scholarly journals Corrigendum to: Center volume impact on graft survival and waitlist time in donation after circulatory death (DCD) liver transplantation in the United States

2021 ◽  
Author(s):  
Emmanouil Giorgakis ◽  
Shirin E Khorsandi ◽  
Lyle Burdine ◽  
Andrew Singer ◽  
Winston Hewitt ◽  
...  
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Graft Survival ◽  
The United States ◽  
Donation After Circulatory Death ◽  
Center Volume ◽  
Circulatory Death

Donation after Circulatory Death: Potential Mechanisms of Injury and Preventative Strategies

2020 ◽  
Vol 40 (03) ◽  
pp. 256-263
Author(s):  
Kristopher P. Croome
Keyword(s):  
Liver Transplantation ◽  
Clinical Practice ◽  
Learning Curve ◽  
Graft Survival ◽  
Biliary Complications ◽  
Donation After Circulatory Death ◽  
Concise Review ◽  
Number Of Patients ◽  
Circulatory Death

AbstractDonation after circulatory death (DCD) donors represent a potential means to help address the disparity between the number of patients awaiting liver transplantation (LT) and the availability of donor livers. While initial enthusiasm for DCD LT was high in the early 2000s, early reports of high rates of biliary complications and inferior graft survival resulted in reluctance among many transplant centers to use DCD liver grafts. As with all innovations in transplant practice, there is undoubtedly a learning curve associated with the optimal utilization of liver grafts from DCD donors. More contemporary data has demonstrated that results with DCD LT are improving and the number of DCD LT performed annually has been steadily increasing. In this concise review, potential mechanisms of injury for DCD livers are discussed along with strategies that have been employed in clinical practice to improve DCD LT outcomes.

Both Alcoholic and Nonalcoholic Steatohepatitis Is an Emerging Indication for Liver Transplantation in the United States

2020 ◽  
Vol 04 (02) ◽  
pp. 223-234
Author(s):  
Danielle Fritze ◽  
Amandeep Singh ◽  
Eric Lawitz ◽  
Kris V. Kowdley ◽  
Glenn Halff ◽  
...  
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Nonalcoholic Steatohepatitis ◽  
Multivariable Analysis ◽  
Deceased Donor ◽  
The United States ◽  
Hispanic Males ◽  
Patient And Graft Survival ◽  
United Network

Abstract Background Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease (ALD) are now the most common indications for liver transplantation (LT) in the United States. A subset of patients have both alcoholic and nonalcoholic steatohepatitis (BASH). This study characterizes patients with BASH requiring LT and assesses changes in the prevalence of BASH as an indication for LT. Methods The United Network for Organ Sharing database was analyzed for all patients ≥ 18 years of age who received their first deceased donor LT from 2002 to 2016 for ALD, NASH, or BASH. Baseline demographics, clinical parameters, and LT outcomes were compared between groups. Results Since 2002, 85,448 patients underwent LT:15,327 had ALD, 9,971 had NASH, and 2,779 had BASH. The prevalence of BASH as an indication for LT increased from 0.5% in 2002 to 5% in 2016. Compared with patients with NASH, those with BASH were significantly more likely to be male (85.6 vs. 57%), younger (mean 56.4 vs. 58.6 years), and Hispanic (22.2 vs. 13.6%) (p < 0.001 for all). While indication for transplant was not significantly associated with transplant outcomes on multivariable analysis, patient and graft survival curves do differ significantly by indication for transplant, with worse outcomes for patients with BASH (patient survival at 5 years: NASH 78.1%, ALD 77.2%, BASH 73.5%, p = 0.013; graft survival at 5 years: NASH 75.3%, ALD 74.0%, BASH 70.8%, p = 0.046). Conclusions BASH is a rising indication for LT, especially for Hispanic males, due to the increasing prevalence of ALD and NASH in the United States.

scholarly journals Role of donor hemodynamic trajectory in determining graft survival in liver transplantation from donation after circulatory death donors

2016 ◽  
Vol 22 (11) ◽  
pp. 1469-1481 ◽  
Author(s):  
Daniel J. Firl ◽  
Koji Hashimoto ◽  
Colin O'Rourke ◽  
Teresa Diago-Uso ◽  
Masato Fujiki ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Immunosuppression in Donation After Circulatory Death Liver Transplantation: Can Induction Modify Graft Survival?

2020 ◽  
Vol 26 (9) ◽  
pp. 1154-1166
Author(s):  
Kevin Ig‐Izevbekhai ◽  
David S. Goldberg ◽  
Seth J. Karp ◽  
David P. Foley ◽  
Peter L. Abt
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Donation After Circulatory Death ◽  
Circulatory Death

scholarly journals United States donation after circulatory death liver transplantation is driven by a few high‐utilization transplant centers

2019 ◽  
Vol 20 (1) ◽  
pp. 320-321 ◽  
Author(s):  
Mark J. Hobeika ◽  
Terri Menser ◽  
Duc T. Nguyen ◽  
Lauren L. Beal ◽  
Stephanie Zajac ◽  
...  
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Donation After Circulatory Death ◽  
High Utilization ◽  
Circulatory Death
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