MORPHOLOGICAL CHANGES IN UNMYELINATED NERVE FIBRES IN THE SURAL NERVE WITH AGE

Brain ◽  
1991 ◽  
Vol 114 (1) ◽  
pp. 585-599 ◽  
Author(s):  
TAKASHI KANDA ◽  
HIROSHI TSUKAGOSHI ◽  
MASAYA ODA ◽  
KAZUHITO MIYAMOTO ◽  
HITOSHI TANABE
Keyword(s):  
Sural Nerve ◽  
Morphological Changes ◽  
Nerve Fibres ◽  
Unmyelinated Nerve

Prolonged injury discharge in unmyelinated nerve fibres following transection of the sural nerve in rats

1996 ◽  
Vol 215 (3) ◽  
pp. 185-188 ◽  
Author(s):  
K.-H. Blenk ◽  
W. Jänig ◽  
M. Michaelis ◽  
C. Vogel
Keyword(s):  
Sural Nerve ◽  
Nerve Fibres ◽  
Unmyelinated Nerve

scholarly journals A Novel Model of Cancer-Induced Peripheral Neuropathy and the Role of TRPA1 in Pain Transduction

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Ahmad Maqboul ◽  
Bakheet Elsadek
Keyword(s):  
Immune Cells ◽  
Peripheral Nerves ◽  
Morphological Changes ◽  
Nerve Fibres ◽  
Cold Allodynia ◽  
Sciatic Nerves ◽  
Pain Transduction ◽  
Thermal Stimuli ◽  
Novel Model

Background. Models of cancer-induced neuropathy are designed by injecting cancer cells near the peripheral nerves. The interference of tissue-resident immune cells does not allow a direct contact with nerve fibres which affects the tumor microenvironment and the invasion process. Methods. Anaplastic tumor-1 (AT-1) cells were inoculated within the sciatic nerves (SNs) of male Copenhagen rats. Lumbar dorsal root ganglia (DRGs) and the SNs were collected on days 3, 7, 14, and 21. SN tissues were examined for morphological changes and DRG tissues for immunofluorescence, electrophoretic tendency, and mRNA quantification. Hypersensitivities to cold, mechanical, and thermal stimuli were determined. HC-030031, a selective TRPA1 antagonist, was used to treat cold allodynia. Results. Nociception thresholds were identified on day 6. Immunofluorescent micrographs showed overexpression of TRPA1 on days 7 and 14 and of CGRP on day 14 until day 21. Both TRPA1 and CGRP were coexpressed on the same cells. Immunoblots exhibited an increase in TRPA1 expression on day 14. TRPA1 mRNA underwent an increase on day 7 (normalized to 18S). Injection of HC-030031 transiently reversed the cold allodynia. Conclusion. A novel and a promising model of cancer-induced neuropathy was established, and the role of TRPA1 and CGRP in pain transduction was examined.

scholarly journals Characterisation of Morphology in Musculus Semitendinosus Tendon Used for Anterior Cruciate Ligament Reconstruction: A Pilot Study

2020 ◽  
Vol 18 (1) ◽  
pp. 1-6
Author(s):  
Janis Davis Osipovs ◽  
Mara Pilmane ◽  
Modris Ciems
Keyword(s):  
Anterior Cruciate Ligament ◽  
Morphological Changes ◽  
Cruciate Ligament ◽  
Collagen I ◽  
Collagen Fibres ◽  
Nerve Fibres ◽  
Tissue Ischemia ◽  
Moderate Number ◽  
Collagen Iii ◽  
Anterior Cruciate

