scholarly journals Freezing of gait in Parkinson’s disease is associated with functional decoupling between the cognitive control network and the basal ganglia

Brain ◽  
2013 ◽  
Vol 136 (12) ◽  
pp. 3671-3681 ◽  
Author(s):  
James M. Shine ◽  
Elie Matar ◽  
Philip B. Ward ◽  
Michael J. Frank ◽  
Ahmed A. Moustafa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Cognitive Control ◽  
Freezing Of Gait ◽  
Control Network ◽  
Cognitive Control Network

scholarly journals The Effect of Parkinson's Disease on the Dynamics of On-line and Proactive Cognitive Control during Action Selection

2010 ◽  
Vol 22 (9) ◽  
pp. 2058-2073 ◽  
Author(s):  
Scott A. Wylie ◽  
K. Richard Ridderinkhof ◽  
Theodore R. Bashore ◽  
Wery P. M. van den Wildenberg
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Cognitive Control ◽  
Incorrect Response ◽  
Motor Symptom ◽  
Control Mechanisms ◽  
Proactive Control ◽  
On Line ◽  
Response Activation

Processing irrelevant visual information sometimes activates incorrect response impulses. The engagement of cognitive control mechanisms to suppress these impulses and make proactive adjustments to reduce the future impact of incorrect impulses may rely on the integrity of frontal–basal ganglia circuitry. Using a Simon task, we investigated the effects of basal ganglia dysfunction produced by Parkinson's disease (PD) on both on-line (within-trial) and proactive (between-trial) control efforts to reduce interference produced by the activation of an incorrect response. As a novel feature, we applied distributional analyses, guided by the activation–suppression model, to differentiate the strength of incorrect response activation and the proficiency of suppression engaged to counter this activation. For situations requiring on-line control, PD (n = 52) and healthy control (n = 30) groups showed similar mean interference effects (i.e., Simon effects) on reaction time (RT) and accuracy. Distributional analyses showed that although the strength of incorrect response impulses was similar between the groups PD patients were less proficient at suppressing these impulses. Both groups demonstrated equivalent and effective proactive control of response interference on mean RT and accuracy rates. However, PD patients were less effective at reducing the strength of incorrect response activation proactively. Among PD patients, motor symptom severity was associated with difficulties in on-line, but not in proactive, control of response impulses. These results suggest that basal ganglia dysfunction produced by PD has selective effects on cognitive control mechanisms engaged to resolve response conflict, with primary deficits in the on-line suppression of incorrect responses occurring in the context of a relatively spared ability to adjust control proactively to minimize future conflict.

Impaired cognitive control in Parkinson’s disease patients with freezing of gait in response to cognitive load

2014 ◽  
Vol 122 (5) ◽  
pp. 653-660 ◽  
Author(s):  
Courtney C. Walton ◽  
James M. Shine ◽  
Loren Mowszowski ◽  
Moran Gilat ◽  
Julie M. Hall ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Control ◽  
Cognitive Load ◽  
Freezing Of Gait

scholarly journals The On-Freezing Phenomenon: Cognitive and Behavioral Aspects

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Rita Moretti ◽  
Paola Torre ◽  
Rodolfo M. Antonello ◽  
Francesca Esposito ◽  
Giuseppe Bellini
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Freezing Of Gait ◽  
Warning Sign ◽  
Abstract Reasoning ◽  
Set Shifting ◽  
Dopaminergic Therapy ◽  
Behavioral Aspects ◽  
Wearing Off

Freezing of gait is a warning sign of Parkinson's disease. One could distinguish off-freezing, which is associated with dopaminergic therapy and to its titration, and it is clinically related to wearing-off phenomenon. Differently, the on-freezing phenomenon seems to be related to a neural disruption of the frontal-parietal-basal ganglia-pontine projections; clinically, it does not respond to therapy modifications or to different drug titration. In a group of patients with on-freezing, we have detected an alteration of focusing attention, an impairment of set-shifting, in addition to poor abstract reasoning and a reduction of planning. These aspects have been even more evident, when compared with the results obtained by a group of PD patients, without freezing.

Antisaccade errors reveal cognitive control deficits in Parkinson’s disease with freezing of gait

2015 ◽  
Vol 262 (12) ◽  
pp. 2745-2754 ◽  
Author(s):  
Courtney C. Walton ◽  
Claire O’Callaghan ◽  
Julie M. Hall ◽  
Moran Gilat ◽  
Loren Mowszowski ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Control ◽  
Freezing Of Gait

Side of basal ganglia degeneration influences freezing of gait in Parkinson’s disease.

2015 ◽  
Vol 129 (2) ◽  
pp. 214-218 ◽  
Author(s):  
Frederico Pieruccini-Faria ◽  
Kaylena A. Ehgoetz Martens ◽  
Carolina R. A. Silveira ◽  
Jeffery A. Jones ◽  
Quincy J. Almeida
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Freezing Of Gait ◽  
Basal Ganglia Degeneration

A Basal Ganglia Model of Freezing of Gait in Parkinson’s Disease

2018 ◽  
pp. 113-129
Author(s):  
Vignesh Muralidharan ◽  
Pragathi Priyadharsini Balasubramani ◽  
V. Srinivasa Chakravarthy ◽  
Ahmed A. Moustafa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Freezing Of Gait

SPECT-Befunde bei Hemiparkinson-Syndrom mit 99mTc-HMPAO

1989 ◽  
Vol 28 (03) ◽  
pp. 92-94 ◽  
Author(s):  
C. Neumann ◽  
H. Baas ◽  
R. Hefner ◽  
G. Hör
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Neuronal Activity ◽  
Tracer Uptake ◽  
The Body ◽  
99Mtc Hmpao ◽  
Do So

The symptoms of Parkinson’s disease often begin on one side of the body and continue to do so as the disease progresses. First SPECT results in 4 patients with hemiparkinsonism using 99mTc-HMPAO as perfusion marker are reported. Three patients exhibited reduced tracer uptake in the contralateral basal ganglia One patient who was under therapy for 1 year, showed a different perfusion pattern with reduced uptake in both basal ganglia. These results might indicate reduced perfusion secondary to reduced striatal neuronal activity.

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