scholarly journals Author response to: Survival after antireflux surgery versus medication in patients with reflux oesophagitis or Barrett’s oesophagus: multinational cohort study

2021 ◽  
Author(s):  
Jesper Lagergren
Keyword(s):  
Cohort Study ◽  
Antireflux Surgery ◽  
Reflux Oesophagitis ◽  
Barrett’S Oesophagus ◽  
Author Response ◽  
Barrett's Oesophagus ◽  
Reflux Œsophagitis

415 OCCUPATIONAL PHYSICAL ACTIVITY AND THE RISK OF GORD, BARRETT’S OESOPHAGUS AND OESOPHAGEAL ADENOCARCINOMA A PROSPECTIVE COHORT STUDY IN UK BIOBANK

2020 ◽  
Vol 33 (Supplement_1) ◽  
Author(s):  
S Lam ◽  
G Savva ◽  
L Alexandre ◽  
B Kumar ◽  
A Hart
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Gastroesophageal Reflux Disease ◽  
Reflux Oesophagitis ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Occupational Physical Activity ◽  
Barrett's Oesophagus ◽  
Manual Activity ◽  
Reflux Œsophagitis

Abstract   Recreational physical activity has been shown to protect against the development of oesophageal adenocarcinoma as well as gastroesophageal reflux disease (GORD), but such effects have not been demonstrated for non-recreational activity. We examined whether high levels of occupational physical activity (heavy manual labour or physical work) were associated with the risk of oesophageal adenocarcinoma as well as its sequential precursor diseases; gastroesophageal reflux disease (GORD), reflux oesophagitis and Barrett’s oesophagus. Methods In this population-based prospective cohort study, participants aged between 37 to 73 years were recruited from 22 regions across the United Kingdom. Baseline occupational information of job type and levels of heavy manual activity was assessed using both questionnaires and verbal interviews. Incident cases were identified by linkage with routinely collected hospital inpatient and cancer registry data for England, Scotland and Wales. Primary clinical outcomes were GORD without oesophagitis, GORD with oesophagitis (reflux oesophagitis), Barrett’s oesophagus and oesophageal adenocarcinoma. The effects of heavy manual activity on disease risk were estimated using Cox proportional hazard regression. Results Between 2006 and 2010, 502 524 men and women were enrolled. Main analyses were limited to the working population with a full set of variables of interest (n = 266 453). Compared to jobs with low levels of heavy manual activity, high level jobs had increased hazard ratios (HRs) for GORD (1.20, 95% CI 1.11–1.30), reflux oesophagitis (1.17, 95% CI 1.04–1.31) and Barrett’s oesophagus (1.13, 95% CI 0.98–1.32), but not oesophageal adenocarcinoma (0.91 95% CI 0.54–1.56). Conclusion High levels of occupational heavy manual activity could be used as a risk factor for GORD and reflux oesophagitis, the precursor diseases of Barrett’s oesophagus and oesophageal adenocarcinoma.

scholarly journals Dietary inflammatory index and risk of reflux oesophagitis, Barrett’s oesophagus and oesophageal adenocarcinoma: a population-based case–control study

2017 ◽  
Vol 117 (9) ◽  
pp. 1323-1331 ◽  
Author(s):  
Nitin Shivappa ◽  
James R. Hebert ◽  
Lesley A. Anderson ◽  
Martha J. Shrubsole ◽  
Liam J. Murray ◽  
...  
Keyword(s):  
Reflux Oesophagitis ◽  
Cell Cancer ◽  
Acid Reflux ◽  
Population Based ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Dietary Inflammatory Index ◽  
Barrett's Oesophagus ◽  
Inflammatory Index ◽  
Reflux Œsophagitis

