scholarly journals Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

2017 ◽  
Vol 119 ◽  
pp. i167-i175 ◽  
Author(s):  
C.J. Weir ◽  
S.J. Mitchell ◽  
J.J. Lambert
Keyword(s):  
Gabaa Receptor ◽  
Receptor Subtypes ◽  
Behavioural Effects ◽  
Gabaa Receptor Subtypes

Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes

2006 ◽  
Vol 187 (3) ◽  
pp. 321-330 ◽  
Author(s):  
Angela N. Duke ◽  
Donna M. Platt ◽  
James M. Cook ◽  
Shengming Huang ◽  
Wenyuan Yin ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Squirrel Monkeys ◽  
Receptor Subtypes ◽  
Sucrose Pellet ◽  
Gabaa Receptor Subtypes

scholarly journals Cognition-impairing effects of benzodiazepine-type drugs: Role of GABAA receptor subtypes in an executive function task in rhesus monkeys

2013 ◽  
Vol 104 ◽  
pp. 62-68 ◽  
Author(s):  
Leah Makaron ◽  
Casey A. Moran ◽  
Ojas Namjoshi ◽  
Sundari Rallapalli ◽  
James M. Cook ◽  
...  
Keyword(s):  
Executive Function ◽  
Gabaa Receptor ◽  
Rhesus Monkeys ◽  
Receptor Subtypes ◽  
Gabaa Receptor Subtypes

Differentiating the role of γ-aminobutyric acid type A (GABAA) receptor subtypes

2004 ◽  
Vol 32 (3) ◽  
pp. 553-556 ◽  
Author(s):  
K.A. Wafford ◽  
A.J. Macaulay ◽  
R. Fradley ◽  
G.F. O'Meara ◽  
D.S. Reynolds ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Type A ◽  
Aminobutyric Acid ◽  
Receptor Subtype ◽  
Receptor Subtypes ◽  
Acid Type ◽  
Gabaa Receptor Subtypes ◽  
Subtype Selective

The inhibitory tone maintained throughout the central nervous system relies predominantly on the activity of neuronal GABAA (γ-aminobutyric acid type A) receptors. This receptor family comprises various subtypes that have unique regional distributions, but little is known about the role played by each subtype. The majority of the receptors contain a γ2 subunit and are sensitive to modulation by BZs (benzodiazepines), but differ with regard to α and β subunits. Mutagenesis studies combined with molecular modelling have enabled a greater understanding of receptor structure and dynamics. This can now be extended to in vivo activity through translation to genetically modified mice containing these mutations. Ideally, the mutation should leave normal receptor function intact, and this is the case with mutations affecting the BZ-binding site of the GABAA receptor. We have generated mutations, which affect the BZ site of different α subunits, to enable discrimination of the various behavioural consequences of BZ drug action. This has aided our understanding of the roles played by individual GABAA receptor subtypes in particular behaviours. We have also used this technique to explore the role of different β subunits in conferring the anaesthetic activity of etomidate. This technique together with the development of subtype-selective compounds facilitates our understanding of the roles played by each receptor subtype.

Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABAA receptor subtypes

2021 ◽  
Vol 228 ◽  
pp. 108985
Author(s):  
Angela N. Duke ◽  
V.V.N. Phani Babu Tiruveedhula ◽  
Dishary Sharmin ◽  
Daniel E. Knutson ◽  
James M. Cook ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Rhesus Monkeys ◽  
Receptor Subtypes ◽  
Gabaa Receptor Subtypes
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