scholarly journals Increased free water in the substantia nigra in idiopathic REM sleep behaviour disorder

Brain ◽  
2021 ◽  
Author(s):  
Liche Zhou ◽  
Guanglu Li ◽  
Yuyao Zhang ◽  
Miao Zhang ◽  
Zhichun Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Substantia Nigra ◽  
Rem Sleep ◽  
Free Water ◽  
Behaviour Disorder ◽  
Control Subjects ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder ◽  
Healthy Control ◽  
Water Values

Abstract Imaging markers sensitive to neurodegeneration in the substantia nigra are critically needed for future disease-modifying trials. Previous studies have demonstrated the utility of posterior substantia nigra free water as a marker of progression in Parkinson’s disease. In this study, we tested the hypothesis that free water is elevated in the posterior substantia nigra of idiopathic REM sleep behaviour disorder, which is considered a prodromal stage of synucleinopathy. We applied free-water imaging to 32 healthy control subjects, 34 patients with idiopathic REM sleep behaviour disorder and 38 patients with Parkinson’s disease. Eighteen healthy control subjects and 22 patients with idiopathic REM sleep behaviour disorder were followed up and completed longitudinal free-water imaging. Free-water values in the substantia nigra were calculated for each individual and compared among groups. We tested the associations between posterior substantia nigra free water and uptake of striatal dopamine transporter in idiopathic REM sleep behaviour disorder. Free-water values in the posterior substantia nigra were significantly higher in the patients with idiopathic REM sleep behaviour disorder patients than in the healthy control subjects, but were significantly lower in patients with idiopathic REM sleep behaviour disorder than in patients with Parkinson’s disease. In addition, we observed significantly negative associations between posterior substantia nigra free-water values and dopamine transporter striatal binding ratios in the idiopathic REM sleep behaviour disorder patients. Longitudinal free-water imaging analyses were conducted with a linear mixed-effects model, and showed a significant Group × Time interaction in posterior substantia nigra, identifying increased mean free-water values in posterior substantia nigra of idiopathic REM sleep behaviour disorder over time. These results demonstrate that free water in the posterior substantia nigra is a valid imaging marker of neurodegeneration in idiopathic REM sleep behaviour disorder, which has the potential to be used as an indicator in disease-modifying trials.

scholarly journals VMAT2 availability in Parkinson’s disease with probable REM sleep behaviour disorder

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Mikaeel Valli ◽  
Sang Soo Cho ◽  
Carme Uribe ◽  
Mario Masellis ◽  
Robert Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Rem Sleep ◽  
Radioligand Binding ◽  
Striatal Dopamine ◽  
Behaviour Disorder ◽  
Group Condition ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

AbstractREM sleep behaviour disorder (RBD) can be an early non-motor symptom of Parkinson’s disease (PD) with pathology involving mainly the pontine nuclei. Beyond the brainstem, it is unclear if RBD patients comorbid with PD have more affected striatal dopamine denervation compared to PD patients unaffected by RBD (PD-RBD−). To elucidate this, we evaluated the availability of vesicular monoamine transporter 2 (VMAT2), an index of nigrostriatal dopamine innervation, in 15 PD patients with probable RBD (PD-RBD+), 15 PD-RBD−, and 15 age-matched healthy controls (HC) using [11C]DTBZ PET imaging. This technique measured VMAT2 availability within striatal regions of interest (ROI). A mixed effect model was used to compare the radioligand binding of VMAT2 between the three groups for each striatal ROI, while co-varying for sex, cognitive function and depression scores. Multiple regressions were also computed to predict clinical measures from group condition and VMAT2 binding within all ROIs explored. We observed a significant main effect of group condition on VMAT2 availability within the caudate, putamen, ventral striatum, globus pallidus, substantia nigra, and subthalamus. Specifically, our results revealed that PD-RBD+ had lower VMAT2 availability compared to HC in all these regions except for the subthalamus and substantia nigra, while PD-RBD− was significantly lower than HC in all these regions. PD-RBD− showed a negative relationship between motor severity and VMAT2 availability within the left caudate. Our findings reflect that both PD patient subgroups had similar denervation within the nigrostriatal pathway. There were no significant interactions detected between radioligand binding and clinical scores in PD-RBD+. Taken together, VMAT2 and striatal dopamine denervation in general may not be a significant contributor to the pathophysiology of RBD in PD patients. Future studies are encouraged to explore other underlying neural chemistry mechanisms contributing to RBD in PD patients.

scholarly journals Parkinson’s Disease with and without REM Sleep Behaviour Disorder: Are There Any Clinical Differences?

