scholarly journals Spectroscopic axonal damage of the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclerosis

Brain ◽  
2004 ◽  
Vol 127 (1) ◽  
pp. 89-98 ◽  
Author(s):  
M. Gadea
Keyword(s):  
Multiple Sclerosis ◽  
Selective Attention ◽  
Locus Coeruleus ◽  
Early Stage ◽  
Axonal Damage ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
The Right ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Attention Impairment

scholarly journals Dysarthria and dysphagia due to the opercular syndrome in multiple sclerosis

2007 ◽  
Vol 13 (6) ◽  
pp. 817-819 ◽  
Author(s):  
M.P. Pender ◽  
S.M. Ferguson
Keyword(s):  
Multiple Sclerosis ◽  
Relapsing Remitting ◽  
Opercular Syndrome ◽  
Remitting Multiple Sclerosis ◽  
The Right ◽  
Relapsing Remitting Multiple Sclerosis

We report a patient with relapsing-remitting multiple sclerosis (RRMS), who developed bilateral severe tongue weakness due to the anterior opercular syndrome. This was caused by a recent inflammatory demyelinating lesion in the right perisylvian juxtacortical region, superimposed on a pre-existing left perisylvian lesion, which had previously caused temporary isolated right tongue weakness. Multiple Sclerosis 2007; 13: 817-819. http://msj.sagepub.com

Axonal Degeneration Independent of Inflammatory Activity: Is It More Intense in the Early Stages of Relapsing-Remitting Multiple Sclerosis Disease?

2020 ◽  
Vol 83 (5) ◽  
pp. 508-516
Author(s):  
Vedat Cilingir ◽  
Muhammed Batur
Keyword(s):  
Multiple Sclerosis ◽  
Axonal Degeneration ◽  
Early Stage ◽  
Early Years ◽  
Inflammatory Activity ◽  
Control Group ◽  
Relapsing Remitting ◽  
Duration Of Disease ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

<b><i>Background:</i></b> This study aimed to investigate whether there are differences in the axonal degeneration rate between patients in the early years of relapsing-remitting multiple sclerosis (RRMS) disease and RRMS patients in their later years. <b><i>Methods:</i></b> The early-stage RRMS patients (EMS) group had 65 patients whose duration of disease was within 3 years from the date of the first attack. The late-stage RRMS patients (LMS) group had 69 patients whose duration of disease was within the range of 3–10 years from the date of the first attack. In addition, a control group was composed of 32 healthy subjects. Peripapillary retinal nerve fiber layer (RNFL) thickness was monitored with spectral-domain OCT in all included patients for approximately 3 years. <b><i>Results:</i></b> The annual RNFL atrophy rate (aRNFLr) in the EMS group was −1.246 ± 0.778 μm/year, the aRNFLr in the LMS group was −0.898 ± 0.536 μm/year, and the aRNFLr was −0.234 ± 0.154 μm/year in the control group (<i>p</i> &#x3c; 0.001). The aRNFLr in the EMS group was significantly higher than the aRNFLr in the LMS group (<i>p</i> = 0.01). The aRNFLr was not associated with MRI activity or the condition of having an attack. There was a correlation between Expanded Disability Status Scale (EDSS) progression and aRNFLr in both the EMS and LMS patient groups (<i>r</i> = −0.471, <i>p</i> &#x3c; 0.001, and <i>r</i> = −0.567, <i>p</i> &#x3c; 0.001, respectively). <b><i>Conclusion:</i></b> The axonal degeneration rate is faster in RRMS patients in the first years of the disease than in later years. In addition, axonal degeneration occurs independently of inflammatory activity. Axonal degeneration is correlated with disability progression, but not with inflammatory findings, such as clinical episodes and MRI activity.

Perception of affective prosody in patients at an early stage of relapsing-remitting multiple sclerosis

2012 ◽  
Vol 7 (1) ◽  
pp. 91-106 ◽  
Author(s):  
Markus Kraemer ◽  
Michele Herold ◽  
Jennifer Uekermann ◽  
Bernhard Kis ◽  
Irene Daum ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Early Stage ◽  
Affective Prosody ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals Attention impairment associated with relapsing-remitting multiple sclerosis patients with mild incapacity

2007 ◽  
Vol 65 (2A) ◽  
pp. 262-267 ◽  
Author(s):  
Silvia Balsimelli ◽  
Maria Fernanda Mendes ◽  
Paulo H.F. Bertolucci ◽  
Charles Peter Tilbery
Keyword(s):  
Multiple Sclerosis ◽  
Digit Span ◽  
Stroop Test ◽  
Central Processing ◽  
Significant Difference ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Attention Impairment

Neuropsychological studies have consistently reported cognitive dysfunctions associated with multiple sclerosis. One-hundred fifteen subjects with relapsing-remitting multiple sclerosis (RRMS) were compared with forty health controls according to a neuropsychological test battery, which included digit span, trail making, cancellation and stroop test. Both groups were matched for age, sex and educational level. Subjects with RRMS had a worse performance the speed of response. Subjects with RRMS spent more time to complete the test in either sections A (p=0.001) or B (p=0.001), although there was no significant difference in terms of number of errors. The total time required to finish the Stroop test was higher for subjects with RRMS (p<0.001), being the time difference between groups significant at trial 4 (p<0.001). Attention impairment in subjects with RRMS is related to slowed central processing, which may be affected in all stages, including impairment of automatic and controlled processing of information and in the motor program.

Multimodal evoked potentials measure and predict disability progression in early relapsing–remitting multiple sclerosis

2008 ◽  
Vol 14 (4) ◽  
pp. 553-556 ◽  
Author(s):  
P Jung ◽  
A Beyerle ◽  
U Ziemann
Keyword(s):  
Multiple Sclerosis ◽  
Early Stage ◽  
Expanded Disability Status Scale ◽  
Disability Progression ◽  
Multiple Sclerosis Functional Composite ◽  
Disability Status ◽  
Relapsing Remitting ◽  
Multimodal Evoked Potentials ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

In 37 patients with early relapsing–remitting multiple sclerosis (RRMS), a multimodal EP score (mEPS) and clinical scores (Expanded Disability Status Scale (EDSS) and multiple sclerosis functional composite (MSFC)) were obtained prospectively over 24 months. Changes in mEPS correlated with changes in EDSS (Spearman’s ρ = 0.69, p < 0.0001) and MSFC (ρ = –0.41, p < 0.02). Patients with relevant EDSS progression ( n = 7) showed stronger mEPS deterioration than clinically stable patients (10.8 ± 3.2 versus 1.3 ± 0.8, p < 0.005). Baseline mEPS was not significantly correlated with baseline EDSS but with EDSS after 24 months (ρ = 0.39, p < 0.02). The data suggest that serial mEPS measure and moderately predict clinically relevant disease activity in the therapeutically most relevant early stage of RRMS.

Theory of mind and empathy in patients at an early stage of relapsing remitting multiple sclerosis

2013 ◽  
Vol 115 (7) ◽  
pp. 1016-1022 ◽  
Author(s):  
Markus Kraemer ◽  
Michèle Herold ◽  
Jennifer Uekermann ◽  
Bernhard Kis ◽  
Jens Wiltfang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Theory Of Mind ◽  
Early Stage ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis
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