scholarly journals Occurrence and characterization of peripheral nerve involvement in neurofibromatosis type 2

Brain ◽  
2002 ◽  
Vol 125 (5) ◽  
pp. 996-1004 ◽  
Author(s):  
A. D. Sperfeld ◽  
C. Hein ◽  
J. M. Schröder ◽  
A. C. Ludolph ◽  
C. O. Hanemann
Keyword(s):  
Peripheral Nerve ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Nerve Involvement ◽  
Peripheral Nerve Involvement

Nerve ultrasound shows subclinical peripheral nerve involvement in neurofibromatosis type 2

2017 ◽  
Vol 57 (2) ◽  
pp. 312-316 ◽  
Author(s):  
Johan A. Telleman ◽  
Menno D. Stellingwerff ◽  
Geert J. Brekelmans ◽  
Leo H. Visser
Keyword(s):  
Peripheral Nerve ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Nerve Ultrasound ◽  
Nerve Involvement ◽  
Peripheral Nerve Involvement

Malignant peripheral nerve sheath tumor: Transformation in a patient with neurofibromatosis type 2

2018 ◽  
Vol 66 (2) ◽  
pp. e27520 ◽  
Author(s):  
Laura Agresta ◽  
Ralph Salloum ◽  
Trent R. Hummel ◽  
Nancy Ratner ◽  
Francesco T. Mangano ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Tumor Transformation

Isolation and Characterization of Schwann Cells from Neurofibromatosis Type 2 Patients

1998 ◽  
Vol 5 (1) ◽  
pp. 55-64 ◽  
Author(s):  
C. Rosenbaum ◽  
L. Kluwe ◽  
V.F. Mautner ◽  
R.E. Friedrich ◽  
H.W. Müller ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Isolation And Characterization

scholarly journals Long-term Follow-up and Histological Correlation of Peripheral Nervous System Alterations in Neurofibromatosis Type 2

2021 ◽  
Author(s):  
Tim Godel ◽  
Philipp Bäumer ◽  
Said Farschtschi ◽  
Klaus Püschel ◽  
Barbara Hofstadler ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Peripheral Nervous System ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Nerve Lesions ◽  
Peripheral Nerve Lesions

Abstract Purpose To examine long-term alterations of the dorsal root ganglia (DRG) and the peripheral nerve in patients with neurofibromatosis type 2 (NF2) by in vivo high-resolution magnetic resonance neurography (MRN) and their correlation to histology. Methods In this prospective study the lumbosacral DRG, the right sciatic, tibial, and peroneal nerves were examined in 6 patients diagnosed with NF2 and associated polyneuropathy (PNP) by a standardized MRN protocol at 3 T. Volumes of DRG L3–S2 as well as peripheral nerve lesions were assessed and compared to follow-up examinations after 14–100 months. In one patient, imaging findings were further correlated to histology. Results Follow-up MRN examination showed a non-significant increase of volume for the DRG L3: +0.41% (p = 0.10), L4: +22.41% (p = 0.23), L5: +3.38% (p = 0.09), S1: +10.63% (p = 0.05) and S2: +1.17% (p = 0.57). Likewise, peripheral nerve lesions were not significantly increased regarding size (2.18 mm2 vs. 2.15 mm2, p = 0.89) and number (9.00 vs. 9.33, p = 0.36). Histological analyses identified schwannomas as the major correlate of both DRG hyperplasia and peripheral nerve lesions. For peripheral nerve microlesions additionally clusters of onion-bulb formations were identified. Conclusion Peripheral nervous system alterations seem to be constant or show only a minor increase in adult NF2. Thus, symptoms of PNP may not primarily attributed to the initial schwannoma growth but to secondary long-term processes, with symptoms only occurring if a certain threshold is exceeded. Histology identified grouped areas of Schwann cell proliferations as the correlate of DRG hyperplasia, while for peripheral nerve lesions different patterns could be found.

Acute flaccid weakness with myelopathy and peripheral nerve involvement in 2 children: Recent characterization of a previously observed phenomenon

2016 ◽  
Vol 20 (6) ◽  
pp. 948-952 ◽  
Author(s):  
Gemma Olive ◽  
Antonia Clarke ◽  
Katja Doerholt ◽  
Vasantha Gowda ◽  
Atta Siddiqui ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Involvement ◽  
Peripheral Nerve Involvement
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