2009 ◽  
Vol 61 (3) ◽  
pp. 164-170 ◽  
Author(s):  
Asako Yoritaka ◽  
Hideki Ohizumi ◽  
Shigeki Tanaka ◽  
Nobutaka Hattori
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rem Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

scholarly journals Evolution of prodromal Parkinson’s disease and dementia with Lewy bodies: a prospective study

Brain ◽  
2019 ◽  
Vol 142 (7) ◽  
pp. 2051-2067 ◽  
Author(s):  
Seyed-Mohammad Fereshtehnejad ◽  
Chun Yao ◽  
Amelie Pelletier ◽  
Jacques Y Montplaisir ◽  
Jean-François Gagnon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rem Sleep ◽  
Colour Vision ◽  
Rating Scale ◽  
Lewy Bodies ◽  
Behaviour Disorder ◽  
Mixed Effect ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

Abstract Parkinson’s disease has a long prodromal stage with various subclinical motor and non-motor manifestations; however, their evolution in the years before Parkinson’s disease is diagnosed is unclear. We traced the evolution of early motor and non-motor manifestations of synucleinopathy from the stage of idiopathic rapid eye movement (REM) sleep behaviour disorder until defined neurodegenerative disease. During 2004–16, we recruited and then annually followed 154 polysomnography-proven patients with idiopathic REM sleep behaviour disorder, of whom 55 phenoconverted to defined parkinsonism or dementia. Longitudinal data on multiple prodromal features, including the Unified Parkinson’s Disease Rating Scale parts I–III, quantitative motor tests, olfaction, colour vision, cognition, and autonomic functions were gathered annually (average = five follow-up visits, range: 2–12 years). The same measures were also assessed in 102 age- and sex-matched healthy control subjects. By looking backward from the time of dementia or parkinsonism diagnosis, we examined trajectories of each prodromal feature using mixed effect models. Based on analysis, olfactory loss was first to develop, with predicted onset >20 years before phenoconversion. This was followed by impaired colour vision, constipation, and erectile dysfunction, starting 10–16 years prior to phenoconversion. At 7–9 years before phenoconversion, slight urinary dysfunction and subtle cognitive decline could be detected. Among motor symptoms altered handwriting, turning in bed, walking, salivation, speech, and facial expression began to be disrupted starting 7–11 years prior to parkinsonism diagnosis, but remained mild until soon before phenoconversion. Motor examination abnormalities began 5–7 years before phenoconversion, with the alternate tap test having the longest interval (8 years before phenoconversion). Among cardinal motor phenotypes, bradykinesia appeared first, ∼5–6 years prior to phenoconversion, followed by rigidity (Year −3) and tremor (Year −2). With direct prospective evaluation of an idiopathic REM sleep behaviour disorder cohort during phenoconversion, we documented an evolution of prodromal manifestations similar to that predicted by pathological staging models, with predicted prodromal intervals as long as 20 years.

Probable REM sleep behaviour disorder and STN-DBS outcome in Parkinson's Disease

2010 ◽  
Vol 16 (4) ◽  
pp. 265-269 ◽  
Author(s):  
M. Zibetti ◽  
L. Rizzi ◽  
L. Colloca ◽  
A. Cinquepalmi ◽  
S. Angrisano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rem Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder ◽  
Stn Dbs

scholarly journals Microstructural Changes in Patients With Parkinson's Disease Comorbid With REM Sleep Behaviour Disorder and Depressive Symptoms

2018 ◽  
Vol 9 ◽  
Author(s):  
Farzaneh Ghazi Sherbaf ◽  
Yasna Rostam Abadi ◽  
Mahtab Mojtahed Zadeh ◽  
Amir Ashraf-Ganjouei ◽  
Hossein Sanjari Moghaddam ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Depressive Symptoms ◽  
Rem Sleep ◽  
Behaviour Disorder ◽  
Microstructural Changes ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder
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