scholarly journals Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: A clue to the pathophysiology of akinesia?

Brain ◽  
2003 ◽  
Vol 126 (1) ◽  
pp. 95-114 ◽  
Author(s):  
L. Escola ◽  
Th. Michelet ◽  
F. Macia ◽  
D. Guehl ◽  
B. Bioulac ◽  
...  
Keyword(s):  
Information Processing ◽  
Supplementary Motor Area ◽  
Motor Area

scholarly journals Cognitive capacity limits are remediated by practice-induced plasticity between the Putamen and Pre-Supplementary Motor Area

2019 ◽  
Author(s):  
K.G. Garner ◽  
M.I. Garrido ◽  
P.E. Dux
Keyword(s):  
Decision Making ◽  
Information Processing ◽  
Information Sharing ◽  
Information Transfer ◽  
Supplementary Motor Area ◽  
Cortical Network ◽  
Motor Area ◽  
Cognitive Capacity ◽  
Capacity Limits ◽  
Stimulus Response

AbstractHumans show striking limitations in information processing when multitasking, yet can modify these limits with practice. Such limitations have been linked to a frontal-parietal network, but recent models of decision-making implicate a striatal-cortical network. We adjudicated these accounts by investigating the circuitry underpinning multitasking in 100 individuals and the plasticity caused by practice. We observed that multitasking costs, and their practice induced remediation, are best explained by modulations in information transfer between the striatum and the cortical areas that represent stimulus-response mappings. Specifically, our results support the view that multitasking stems at least in part from taxation in information sharing between the putamen and pre-supplementary motor area (pre-SMA). Moreover, we propose that modulations to information transfer between these two regions leads to practice-induced improvements in multitasking.Significance statementHumans show striking limitations in information processing when multitasking, yet can modify these limits with practice. Such limitations have been linked to a frontal-parietal network, but recent models of decision-making implicate a striatal-cortical network. We adjudicated these accounts by investigating the circuitry underpinning multitasking in 100 individuals and the plasticity caused by practice. Our results support the view that multitasking stems at least in part from taxation in information sharing between the putamen and pre-supplementary motor area (pre-SMA). We therefore show that models of cognitive capacity limits must consider how subcortical and cortical structures interface to produce cognitive behaviours, and we propose a novel neurophysiological substrate of multitasking limitations.

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