scholarly journals Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis

Brain ◽  
2009 ◽  
Vol 132 (5) ◽  
pp. 1259-1267 ◽  
Author(s):  
J. Rodgers ◽  
T. W. Stone ◽  
M. P. Barrett ◽  
B. Bradley ◽  
P. G. E. Kennedy
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Human African Trypanosomiasis ◽  
Kynurenine Pathway ◽  
African Trypanosomiasis ◽  
Central Nervous System Inflammation ◽  
Pathway Inhibition

scholarly journals The relationship of endotoxaemia to peripheral and central nervous system inflammatory responses in Human African Trypanosomiasis

Parasitology ◽  
2016 ◽  
Vol 144 (4) ◽  
pp. 557-562 ◽  
Author(s):  
LORNA MACLEAN ◽  
ELTAYB A. ABOUBAKER ◽  
PETER G. E. KENNEDY ◽  
JEREMY M. STERNBERG
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Human African Trypanosomiasis ◽  
Inflammatory Responses ◽  
African Trypanosomiasis ◽  
Trypanosoma Brucei Rhodesiense ◽  
Neurological Sequelae ◽  
Gut Leakage ◽  
Relationship Of ◽  
The Relationship

SUMMARYEndotoxaemia has been described in cases of Human African trypanosomiasis (HAT), but it is unclear if this phenomenon influences inflammatory pathology either in the periphery or central nervous system (CNS). We studied endotoxin concentrations in the plasma and cerebrospinal fluid (CSF) of Trypanosoma brucei rhodesiense patients using the chromogenic Limulus Amoebocyte lysate assay. The relationship of endotoxin concentration to the presentation of gross signs of inflammation and the inflammatory/counter-inflammatory cytokine profile of the relevant compartments were analysed. We demonstrate that HAT patients exhibit parasitaemia-independent plasma endotoxaemia, and that this is associated with splenomegaly and lymphadenopathy. Endotoxin concentrations normalize rapidly after treatment. There was no evidence of endotoxin release in the CNS. A rapid normalization of endotoxin levels after treatment and lack of association with parasitaemia suggest that gut leakage is the main source of endotoxin in the circulation. Low CSF endotoxin concentrations and a lack of any association with neuroinflammatory markers or neurological sequelae suggest that endotoxin does not play a role in the pathogenesis of the disease in the CNS.

scholarly journals A cell-based drug delivery platform for treating central nervous system inflammation

2021 ◽  
Author(s):  
Oren Levy ◽  
Veit Rothhammer ◽  
Ivan Mascanfroni ◽  
Zhixiang Tong ◽  
Rui Kuai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Inflammation ◽  
Delivery Platform ◽  
A Cell

scholarly journals Viral pre-challenge increases central nervous system inflammation after intracranial interleukin-1β injection

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Yvonne Couch ◽  
Andrew E Davis ◽  
Inês Sá-Pereira ◽  
Sandra J Campbell ◽  
Daniel C Anthony
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Interleukin 1Β ◽  
Central Nervous System Inflammation
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