Both primary motor cortex and supplementary motor area play an important role in complex finger movement

Brain ◽  
1993 ◽  
Vol 116 (6) ◽  
pp. 1387-1398 ◽  
Author(s):  
H. Shibasaki ◽  
N. Sadato ◽  
H. Lyshkow ◽  
Y. Yonekura ◽  
M. Honda ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Supplementary Motor Area ◽  
Motor Area ◽  
Finger Movement

scholarly journals Motor cortex activation in hemiparetic stroke patients

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 334-334
Author(s):  
Steven C Cramer ◽  
Keith C Stegbauer ◽  
Angela Mark ◽  
Robert Price ◽  
Kristin Barquist ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Corticospinal Tract ◽  
Supplementary Motor Area ◽  
Index Finger ◽  
Motor Area ◽  
Finger Movement ◽  
Post Stroke ◽  
Paretic Limb ◽  
Hemiparetic Stroke

100 Little is known about the function of surviving motor cortex after hemiparetic stroke. Though the corticospinal tract may be damaged, function may persist via intact intracortical connections. We probed motor cortex function using paradigms unrelated to genesis of paretic limb movement. Seven patients with chronic post-stroke hemiparesis, including total hand plegia, were studied with functional MRI (fMRI). Brain activation was achieved by alternating between rest and one of several stimuli. For the plegic hand, stimuli were passive index finger movement, or viewing active movements; for the non-plegic hand, active or passive index finger movement. Brain activation maps (p<.001) were generated, after which anatomical landmarks were used to identify regions of interest within non-infarcted tissue. Tasks were rehearsed before fMRI, during which surface EMG leads were placed on 5 muscles in each arm. Patients were median 5 months post-stroke, median age 66 years. Median NIH stroke scale score was 9; Rankin, 3; and arm motor Fugl-Meyer score, 18 (normal=66); Motor Activity Log confirmed no plegic hand use. Studies with excess head movement were excluded, including all plegic hand tasks for 1 patient. Plegic hand tasks (10 studies across 6 patients) activated the stroke hemisphere in all patients, including primary motor cortex (5 patients), primary sensory cortex (5 patients), premotor cortex (4 patients), and supplementary motor area (3 patients). Non-stroke hemisphere was also activated, particularly primary motor cortex (5 patients). In a few instances, EMG disclosed paretic arm muscle activity, but this had no relationship to fMRI activation. Non-plegic hand tasks (9 studies across 7 patients) activated the stroke hemisphere ipsilaterally, including supplementary motor area in all 7 patients, and primary motor cortex in 6 patients. In patients with post-stroke hemiparesis, passive stimulation activates surviving motor cortex regions within the stroke-affected hemisphere. After corticospinal tract damage, motor cortex can still be activated during tasks unrelated to paretic limb movement. The results may suggest therapeutic avenues for improving motor function after stroke.

Corticospinal Tract Microstructure Correlates With Beta Oscillatory Activity in the Primary Motor Cortex After Stroke

Stroke ◽  
2021 ◽  
Author(s):  
Robert Schulz ◽  
Marlene Bönstrup ◽  
Stephanie Guder ◽  
Jingchun Liu ◽  
Benedikt Frey ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Fractional Anisotropy ◽  
Primary Motor Cortex ◽  
Supplementary Motor Area ◽  
Premotor Cortex ◽  
Motor Impairment ◽  
Motor Area ◽  
Oscillatory Activity ◽  
Premotor Area ◽  
Beta Power

Background and Purpose: Cortical beta oscillations are reported to serve as robust measures of the integrity of the human motor system. Their alterations after stroke, such as reduced movement-related beta desynchronization in the primary motor cortex, have been repeatedly related to the level of impairment. However, there is only little data whether such measures of brain function might directly relate to structural brain changes after stroke. Methods: This multimodal study investigated 18 well-recovered patients with stroke (mean age 65 years, 12 males) by means of task-related EEG and diffusion-weighted structural MRI 3 months after stroke. Beta power at rest and movement-related beta desynchronization was assessed in 3 key motor areas of the ipsilesional hemisphere that are the primary motor cortex (M1), the ventral premotor area and the supplementary motor area. Template trajectories of corticospinal tracts (CST) originating from M1, premotor cortex, and supplementary motor area were used to quantify the microstructural state of CST subcomponents. Linear mixed-effects analyses were used to relate tract-related mean fractional anisotropy to EEG measures. Results: In the present cohort, we detected statistically significant reductions in ipsilesional CST fractional anisotropy but no alterations in EEG measures when compared with healthy controls. However, in patients with stroke, there was a significant association between both beta power at rest ( P =0.002) and movement-related beta desynchronization ( P =0.003) in M1 and fractional anisotropy of the CST specifically originating from M1. Similar structure-function relationships were neither evident for ventral premotor area and supplementary motor area, particularly with respect to their CST subcomponents originating from premotor cortex and supplementary motor area, in patients with stroke nor in controls. Conclusions: These data suggest there might be a link connecting microstructure of the CST originating from M1 pyramidal neurons and beta oscillatory activity, measures which have already been related to motor impairment in patients with stroke by previous reports.

Comparison of Neural Activity in the Supplementary Motor Area and in the Primary Motor Cortex in Monkeys

1991 ◽  
Vol 8 (1) ◽  
pp. 27-44 ◽  
Author(s):  
Chen Dao-fen ◽  
B. Hyland ◽  
V. Maier ◽  
A. Palmeri ◽  
M. Wiesendanger
Keyword(s):  
Motor Cortex ◽  
Neural Activity ◽  
Primary Motor Cortex ◽  
Supplementary Motor Area ◽  
Motor Area

scholarly journals The BOLD response in primary motor cortex and supplementary motor area during kinesthetic motor imagery based graded fMRI neurofeedback

NeuroImage ◽  
2019 ◽  
Vol 184 ◽  
pp. 36-44 ◽  
Author(s):  
David M.A. Mehler ◽  
Angharad N. Williams ◽  
Florian Krause ◽  
Michael Lührs ◽  
Richard G. Wise ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Motor Imagery ◽  
Primary Motor Cortex ◽  
Supplementary Motor Area ◽  
Motor Area ◽  
Bold Response
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