PHYSIOLOGICAL OBSERVATIONS IN STEREOTAXIC OPERATIONS IN EXTRAPYRAMIDAL MOTOR DISTURBANCES

Brain ◽  
1960 ◽  
Vol 83 (2) ◽  
pp. 337-350 ◽  
Author(s):  
R. HASSLER ◽  
T. RIECHERT ◽  
F. MUNDINGER ◽  
W. UMBACH ◽  
J. A. GANGLBERGER
Keyword(s):  
Extrapyramidal Motor ◽  
Motor Disturbances

Progressive cerebellar and extrapyramidal motor disturbances in galactosaemic twins

1986 ◽  
Vol 145 (5) ◽  
pp. 413-417 ◽  
Author(s):  
H. B�hles ◽  
D. Wenzel ◽  
Y. S. Shin
Keyword(s):  
Extrapyramidal Motor ◽  
Motor Disturbances

Cognitive Dysfunction in Schizophrenia: Maze-Solving Behavior in Treated and Untreated Patients

CNS Spectrums ◽  
1997 ◽  
Vol 2 (8) ◽  
pp. 26-40 ◽  
Author(s):  
B. Gallhofer ◽  
S. Krieger ◽  
S. Lis ◽  
L. Hargarter ◽  
C. Roder ◽  
...  
Keyword(s):  
Cognitive Processing ◽  
Treatment Strategies ◽  
Maze Task ◽  
Psychopharmacological Treatment ◽  
Schizophrenic Patients ◽  
Extrapyramidal Motor ◽  
Insight Into ◽  
Cognitive Disturbance ◽  
Over Time ◽  
Motor Disturbances

AbstractIn this article, we present data on the analysis of maze-solving behavior as a tool for the investigation of cognitive disturbance in schizophrenic patients. Solving maze tasks efficiently requires both an interaction between and an integration of perceptive and action-oriented processes. Starting from the hypothesis that these domains are preferentially disturbed in schizophrenia, we propose that the maze-solving behavior of schizophrenic patients permits insight into specific impairments in disease-related cognitive processing. We present the results of a maze task study comparing medication-free schizophrenic patients and matched healthy controls. This analysis forms the basis for an investigation of the influence of psychopharmacological treatment strategies on the observed behavior in the maze-solving paradigm. Finally, a third study concerned with improvement over time associated with medication is presented, and possible influences of extrapyramidal motor disturbances on schizophrenic patients' maze performance are discussed.

Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping

2020 ◽  
Vol 132 (6) ◽  
pp. 1683-1691 ◽  
Author(s):  
Kazuya Motomura ◽  
Lushun Chalise ◽  
Fumiharu Ohka ◽  
Kosuke Aoki ◽  
Kuniaki Tanahashi ◽  
...  
Keyword(s):  
Working Memory ◽  
Brain Mapping ◽  
Functional Outcomes ◽  
Digit Span ◽  
Awake Surgery ◽  
Motor Deficit ◽  
Lower Grade ◽  
Superior Frontal Gyrus ◽  
Neurocognitive Functions ◽  
Motor Disturbances

OBJECTIVELower-grade gliomas (LGGs) are often observed within eloquent regions, which indicates that tumor resection in these areas carries a potential risk for neurological disturbances, such as motor deficit, language disorder, and/or neurocognitive impairments. Some patients with frontal tumors exhibit severe impairments of neurocognitive function, including working memory and spatial awareness, after tumor removal. The aim of this study was to investigate neurocognitive and functional outcomes of frontal LGGs in both the dominant and nondominant hemispheres after awake brain mapping.METHODSData from 50 consecutive patients with diffuse frontal LGGs in the dominant and nondominant hemispheres who underwent awake brain surgery between December 2012 and September 2018 were retrospectively analyzed. The goal was to map neurocognitive functions such as working memory by using working memory tasks, including digit span testing and N-back tasks.RESULTSDue to awake language mapping, the frontal aslant tract was frequently identified as a functional boundary in patients with left superior frontal gyrus tumors (76.5%). Furthermore, functional boundaries were identified while evaluating verbal and spatial working memory function by stimulating the dorsolateral prefrontal cortex using the digit span and visual N-back tasks in patients with right superior frontal gyrus tumors (7.1%). Comparing the preoperative and postoperative neuropsychological assessments from the Wechsler Adult Intelligence Scale–Third Edition (WAIS-III) and Wechsler Memory Scale–Revised (WMS-R), significant improvement following awake surgery was observed in mean Perceptual Organization (Z = −2.09, p = 0.04) in WAIS-III scores. Postoperative mean WMS-R scores for Visual Memory (Z = −2.12, p = 0.03) and Delayed Recall (Z = −1.98, p = 0.04) were significantly improved compared with preoperative values for every test after awake surgery. No significant deterioration was noted with regard to neurocognitive functions in a comprehensive neuropsychological test battery. In the postoperative course, early transient speech and motor disturbances were observed in 30.0% and 28.0% of patients, respectively. In contrast, late permanent speech and motor disturbances were observed in 0% and 4.0%, respectively.CONCLUSIONSIt is noteworthy that no significant postoperative deterioration was identified compared with preoperative status in a comprehensive neuropsychological assessment. The results demonstrated that awake functional mapping enabled favorable neurocognitive and functional outcomes after surgery in patients with diffuse frontal LGGs.

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