scholarly journals LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model

Brain ◽  
2016 ◽  
Vol 139 (10) ◽  
pp. 2722-2739 ◽  
Author(s):  
Yong-Hee Rhee ◽  
Tae-Ho Kim ◽  
A.-Young Jo ◽  
Mi-Yoon Chang ◽  
Chang-Hwan Park ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Neural Stem Cells ◽  
Therapeutic Potential ◽  
Disease Model

Directed Differentiation into Neural Lineages and Therapeutic Potential of Porcine Embryonic Stem Cells in Rat Parkinson's Disease Model

2010 ◽  
Vol 12 (4) ◽  
pp. 447-461 ◽  
Author(s):  
Jenn-Rong Yang ◽  
Chia-Hsin Liao ◽  
Cheng-Yoong Pang ◽  
Lynn Ling-Huei Huang ◽  
Yu-Ting Lin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Embryonic Stem Cells ◽  
Therapeutic Potential ◽  
Disease Model ◽  
Embryonic Stem ◽  
Directed Differentiation

scholarly journals Brain Transplantation of Neural Stem Cells Cotransduced with Tyrosine Hydroxylase and GTP Cyclohydrolase 1 in Parkinsonian Rats

2005 ◽  
Vol 14 (4) ◽  
pp. 193-202 ◽  
Author(s):  
M. Y. Ryu ◽  
M. A. Lee ◽  
Y. H. Ahn ◽  
K. S. Kim ◽  
S. H. Yoon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Tyrosine Hydroxylase ◽  
Neural Stem Cells ◽  
Neural Development ◽  
Therapeutic Potential ◽  
Genetically Modified ◽  
Rt Pcr ◽  
Gtp Cyclohydrolase

Neural stem cells (NSCs) of the central nervous system (CNS) recently have attracted a great deal of interest not only because of their importance in basic research on neural development, but also in terms of their therapeutic potential in neurological diseases, such as Parkinson's disease (PD). To examine if genetically modified NSCs are a suitable source for the cell and gene therapy of PD, an immortalized mouse NSC line, C17.2, was transduced with tyrosine hydroxylase (TH) gene and with GTP cyclohydrolase 1 (GTPCH1) gene, which are important enzymes in dopamine biosynthesis. The expression of TH in transduced C17.2-THGC cells was confirmed by RT-PCR, Western blot analysis, and immunocytochemistry, and expression of GTPCH1 by RT-PCR. The level of L-DOPA released by C17.2-THGC cells, as determined by HPLC assay, was 3793 pmol/106 cells, which is 760-fold higher than that produced by C17.2-TH cells, indicating that GTPCH1 expression is important for L-DOPA production by transduced C17.2 cells. Following the implantation of C17.2-THGcC NSCs into the striata of parkinsonian rats, a marked improvement in amphetamine-induced turning behavior was observed in parkinsonian rats grafted with C17.2-THGC cells but not in the control rats grafted with C17.2 cells. These results indicate that genetically modified NSCs grafted into the brain of the parkinsonian rats are capable of survival, migration, and neuronal differentiation. Collectively, these results suggest that NSCs have great potential as a source of cells for cell therapy and an effective vehicle for therapeutic gene transfer in Parkinson's disease.

scholarly journals Therapeutic Potential of Induced Neural Stem Cells for Parkinson’s Disease

2017 ◽  
Vol 18 (1) ◽  
pp. 224 ◽  
Author(s):  
Dong-Hee Choi ◽  
Ji-Hye Kim ◽  
Sung Kim ◽  
Kyuree Kang ◽  
Dong Han ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Neural Stem Cells ◽  
Therapeutic Potential ◽  
Induced Neural Stem Cells

scholarly journals Dopaminergic precursors differentiated from human blood-derived induced neural stem cells improve symptoms of a mouse Parkinson's disease model

Theranostics ◽  
2018 ◽  
Vol 8 (17) ◽  
pp. 4679-4694 ◽  
Author(s):  
Yanpeng Yuan ◽  
Xihe Tang ◽  
Yun-Fei Bai ◽  
Shuyan Wang ◽  
Jing An ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Neural Stem Cells ◽  
Human Blood ◽  
Disease Model ◽  
Induced Neural Stem Cells

The isolation of neural stem cells from the olfactory bulb of Parkinson's disease model

2007 ◽  
Vol 57 (3) ◽  
pp. 393-398 ◽  
Author(s):  
Hideki Hayakawa ◽  
Hiromi Hayashita-Kinoh ◽  
Tomoko Nihira ◽  
Tatsunori Seki ◽  
Yoshikuni Mizuno ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Olfactory Bulb ◽  
Neural Stem Cells ◽  
Disease Model

scholarly journals Neural stem cells restore cognitive function in Parkinsonian macaques

2021 ◽  
Author(s):  
Julien Vezoli ◽  
Florence Wianny ◽  
Kwamivi Dzahini ◽  
Karim Fifel ◽  
Charles Wilson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Neural Stem Cells ◽  
Functional Recovery ◽  
Therapeutic Potential ◽  
Motor Symptoms ◽  
The Impact ◽  
Non Motor Symptoms

Abstract Cognitive deficits as well as disorders of sleep and biological rhythms constitute non-motor symptoms that significantly impact quality of life in Parkinson’s disease patients. Few studies have evaluated the impact of cell replacement therapy on such non-motor symptoms. Here we used a multidisciplinary approach to assess the therapeutic potential of bilateral grafts of neural stem cells in a macaque model of Parkinson’s disease on both motor and non-motor markers of functional recovery. Grafts led to varying degrees of functional recovery while sham experiments did not. We show unprecedented recovery from cognitive symptoms in addition to a clear clinical motor recuperation. Motor and cognitive recovery but not circadian rhythm recovery correlated with the degree of graft integration into the host environment and with in-vivo levels of striatal dopaminergic transporters and function. This study provides empirical evidence that neural stem cells transplantation efficiently restore function at multiple levels in Parkinsonian non-human primates. We demonstrate the promising potential of multiple-sites neural stem cells grafts for Parkinson’s disease but furthermore underline the crucial importance of such multidisciplinary approaches for an effective clinical translation.

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