scholarly journals Cardiac radionuclide imaging in stable coronary artery disease and acute coronary syndromes

2008 ◽  
Vol 89 (1) ◽  
pp. 63-78 ◽  
Author(s):  
J. Stirrup ◽  
K. Wechalekar ◽  
A. Maenhout ◽  
C. Anagnostopoulos
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Radionuclide Imaging ◽  
Acute Coronary Syndromes ◽  
Stable Coronary Artery Disease ◽  
Coronary Syndromes ◽  
Artery Disease

Abstract 1521: Platelet RNA Content is Increased in Patients with Acute Coronary Syndromes Compared to Patients with stable Coronary Artery Disease and Healthy Individuals

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Erik L Grove ◽  
Anne-Mette Hvas ◽  
Steen D Kristensen
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Acute Coronary Syndromes ◽  
Thrombus Formation ◽  
Stable Coronary Artery Disease ◽  
Healthy Individuals ◽  
Coronary Thrombus ◽  
Coronary Syndromes ◽  
Immature Platelets ◽  
Artery Disease

Background: Platelets newly released from the bone marrow are characterized by large cell volumes and, contrary to mature platelets, contain RNA, which might reflect an increased capacity of producing proaggregatory proteins. We hypothesized that the fraction of RNA-containing, immature platelets (Immature Platelet Fraction = IPF) is a marker for acute coronary thrombus formation. Methods: Flow cytometric determination of immature platelets was conducted using a RNA fluorescent dye and an automated analyzer (Sysmex XE-2100). Measurements were performed in a total of 426 individuals (365 patients with acute coronary syndromes (ACS), 39 patients with stable coronary artery disease (CAD) and 22 healthy individuals). Results: Geometric mean IPF was 2.5 (CV = 0.37) in the control group, 2.9 (0.43) in patients with stable CAD, 3.0 (0.55) in the non-STEMI/Unstable Angina group and 3.7 (0.56) in patients with STEMI. IPF was significantly increased in STEMI patients compared to all other groups (t-test for log-transformed data: p < 0.004), and the overall difference between groups was significant (ANOVA: p < 0.0001). IPF was increased in active smokers among patients with ACS (3.2 vs 3.6, p=0.02), whereas no relation with age, sex, body mass index or CRP levels was observed. Conclusion: The fraction of RNA-containing platelets is increased in ACS, especially in the acute phase of STEMI. Immature platelets with an increased haemostatic potential may contribute to coronary thrombus formation and may partly explain previous findings of temporary resistance to anti-platelet therapy.

scholarly journals Oxidized LDL and Malondialdehyde-Modified LDL in Patients With Acute Coronary Syndromes and Stable Coronary Artery Disease

Circulation ◽  
1998 ◽  
Vol 98 (15) ◽  
pp. 1487-1494 ◽  
Author(s):  
Paul Holvoet ◽  
Johan Vanhaecke ◽  
Stefaan Janssens ◽  
Frans Van de Werf ◽  
Désiré Collen
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Acute Coronary Syndromes ◽  
Oxidized Ldl ◽  
Stable Coronary Artery Disease ◽  
Modified Ldl ◽  
Coronary Syndromes ◽  
Artery Disease
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