ◽  
Brian Claggett
Keyword(s):  
Multiple Sclerosis ◽  
Observational Data ◽  
Personalized Therapy

Pharmacogenomics of multiple sclerosis: in search for a personalized therapy

2008 ◽  
Vol 9 (17) ◽  
pp. 3053-3067 ◽  
Author(s):  
Iván Martinez-Forero ◽  
Antonio Pelaez ◽  
Pablo Villoslada
Keyword(s):  
Multiple Sclerosis ◽  
Personalized Therapy

scholarly journals Towards personalized therapy for multiple sclerosis: prediction of individual treatment response

Brain ◽  
2017 ◽  
Vol 140 (9) ◽  
pp. 2426-2443 ◽  
Author(s):  
Tomas Kalincik ◽  
Ali Manouchehrinia ◽  
Lukas Sobisek ◽  
Vilija Jokubaitis ◽  
Tim Spelman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Treatment Response ◽  
Personalized Therapy ◽  
Individual Treatment

Reporting treatment outcomes in observational data: A fine balance

2016 ◽  
Vol 23 (1) ◽  
pp. 21-22 ◽  
Author(s):  
Tomas Kalincik ◽  
Maria Pia Sormani
Keyword(s):  
Multiple Sclerosis ◽  
Cost Effectiveness ◽  
High Risk ◽  
Treatment Outcomes ◽  
Observational Data ◽  
Risk Of Bias ◽  
Statistical Methodology ◽  
Disease Modifying Therapies ◽  
Disease Modifying

Analyses of observational data have been gaining momentum in the evaluation of ever increasing spectrum of disease modifying therapies for multiple sclerosis. While high cost-effectiveness and generalisability represent their main advantages, these studies are also burdened with high risk of bias that may lead to erroneous conclusions. In this viewpoint, we highlight the key role of rigorous and transparent statistical methodology in the studies of observational data and encourage its thorough editorial scrutiny.

Genetic Markers for Personalized Therapy of Polygenic Diseases: Pharmacogenetics of Multiple Sclerosis

2019 ◽  
Vol 53 (4) ◽  
pp. 513-534
Author(s):  
E. Yu. Tsareva ◽  
O. O. Favorova ◽  
A. N. Boyko ◽  
O. G. Kulakova
Keyword(s):  
Multiple Sclerosis ◽  
Genetic Markers ◽  
Personalized Therapy ◽  
Polygenic Diseases
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