scholarly journals THE PATHOGENESIS OF SUBACUTE COMBINED DEGENERATION OF THE SPINAL CORD, WITH SPECIAL REFERENCE TO ITS CONNECTION WITH ADDISON'S (PERNICIOUS) ANÆMIA ACHLORHYDRIA AND INTESTINAL INFECTION

Brain ◽  
1922 ◽  
Vol 45 (2) ◽  
pp. 266-281 ◽  
Author(s):  
A. F. HURST ◽  
J. R. BELL
Keyword(s):  
Spinal Cord ◽  
Special Reference ◽  
Pernicious Anaemia ◽  
Intestinal Infection ◽  
Subacute Combined Degeneration

scholarly journals Helicobacter pylori associated vitamin B12 deficiency, pernicious anaemia and subacute combined degeneration of the spinal cord

2013 ◽  
Vol 2013 (sep29 1) ◽  
pp. bcr2013200380-bcr2013200380 ◽  
Author(s):  
H. B. Gowdappa ◽  
M. Mahesh ◽  
K. V. K. S. N. Murthy ◽  
M. G. Narahari
Keyword(s):  
Spinal Cord ◽  
Helicobacter Pylori ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Pernicious Anaemia ◽  
Subacute Combined Degeneration ◽  
B12 Deficiency

Autoimmune gastritis concomitant with gastric adenoma and subacute combined degeneration of the spinal cord

2021 ◽  
Vol 14 (5) ◽  
pp. e242836
Author(s):  
Masahiro Taniguchi ◽  
Gota Sudo ◽  
Yuzufumi Sekiguchi ◽  
Hiroshi Nakase
Keyword(s):  
Spinal Cord ◽  
Histopathological Examination ◽  
Intrinsic Factor ◽  
Pernicious Anaemia ◽  
Autoimmune Gastritis ◽  
Gastric Neoplasms ◽  
Gastric Body ◽  
Vitamin B ◽  
Gastric Adenoma ◽  
Subacute Combined Degeneration

A 62-year-old woman was referred to our department for further investigation of anaemia. Blood test showed macrocytic anaemia. Oesophagogastroduodenoscopy (OGD) revealed proximal-predominant gastric atrophy and flat elevated lesion in the gastric body. Several days after OGD, she complained of gait disturbance and was diagnosed with subacute combined degeneration of the spinal cord. Furthermore, laboratory tests showed positive for both anti-parietal cell and anti-intrinsic factor antibodies, as well as increased serum gastrin level and decreased pepsinogen I level, which confirmed the diagnosis of autoimmune gastritis (AIG). Anaemia and neurological symptoms were improved after vitamin B12 supplementation. Subsequently, the patient underwent gastric endoscopic submucosal dissection; histopathological examination revealed gastric adenoma. AIG can cause gastric neoplasms and vitamin B12 deficiency, with the latter resulting in pernicious anaemia and neurological disorders. These diseases are treatable but potentially life-threatening. This case highlights the importance of early diagnosis of AIG and proper management of its comorbidities.

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