scholarly journals The influence of parental history of Alzheimer's disease and apolipoprotein E  4 on the BOLD signal during recognition memory

Brain ◽  
2008 ◽  
Vol 132 (2) ◽  
pp. 383-391 ◽  
Author(s):  
G. Xu ◽  
D. G. Mclaren ◽  
M. L. Ries ◽  
M. E. Fitzgerald ◽  
B. B. Bendlin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Recognition Memory ◽  
Apolipoprotein E ◽  
Bold Signal ◽  
Parental History ◽  
History Of

Alzheimer’s Disease and History of Blood Transfusion by Apolipoprotein-E Genotype

1997 ◽  
Vol 16 (2) ◽  
pp. 86-93 ◽  
Author(s):  
E.S. O'Meara ◽  
W.A. Kukull ◽  
G.D. Schellenberg ◽  
J.D. Bowen ◽  
W.C. McCormick ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Transfusion ◽  
Apolipoprotein E ◽  
History Of ◽  
Apolipoprotein E Genotype

scholarly journals APOE4 status is related to differences in memory-related brain function in asymptomatic older adults: Baseline analysis of the PREVENT-AD task fMRI dataset

2019 ◽  
Author(s):  
Sheida Rabipour ◽  
Sricharana Rajagopal ◽  
Elsa Yu ◽  
Stamatoula Pasvanis ◽  
John Breitner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Episodic Memory ◽  
Brain Activity ◽  
Memory Performance ◽  
Group Differences ◽  
Parental History ◽  
History Of ◽  
Spatial Source

AbstractEpisodic memory decline is one of the earliest symptoms of late-onset Alzheimer’s Disease (AD) and older adults with the apolipoprotein E e4 (+APOE4) genetic risk factor for AD may exhibit altered patterns of memory-related brain activity years prior to initial symptom onset. In the current study we report the baseline episodic memory task fMRI results from the PRe-symptomatic EValuation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) study in Montreal, Canada, in which 327 healthy older adults, within 15 years of the parent’s conversion to AD, were scanned. During the task fMRI protocol volunteers were scanned as they encoded and retrieved object-location spatial source associations. The task was designed to discriminate between brain activity related to successful spatial source recollection and failures in spatial source recollection, with memory for only item (object) memory. Multivariate task-related partial least squares (task PLS) was used to test the hypothesis that +APOE4 adults with a family history of AD would exhibit altered patterns of brain activity in the recollection-related memory network, comprised of medial frontal, parietal and medial temporal cortices, compared to APOE4 non-carriers (-APOE4). We also tested for group differences in the correlation between event-related brain activity and memory performance in +APOE4 compared to -APOE4 adults using behavioral-PLS (B-PLS). We found group similarities in memory performance and in task-related brain activity in the recollection network. However, the B-PLS results indicated there were group differences in brain activity-behavior correlations in ventral occipito-temporal, medial temporal, and medial prefrontal cortices during episodic encoding. These findings are consistent with previous literature on the influence of APOE4 on brain activity and provide new perspective on potential gene-based differences in brain-behavior relationships in people with parental history of AD. Future research should further investigate the potential to distinguish risk of AD development based on memory performance and associated patterns of brain activity.

A-5 Examining the Interactive Effects of Traumatic Brain Injury and Apolipoprotein E on Cognitive Decline in Alzheimer’s Disease

2021 ◽  
Vol 36 (6) ◽  
pp. 1044-1044
Author(s):  
Claire Alexander ◽  
Julie Suhr
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Apolipoprotein E ◽  
Negative Impact ◽  
Interactive Effects ◽  
Decline Rate ◽  
History Of ◽  
Positive Effect

Abstract Objective Little research has focused on possible effects of TBI on cognitive decline rate after Alzheimer’s disease (ad) diagnosis. We examined whether Apolipoprotein E (APOE) status and TBI history interact to predict cognitive decline. Method We used data from the National Alzheimer’s Coordinating Centers (N = 463; 42.3% APOE e4 carriers, 7.8% with TBI history, mean baseline age 79.3). Inclusion criteria included normal cognition at baseline with diagnosis of ad at a follow-up visit; baseline age 50 or older; and at least 3 years of follow-up data. Mixed models (random intercept, random slope) were used, with TBI history, APOE status, and their interaction as predictors of interest. Education, race, and history of TIA, stroke, or hypertension were included as covariates. Cognitive measures included mental status exam scores and immediate/delayed story memory. Results After accounting for covariates, TBI history had a positive effect on cognitive decline rate on the screener and immediate memory measures. APOE status did not affect rate of cognitive decline on the screener, but presence of e4 predicted faster decline on immediate and delayed memory. TBI history and APOE status interacted to predict delayed memory decline, such that history of TBI was associated with a reduced rate of decline for e4 non-carriers but there was no effect of TBI for e4 carriers. Conclusion When examining cognitive decline trajectory, TBI history predicted slower decline (a positive effect) while APOE had either a negative impact or no effect, depending on the measure. Future study should examine cognitive decline in the context of demographic and genetic factors.

scholarly journals GWAS on family history of Alzheimer’s disease

2018 ◽  
Author(s):  
Riccardo E. Marioni ◽  
Sarah E. Harris ◽  
Allan F. McRae ◽  
Qian Zhang ◽  
Saskia P. Hagenaars ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Targets ◽  
Genome Wide Association Study ◽  
Warfarin Dose ◽  
Lifestyle Changes ◽  
Self Report ◽  
Parental History ◽  
A Genome ◽  
History Of

AbstractAlzheimer’s disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate the biological underpinnings. Using self-report of parental history of Alzheimer’s dementia for case ascertainment in a genome-wide association study of over 300,000 participants from UK Biobank (32,222 maternal cases, 16,613 paternal cases) and meta-analysing with published consortium data (n=74,046 with 25,580 cases across the discovery and replication analyses), six new AD-associated loci (P<5x10−8) are identified. Three contain genes relevant for AD and neurodegeneration: ADAM10, ADAMTS4, and ACE. Suggestive loci include drug targets such as VKORC1 (warfarin dose) and BZRAP1 (benzodiazepine receptor). We report evidence that association of SNPs and AD at the PVR gene is potentially mediated by both gene expression and DNA methylation in the prefrontal cortex. Our discovered loci may help to elucidate the biological mechanisms underlying AD and, given that many are existing drug targets for other diseases and disorders, warrant further exploration for potential precision medicine applications.

Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease

2020 ◽  
Vol 123 ◽  
pp. 81-88 ◽  
Author(s):  
Inés Del Cerro ◽  
Mirta F. Villarreal ◽  
Carolina Abulafia ◽  
Bárbara Duarte-Abritta ◽  
Stella M. Sánchez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Locus Coeruleus ◽  
Healthy Adults ◽  
Parental History ◽  
History Of

[P2-123]: ASSOCIATION OF CHOLESTEROL AND CHOLESTEROL METABOLISM GENES WITH COGNITIVE FUNCTION IN A POPULATION ENRICHED FOR A PARENTAL HISTORY OF ALZHEIMER's DISEASE

2017 ◽  
Vol 13 (7S_Part_13) ◽  
pp. P654-P654
Author(s):  
Karen K. Lazar ◽  
Rebecca L. Koscik ◽  
Leonelo E. Bautista ◽  
Mark A. Sager ◽  
Bruce P. Hermann ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Cholesterol Metabolism ◽  
Parental History ◽  
History Of
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