scholarly journals Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson’s disease: a pharmacogenetic study

Brain ◽  
2016 ◽  
Vol 139 (7) ◽  
pp. 2050-2062 ◽  
Author(s):  
Mario Masellis ◽  
Shannon Collinson ◽  
Natalie Freeman ◽  
Maria Tampakeras ◽  
Joseph Levy ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine D2 Receptor ◽  
Receptor Gene ◽  
D2 Receptor ◽  
Gene Variants ◽  
Pharmacogenetic Study ◽  
Dopamine D2 ◽  
Early Parkinson’S Disease

The dopamine D2 receptor gene is a susceptibility locus for Parkinson's disease

2000 ◽  
Vol 15 (1) ◽  
pp. 120-126 ◽  
Author(s):  
Rosario L. Oliveri ◽  
Grazia Annesi ◽  
Mario Zappia ◽  
Donatella Civitelli ◽  
Elvira V. De Marco ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine D2 Receptor ◽  
Receptor Gene ◽  
D2 Receptor ◽  
Susceptibility Locus ◽  
Dopamine D2

scholarly journals Revealing Adenosine A2A-Dopamine D2 Receptor Heteromers in Parkinson’s Disease Post-Mortem Brain through a New AlphaScreen-Based Assay

2019 ◽  
Vol 20 (14) ◽  
pp. 3600 ◽  
Author(s):  
Víctor Fernández-Dueñas ◽  
Maricel Gómez-Soler ◽  
Marta Valle-León ◽  
Masahiko Watanabe ◽  
Isidre Ferrer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dynamic Range ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Post Mortem ◽  
Dopamine D2 ◽  
Post Mortem Brain ◽  
Receptor Heteromers ◽  
Adenosine A2a

Background: Several biophysical techniques have been successfully implemented to detect G protein-coupled receptors (GPCRs) heteromerization. Although these approaches have made it possible to ascertain the presence of GPCR heteromers in animal models of disease, no success has been accomplished in pathological human post-mortem brains. The AlphaScreen technology has been consistently used to quantify small analyte accumulation or depletion, bimolecular interactions, and post-translational modifications. The high signal-to-background, dynamic range and sensitivity exhibited by this technology support that it may be suitable to detect GPCR heteromers even under non-optimal conditions. Methods: Here, we describe the development of a new AlphaScreen assay to detect GPCR oligomers in human post-mortem brain. Results: Adenosine A2A-dopamine D2 receptor (A2AR/D2R) heteromer formation was monitored in caudate from healthy and Parkinson’s disease (PD) subjects. The approach was first validated using striatal membranes from wild type and A2AR deficient mice. Secondly, we took advantage of the 6-hydroxydopamine hemiparkinsonian rat model to validate previous results. In addition, finally, A2AR/D2R heteromer formation was assessed in caudate membranes from human post-mortem brains. Importantly, our preliminary results revealed an increase in A2AR/D2R heteromer formation in PD brains. Conclusions: The new AlphaScreen assay allowed assessing GPCR heteromers in human post-mortem brains with high sensitivity.

Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease

2003 ◽  
Vol 18 (5) ◽  
pp. 593-595 ◽  
Author(s):  
Eng-King Tan ◽  
Yanni Tan ◽  
Anthea Chai ◽  
Christopher Tan ◽  
Hui Shen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2
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