SummaryIntroductionAnterior cruciate ligament (ACL) rupture is very common in athletes. In the general population, incidence is approximately 33 per 100 000 people.Aim of the studyThe aim of the study was the evaluation of morphological changes in the musculus semitendinosus tendon used for the reconstruction of ACL to understand the quality of most common for surgery used material.Material and methodsThe materials were obtained from four ACL autologous hamstring reconstruction surgeries. The tissue was stained with hematoxyllin and eosin and with immunohistochemical (IMH) staining of PGP9.5, VEGF, collagen I and collagen III. The material was evaluated with semiquantitative method.ResultsRoutine staining showed practically unchanged tendon structure, with one exception when sclerotic blood vessels were observed in endotenon. Collagen III IMH demonstrated moderate to numerous positive collagen fibres in two cases, but in other two there were only few positive structures seen. Collagen I IMH showed few to moderate number of positive collagen fibres in all cases. In two cases, moderate number of PGP9.5 positive nerve fibres was observed and in two other cases occasional to few number of positive structures was detected. PGP 9.5 marked higher number of nerve fibres in peritenon than in endotenon. Numerous VEGF positive endotheliocytes were observed in two cases, but in two other cases VEGF positive endotheliocytes were occasional.ConclusionsTendon of musculus semitendinosus displays two patterns of distribution of tissue ischemia, neuropeptide containing innervation and collagen I and III. Collagen III is thought to be evaluated as a response of tendon to the ischemia and intensive innervation, while increase of collagen I probably is related to the relatively unchanged vascularity and innervation. The pattern of musculus semitendinosus tendon structural changes seems to be connected to the individual homeostasis in patients persisting before the usage of tendon for the reconstruction.

Endometriotic lesions

2019 ◽  
Vol 11 (2) ◽  
pp. 62-76
Author(s):  
Sri PK Maharajaa ◽  
Razan Asally ◽  
Robert Markham ◽  
Frank Manconi
Keyword(s):  
Immune Cell ◽  
Histopathological Examination ◽  
Abdominal Cavity ◽  
Reproductive Age ◽  
Deep Infiltrating Endometriosis ◽  
Therapeutic Approaches ◽  
Nerve Fibres ◽  
Pain Mechanisms ◽  
Unmyelinated Nerve

Endometriosis is a complex gynaecological condition affecting women of reproductive age. It is characterised by the presence of lesions containing endometrial glands and stroma outside the uterus. The disease is typically associated with pelvic pain (including dysmenorrhoea and dyspareunia), infertility and bowel-related symptoms. Endometriotic lesions have a highly variable presentation and most commonly occur in the abdominal cavity. These lesions are broadly classified into peritoneal, ovarian and deep infiltrating endometriosis. There have been observations of increased density of nerve fibres and neurological molecules in the endometriotic lesions compared to the uninvolved peritoneum of women without endometriosis and the presence of unmyelinated nerve fibres were higher near the glands. The lesion sites are characterised by a range of immunological alterations, and specific immune cell populations have also been known to synthesise and secrete neurogenic factors. Endometriotic lesions are capable of producing prostaglandins which are direct generators of pain and are capable of inducing inflammation. Diagnosing the disease involves direct visualisation of the lesions through a laparoscopic or laparotomy, which is followed by histopathological examination of biopsied or excised lesions. The staging of endometriosis due to its complexity is highly variable as presentation and gaps in knowledge pose a great challenge in the classification of the disease. The medical management of endometriosis aims at providing adequate analgesia and suppression of the activity of the lesion. A better understanding of endometriotic lesion relationships between innervations and specific clinical characteristics may elucidate aspects of pain mechanisms and infertility in endometriosis and facilitate the development of novel therapeutic approaches.

The Unmyelinated Nerve Fibres of the Cochlea

1976 ◽  
Vol 82 (1-6) ◽  
pp. 157-164 ◽  
Author(s):  
A. Paradiesgarten ◽  
H. Spoendlin
Keyword(s):  
Nerve Fibres ◽  
Unmyelinated Nerve

scholarly journals Simultaneous Quantification of Unmyelinated Nerve Fibers in Sural Nerve and in Skin

2015 ◽  
Vol 75 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Mathilde Duchesne ◽  
Laurent Magy ◽  
Laurence Richard ◽  
Pierre Ingrand ◽  
Jean-Philippe Neau ◽  
...  
Keyword(s):  
Sural Nerve ◽  
Nerve Fibers ◽  
Simultaneous Quantification ◽  
Unmyelinated Nerve
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