scholarly journals Stem cell-based therapy and regenerative approaches to diseases of the respiratory system

2011 ◽  
Vol 99 (1) ◽  
pp. 169-187 ◽  
Author(s):  
P. Jungebluth ◽  
P. Macchiarini
Keyword(s):  
Stem Cell ◽  
Respiratory System ◽  
Cell Based Therapy

Addressing the importance of Stem cell-based therapy: a Perspective in the treatment of COVID-19’

2020 ◽  
Vol 20 ◽  
Author(s):  
Christine Ibrahim ◽  
Hanna Semaan ◽  
Marwan El-Sabban ◽  
Fadia Najjar ◽  
Aline Hamade
Keyword(s):  
Stem Cell ◽  
Drug Repositioning ◽  
World Health ◽  
Unknown Etiology ◽  
Cell Based Therapy ◽  
Pathogenic Virus ◽  
Lung Injuries ◽  
Healthcare Crisis ◽  
Health Organization ◽  
Potential Use

: Severe acute respiratory syndrome-associated corona virus 2 (SARS-CoV-2), is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO) pointing to the over 118000 cases of Coronavirus disease 2019 (COVID- 19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview on the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.

An Update on Human Stem Cell-Based Therapy in Parkinson';s Disease

2016 ◽  
Vol 11 (7) ◽  
pp. 561-568 ◽  
Author(s):  
Clara González ◽  
Sonia Bonilla ◽  
Ana Isabel Flores ◽  
Eva Cano ◽  
Isabel Liste
Keyword(s):  
Stem Cell ◽  
Human Stem Cell ◽  
Cell Based Therapy

Mesenchymal stem cell-based therapy for nonhealing wounds: today and tomorrow

2015 ◽  
Vol 23 (4) ◽  
pp. 465-482 ◽  
Author(s):  
Meirong Li ◽  
Yali Zhao ◽  
Haojie Hao ◽  
Weidong Han ◽  
Xiaobing Fu
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Based Therapy

scholarly journals Preclinical efficacy of stem cell therapy for skin flap: a systematic review and meta-analysis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yuan Li ◽  
Qi-lin Jiang ◽  
Leanne Van der Merwe ◽  
Dong-hao Lou ◽  
Cai Lin
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Survival Rate ◽  
Meta Analysis ◽  
Skin Flap ◽  
Cochrane Library ◽  
Skin Flaps ◽  
Cell Based Therapy ◽  
Stem Cell Treatment

Abstract Background A skin flap is one of the most critical surgical techniques for the restoration of cutaneous defects. However, the distal necrosis of the skin flap severely restricts the clinical application of flap surgery. As there is no consensus on the treatment methods to prevent distal necrosis of skin flaps, more effective and feasible interventions to prevent skin flaps from necrosis are urgently needed. Stem therapy as a potential method to improve the survival rate of skin flaps is receiving increasing attention. Methods This review followed the recommendations from the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statements. Twenty studies with 500 animals were included by searching Web of Science, EMBASE, PubMed, and Cochrane Library databases, up until October 8, 2020. Moreover, the references of the included articles were searched manually to obtain other studies. All analyses were conducted using Review Manager V.5.3 software. Results Meta-analysis of all 20 studies demonstrated stem cell treatment has significant effects on reducing necrosis of skin flap compared with the control group (SMD: 3.20, 95% CI 2.47 to 3.93). Besides, subgroup analysis showed differences in the efficacy of stem cells in improving the survival rate of skin flaps in areas of skin flap, cell type, transplant types, and method of administration of stem cells. The meta-analysis also showed that stem cell treatment had a significant effect on increasing blood vessel density (SMD: 2.96, 95% CI 2.21 to 3.72) and increasing the expression of vascular endothelial growth factor (VEGF, SMD: 4.34, 95% CI 2.48 to 6.1). Conclusions The preclinical evidence of our systematic review indicate that stem cell-based therapy is effective for promoting early angiogenesis by up regulating VEGF and ultimately improving the survival rate of skin flap. In summary, small area skin flap, the administration method of intra-arterial injection, ASCs and MSCs, and xenogenic stem cells from humans showed more effective for the survival of animal skin flaps. In general, stem cell-based therapy may be a promising method to prevent skin flap necrosis.

Current Perspectives Regarding Stem Cell-based Therapy for Ischemic Stroke

2018 ◽  
Vol 24 (28) ◽  
pp. 3332-3340 ◽  
Author(s):  
Kyeong-Ah Kwak ◽  
Ho-Beom Kwon ◽  
Joo Won Lee ◽  
Young-Seok Park
Keyword(s):  
Clinical Trials ◽  
Stem Cell ◽  
Ischemic Stroke ◽  
Time Window ◽  
Experimental Studies ◽  
Cell Type ◽  
Stroke Treatment ◽  
Cell Based Therapy ◽  
Regenerative Approach ◽  
Therapeutic Time Window

Stroke is a leading cause of death and disability worldwide. Conventional treatment has a limitation of very narrow therapeutic time window and its devastating nature necessitate a novel regenerative approach. Transplanted stem cells resulted in functional recovery through multiple mechanisms including neuroprotection, neurogenesis, angiogenesis, immunomodulation, and anti-inflammatory effects. Despite the promising features shown in experimental studies, results from clinical trials are inconclusive from the perspective of efficacy. The present review presents a synopsis of stem cell research on ischemic stroke treatment according to cell type. Clinical trials to the present are briefly summarized. Finally, the hurdles and issues to be solved are discussed for clinical application.

scholarly journals Autologous stem cell transplantation in refractory Asherman′s syndrome: A novel cell based therapy

2014 ◽  
Vol 7 (2) ◽  
pp. 93 ◽  
Author(s):  
Neeta Singh ◽  
Sujata Mohanty ◽  
Tulika Seth ◽  
Meenakshi Shankar ◽  
Sona Dharmendra ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Cell Based Therapy
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