scholarly journals Erratum to: Gamma subunit of complement component 8 is a neuroinflammation inhibitor

Brain ◽  
2021 ◽  
Keyword(s):  
Complement Component ◽  
Gamma Subunit

scholarly journals Gamma subunit of complement component 8 is a neuroinflammation inhibitor

Brain ◽  
2020 ◽  
Author(s):  
Jong-Heon Kim ◽  
Ruqayya Afridi ◽  
Jin Han ◽  
Hyun-Gug Jung ◽  
Seung-Chan Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurological Diseases ◽  
Complement Component ◽  
Complement Components ◽  
Gamma Subunit ◽  
Small Proteins ◽  
Sphingosine 1 Phosphate ◽  
The Complement System

Abstract The complement system is part of the innate immune system that comprises several small proteins activated by sequential cleavages. The majority of these complement components, such as components 3a (C3a) and C5a, are chemotactic and pro-inflammatory. However, in this study, we revealed an inhibitory role of complement component 8 gamma (C8G) in neuroinflammation. In patients with Alzheimer's disease, who exhibit strong neuroinflammation, we found higher C8G levels in brain tissue, CSF, and plasma. Our novel findings also showed that the expression level of C8G increases in the inflamed mouse brain, and that C8G is mainly localized to brain astrocytes. Experiments using recombinant C8G protein and shRNA-mediated knockdown showed that C8G inhibits glial hyperactivation, neuroinflammation, and cognitive decline in acute and chronic animal models of Alzheimer’s disease. Additionally, we identified sphingosine-1-phosphate receptor 2 (S1PR2) as a novel interaction protein of C8G and demonstrated that astrocyte-derived C8G interacts with S1PR2 to antagonize the pro-inflammatory action of S1P in microglia. Taken together, our results reveal the previously unrecognized role of C8G as a neuroinflammation inhibitor. Our findings pave the way towards therapeutic containment of neuroinflammation in Alzheimer’s disease and related neurological diseases.

Neutralizing the complement component C5a protects against lung injury and extrapulmonary organ injury in pneumococcal pneumonia induced sepsis

Pneumologie ◽  
2014 ◽  
Vol 68 (S 01) ◽  
Author(s):  
H Müller-Redetzky ◽  
U Henke-Kellermann ◽  
T Tschernig ◽  
S Wienhold ◽  
M Polikarpova ◽  
...  
Keyword(s):  
Lung Injury ◽  
Pneumococcal Pneumonia ◽  
Complement Component ◽  
Organ Injury
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