scholarly journals Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson's disease patients

Brain ◽  
2008 ◽  
Vol 131 (12) ◽  
pp. 3348-3360 ◽  
Author(s):  
J. L. Alberts ◽  
C. Voelcker-Rehage ◽  
K. Hallahan ◽  
M. Vitek ◽  
R. Bamzai ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Performance ◽  
Subthalamic Stimulation

Modulation of motor cortex by subthalamic stimulation in Parkinson's disease

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
B Haslinger ◽  
K Kalteis ◽  
F Alesch ◽  
H Boecker ◽  
AO Ceballos-Baumann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Subthalamic Stimulation

Comparison of Pallidal and Subthalamic Stimulation on Force Control in Patient's with Parkinson's Disease

Motor Control ◽  
2004 ◽  
Vol 8 (4) ◽  
pp. 484-499 ◽  
Author(s):  
Jay L. Alberts ◽  
Christopher M. Elder ◽  
Michael S. Okun ◽  
Jerrold L. Vitek
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Force Control ◽  
Subthalamic Stimulation

scholarly journals Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease

2018 ◽  
Vol 11 (4) ◽  
pp. 867-874 ◽  
Author(s):  
Haidar Salimi Dafsari ◽  
Luisa Weiß ◽  
Monty Silverdale ◽  
Alexandra Rizos ◽  
Prashanth Reddy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Symptoms ◽  
Short Term ◽  
Subthalamic Stimulation ◽  
Non Motor Symptoms

scholarly journals Urinary dysfunction with detrusor hyperactivity in women with Parkinson's disease cannot be blamed as a factor of worsening motor performance

2013 ◽  
Vol 71 (9A) ◽  
pp. 591-595 ◽  
Author(s):  
Raimundo Nonato Campos-Sousa ◽  
Elizabeth Maria Aparecida Barasnevicius Quagliato ◽  
Kelson James Almeida ◽  
Inacio Augusto Dias de Castro ◽  
Viriato Campelo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Performance ◽  
Rating Scale ◽  
Clinical Symptoms ◽  
Urinary Dysfunction ◽  
Clinical Aspects ◽  
Yahr Scale ◽  
Disease Rating ◽  
Detrusor Hyperactivity

Introduction Detrusor hyperactivity is the leading cause of urinary dysfunction in Parkinson's disease (PD). There are few studies correlating PD clinical aspects with this autonomic feature. Methods A cohort of 63 women with PD were prospectively examined for assessment of clinical aspects and disease severity using unified Parkinson's disease rating scale and Hoehn-Yahr scale, respectively. The urologic function was evaluated by the urodynamic study. Two groups were categorized at this time - groups with and without detrusor hyperactivity. After seven years, the same parameters were re-evaluated. Results Progression of the disease on mental scores was found in the group with detrusor hyperactivity. On follow-up, clinical symptoms and severity did not show significant worsening between the groups. Conclusion Detrusor hyperactivity is a frequent urodynamic finding in PD, and even though it is associated with dopaminergic dysfunction, it cannot be blamed as a factor of worsening motor performance, but is probably associated with poor cognitive and mental prognosis.

scholarly journals Bilateral but not unilateral subthalamic stimulation promotes apathy: a translational study in rodents and Parkinson’s disease patients

2020 ◽  
Author(s):  
Yvan Vachez ◽  
Marie Bahout ◽  
Robin Magnard ◽  
Pierre-Maxime David ◽  
Carole Carcenac ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acute Effect ◽  
Recent Experimental Data ◽  
Translational Study ◽  
Clinical Center ◽  
Subthalamic Stimulation ◽  
Operative Assessment ◽  
Stn Dbs

