scholarly journals Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination

Brain ◽  
2003 ◽  
Vol 126 (7) ◽  
pp. 1552-1561 ◽  
Author(s):  
M. J. Craner
Keyword(s):  
Optic Nerve ◽  
Sodium Channel ◽  
Channel Distribution

Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons

Glia ◽  
2003 ◽  
Vol 44 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Matthew N. Rasband ◽  
Christopher M. Taylor ◽  
Rashmi Bansal
Keyword(s):  
Optic Nerve ◽  
Sodium Channel ◽  
Sodium Channel Clustering

Sodium channel expression detected with antibody 7493 in A2B5+ and A2B5? astrocytes from rat optic nerve in vitro

Glia ◽  
1990 ◽  
Vol 3 (5) ◽  
pp. 358-367 ◽  
Author(s):  
J. E. Minturn ◽  
J. A. Black ◽  
K. J. Angelides ◽  
S. G. Waxman
Keyword(s):  
Optic Nerve ◽  
Sodium Channel ◽  
Channel Expression

Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice

1997 ◽  
Vol 50 (2) ◽  
pp. 321-336 ◽  
Author(s):  
Ian Vabnick ◽  
Albee Messing ◽  
S.Y. Chiu ◽  
S. Rock Levinson ◽  
Melitta Schachner ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Mutant Mice ◽  
Null Mutant ◽  
Channel Distribution ◽  
Null Mutant Mice

Sodium channel distribution in a spider mechanosensory organ

1995 ◽  
Vol 683 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Ernst-August Seyfarth ◽  
Esmond J. Sanders ◽  
Andrew S. French
Keyword(s):  
Sodium Channel ◽  
Channel Distribution

Sodium channel expression in optic nerve astrocytes chronically deprived of axonal contact

Glia ◽  
1992 ◽  
Vol 6 (1) ◽  
pp. 19-29 ◽  
Author(s):  
J. E. Minturn ◽  
H. Sontheimer ◽  
J. A. Black ◽  
B. R. Ranson ◽  
S. G. Waxman
Keyword(s):  
Optic Nerve ◽  
Sodium Channel ◽  
Channel Expression

Immuno-ultrastructural localization of sodium channels at nodes of Ranvier and perinodal astrocytes in rat optic nerve

1989 ◽  
Vol 238 (1290) ◽  
pp. 39-51 ◽  
Keyword(s):  
Optic Nerve ◽  
Sodium Channel ◽  
Sodium Channels ◽  
Node Of Ranvier ◽  
Ultrastructural Localization ◽  
Active Role ◽  
Nodes Of Ranvier ◽  
Electron Microscopic ◽  
Axon Membrane ◽  
Intense Immunoreactivity

Immuno-electron microscopic localization of sodium channels at nodes of Ranvier within adult optic nerve was demonstrated with polyclonal antibody 7493. The 7493 antisera, which is directed against purified sodium channels from rat brain, recognizes a 260 kDa protein in immunoblots of the crude glycoprotein fraction from adult rat optic nerve. Intense immunoreactivity with 7493 antisera was observed at nodes of Ranvier. Axon membrane at the node was densely stained, whereas paranodal and internodal axon membrane did not exhibit immunoreactivity. The axoplasm beneath the nodal membrane displayed variable immunostaining. Neither terminal paranodal oligodendroglial loops nor oligodendrocyte plasmalemma were immunoreactive with 7493 antisera. However, perinodal astrocyte processes exhibited intense immunoreactivity with the anti-sodium channel antisera. Optic nerves incubated with pre-immune sera, or with 7493 antisera that had been pre-adsorbed with purified sodium channel protein, displayed no immunoreactivity. These results demonstrate localization of sodium channels at high density at mammalian nodes of Ranvier and in some perinodal astrocyte processes. The latter observation offers support for an active role for perinodal astrocyte processes in the aggregation of sodium channels within the axon membrane at the node of Ranvier.

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