AbstractThe dietary inflammatory index (DIITM) is a novel composite score based on a range of nutrients and foods known to be associated with inflammation. DII scores have been linked to the risk of a number of cancers, including oesophageal squamous cell cancer and oesophageal adenocarcinoma (OAC). Given that OAC stems from acid reflux and that the oesophageal epithelium undergoes a metaplasia-dysplasia transition from the resulting inflammation, it is plausible that a high DII score (indicating a pro-inflammatory diet) may exacerbate risk of OAC and its precursor conditions. The aim of this analytical study was to explore the association between energy-adjusted dietary inflammatory index (E-DIITM) in relation to risk of reflux oesophagitis, Barrett’s oesophagus and OAC. Between 2002 and 2005, reflux oesophagitis (n219), Barrett’s oesophagus (n220) and OAC (n224) patients, and population-based controls (n256), were recruited to the Factors influencing the Barrett’s Adenocarcinoma Relationship study in Northern Ireland and the Republic of Ireland. E-DII scores were derived from a 101-item FFQ. Unconditional logistic regression analysis was applied to determine odds of oesophageal lesions according to E-DII intakes, adjusting for potential confounders. High E-DII scores were associated with borderline increase in odds of reflux oesophagitis (OR 1·87; 95 % CI 0·93, 3·73), and significantly increased odds of Barrett’s oesophagus (OR 2·05; 95 % CI 1·22, 3·47), and OAC (OR 2·29; 95 % CI 1·32, 3·96), when comparing the highest with the lowest tertiles of E-DII scores. In conclusion, a pro-inflammatory diet may exacerbate the risk of the inflammation-metaplasia-adenocarcinoma pathway in oesophageal carcinogenesis.

Oesophageal acid exposure: higher in Barrett's oesophagus than in reflux oesophagitis

1999 ◽  
Vol 31 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Jukka T Salminen ◽  
Juha A Tuominen ◽  
O. Juhani Rämö ◽  
Martti A Färkkilä ◽  
Jarmo A Salo
Keyword(s):  
Reflux Oesophagitis ◽  
Acid Exposure ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus ◽  
Reflux Œsophagitis

Microvascular lesions in reflux oesophagitis and Barrett's oesophagus

1994 ◽  
Vol 173 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Andrea Sbarbati ◽  
Francesco Ricci ◽  
Giorgio Inaspettato ◽  
Giuseppe Lazzara ◽  
Claudio Cordiano ◽  
...  
Keyword(s):  
Reflux Oesophagitis ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus ◽  
Reflux Œsophagitis

scholarly journals Vitamin D, calcium and dairy intake, and risk of oesophageal adenocarcinoma and its precursor conditions

2011 ◽  
Vol 106 (5) ◽  
pp. 732-741 ◽  
Author(s):  
Helen G. Mulholland ◽  
Liam J. Murray ◽  
Lesley A. Anderson ◽  
Marie M. Cantwell
Keyword(s):  
Vitamin D ◽  
Reflux Oesophagitis ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Dietary Vitamin ◽  
Barrett's Oesophagus ◽  
Dairy Intake ◽  
Vitamin D Intake ◽  
Increased Risk ◽  
Reflux Œsophagitis

Evidence is accumulating that vitamin D may be protective against carcinogenesis, although exceptions have been observed for some digestive tract neoplasms. The aim of the present study was to explore the association between dietary vitamin D and related nutrients and the risk of oesophageal adenocarcinoma and its precursor conditions, Barrett's oesophagus and reflux oesophagitis. In an all-Ireland case–control study conducted between March 2002 and July 2005, 218 oesophageal adenocarcinoma patients, 212 Barrett's oesophagus patients, 208 reflux oesophagitis patients and 252 population-based controls completed a 101-item FFQ, and provided lifestyle and demographic information. Multiple logistic regression analysis was applied to examine the association between dietary intake and disease risk. Oesophageal adenocarcinoma risk was significantly greater for individuals with the highest compared with the lowest tertile of vitamin D intake (OR 1·99, 95 % CI 1·03, 3·86;Pfor trend = 0·02). The direct association could not be attributed to a particular vitamin D food source. Vitamin D intake was unrelated to Barrett's oesophagus and reflux oesophagitis risk. No significant associations were observed for Ca or dairy intake and oesophageal adenocarcinoma, Barrett's oesophagus or reflux oesophagitis development. High vitamin D intake may increase oesophageal adenocarcinoma risk but is not related to reflux oesophagitis and Barrett's oesophagus. Ca and dairy product intake did not influence the development of these oesophageal lesions. These findings suggest that there may be population subgroups at an increased risk of oesophageal adenocarcinoma if advice to improve vitamin D intake from foods is implemented. Limited work has been conducted in this area, and further research is required.

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