WHITE MATTER LESIONS ON MAGNETIC RESONANCE IMAGING IN CLINICALLY DIAGNOSED ALZHEIMER'S DISEASE: EVIDENCE FOR HETEROGENEITY

Brain ◽  
1992 ◽  
Vol 115 (3) ◽  
pp. 735-748 ◽  
Author(s):  
PH. SCHELTENS ◽  
F. BARKHOF ◽  
J. VALK ◽  
P. R. ALGRA ◽  
R. GERRITSEN VAN DER HOOP ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Lesions ◽  
Resonance Imaging

scholarly journals O4-09-04: Association of magnetic resonance imaging white matter lesions and cognitive decline in Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P701-P701
Author(s):  
Margit Mikula ◽  
Petroula Proitsi ◽  
Martina Sattlecker ◽  
Mike O'Sullivan ◽  
Andy Simmons ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Magnetic Resonance ◽  
Cognitive Decline ◽  
White Matter Lesions ◽  
Resonance Imaging

A Magnetic Resonance Imaging Study of White Matter Lesions in Depression and Alzheimer's Disease

1996 ◽  
Vol 168 (4) ◽  
pp. 477-485 ◽  
Author(s):  
John O'brien ◽  
Patricia Desmond ◽  
David Ames ◽  
Isaac Schweitzer ◽  
Susan Harrigan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Magnetic Resonance ◽  
Imaging Study ◽  
White Matter Lesions ◽  
Elderly Subjects ◽  
Resonance Imaging ◽  
Mri Scans

BackgroundWhite matter changes, as revealed by magnetic resonance imaging (MRI), may occur in depression and Alzheimer's disease.MethodT2-weighted MRI scans were performed in 39 control subjects, 61 subjects with NINCDS/ADRDA Alzheimer's disease and 60 subjects with DSM–III–R major depression. Deep white matter lesions (DWML) and periventricular lesions (PVL) were rated on a standard 0–3 scale by two radiologists blind to clinical diagnosis.ResultsAfter controlling for differences in vascular risk factors and current blood pressure, DWML were significantly more common in depressed subjects and PVL in Alzheimer's disease subjects compared to controls. DWML were most common in those presenting in late life with their first ever depression and 50% of such subjects had severe (grade 3) DWML.ConclusionAn association between DWML and depression and PVL and Alzheimer's disease is supported. The increase with DWML that occurs with ageing may predispose some elderly subjects to depression.

White matter magnetic resonance imaging hyperintensity in Alzheimer's disease: correlations with corpus callosum atrophy

1996 ◽  
Vol 243 (3) ◽  
pp. 231-234 ◽  
Author(s):  
Patrick Vermersch ◽  
Jean Roche ◽  
Mich�le Hamon ◽  
Christine Daems-Monpeurt ◽  
Jean-Pierre Pruvo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Magnetic Resonance ◽  
Corpus Callosum ◽  
Resonance Imaging

scholarly journals Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Wha Jin Lee ◽  
Cindy W. Yoon ◽  
Sung-Woo Kim ◽  
Hye Jin Jeong ◽  
Seongho Seo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Hyperintensities ◽  
Late Onset ◽  
Structural Connectivity ◽  
Resonance Imaging ◽  
White Matter Connectivity

Early- and late-onset Alzheimer’s disease (AD) patients often exhibit distinct features. We sought to compare overall white matter connectivity and evaluate the pathological factors (amyloid, tau, and vascular pathologies) that affect the disruption of connectivity in these two groups. A total of 50 early- and 38 late-onset AD patients, as well as age-matched cognitively normal participants, were enrolled and underwent diffusion-weighted magnetic resonance imaging to construct fractional anisotropy-weighted white matter connectivity maps. [18F]-THK5351 PET, [18F]-Flutemetamol PET, and magnetic resonance imaging were used for the evaluation of tau and related astrogliosis, amyloid, and small vessel disease markers (lacunes and white matter hyperintensities). Cluster-based statistics was performed for connectivity comparisons and correlation analysis between connectivity disruption and the pathological markers. Both patient groups exhibited significantly disrupted connectivity compared to their control counterparts with distinct patterns. Only THK retention was related to connectivity disruption in early-onset AD patients, and this disruption showed correlations with most cognitive scores, while late-onset AD patients had disrupted connectivity correlated with amyloid deposition, white matter hyperintensities, and lacunes in which only a few cognitive scores showed associations. These findings suggest that the pathogenesis of connectivity disruption and its effects on cognition are distinct between EOAD and LOAD.

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