ABSTRACTApathy is frequently reported in Parkinson’s disease (PD) patients under subthalamic nucleus deep brain stimulation (STN-DBS). The prevailing clinical view for apathy following STN-DBS is the reduction of dopaminergic medication. However, few clinical reports and recent experimental data suggested the pathogenicity of bilateral STN-DBS on motivation, challenging the leading opinion. Here, we investigate whether bilateralism of STN-DBS influences apathy outcome after STN-DBS, combining pre-clinical and clinical approaches. We assess the motivational effects of chronic unilateral STN-DBS in rats in the exact same conditions having highlighted a loss of motivation under bilateral STN-DBS. Clinical data are obtained by the follow-up of a cohort of parkinsonian patients undergoing unilateral STN-DBS and coming from the clinical center that described apathy related to bilateral STN-DBS itself. Despite an acute effect, which fades rapidly, unilateral STN-DBS did not induce a loss of motivation reminiscent to apathy in rats. In patients, apathy did not increase between the preoperative and the post-operative assessment. Together, those data demonstrate that bilateral but not unilateral STN-DBS can induce a loss of motivation in both rats and patients. This constitutes another evidence of the role of STN-DBS itself for apathy in PD.

Sex, Food and Threat: Startling Changes after Subthalamic Stimulation in Parkinson's Disease

2013 ◽  
Vol 6 (5) ◽  
pp. 740-745 ◽  
Author(s):  
Tereza Serranová ◽  
Tomáš Sieger ◽  
Petr Dušek ◽  
Filip Růžička ◽  
Dušan Urgošík ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Stimulation

scholarly journals Increased neuromuscular consistency in gait and balance after partnered, dance-based rehabilitation in Parkinson’s disease

2017 ◽  
Vol 118 (1) ◽  
pp. 363-373 ◽  
Author(s):  
Jessica L. Allen ◽  
J. Lucas McKay ◽  
Andrew Sawers ◽  
Madeleine E. Hackney ◽  
Lena H. Ting
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Skill ◽  
Motor Performance ◽  
Neuromuscular Control ◽  
Muscle Coordination ◽  
Short Term ◽  
Behavioral Measures ◽  
Motor Module ◽  
Reactive Balance

Here we examined changes in muscle coordination associated with improved motor performance after partnered, dance-based rehabilitation in individuals with mild to moderate idiopathic Parkinson’s disease. Using motor module (a.k.a. muscle synergy) analysis, we identified changes in the modular control of overground walking and standing reactive balance that accompanied clinically meaningful improvements in behavioral measures of balance, gait, and disease symptoms after 3 wk of daily Adapted Tango classes. In contrast to previous studies that revealed a positive association between motor module number and motor performance, none of the six participants in this pilot study increased motor module number despite improvements in behavioral measures of balance and gait performance. Instead, motor modules were more consistently recruited and distinctly organized immediately after rehabilitation, suggesting more reliable motor output. Furthermore, the pool of motor modules shared between walking and reactive balance increased after rehabilitation, suggesting greater generalizability of motor module function across tasks. Our work is the first to show that motor module distinctness, consistency, and generalizability are more sensitive to improvements in gait and balance function after short-term rehabilitation than motor module number. Moreover, as similar differences in motor module distinctness, consistency, and generalizability have been demonstrated previously in healthy young adults with and without long-term motor training, our work suggests commonalities in the structure of muscle coordination associated with differences in motor performance across the spectrum from motor impairment to expertise. NEW & NOTEWORTHY We demonstrate changes in neuromuscular control of gait and balance in individuals with Parkinson’s disease after short-term, dance-based rehabilitation. Our work is the first to show that motor module distinctness, consistency, and generalizability across gait and balance are more sensitive than motor module number to improvements in motor performance following short-term rehabilitation. Our results indicate commonalities in muscle coordination improvements associated with motor skill reacquisition due to rehabilitation and motor skill acquisition in healthy individuals.

Effect of STN-DBS frequency on cortical excitability and motor performance in Parkinson's disease

2019 ◽  
Vol 49 (6) ◽  
pp. 431
Author(s):  
André Zacharia ◽  
Isabel Sastre-Bataller ◽  
Dejan Georgiev ◽  
Ludvic Zrinzo ◽  
Marwan Hariz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Performance ◽  
Cortical Excitability ◽  
Stn Dbs
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