scholarly journals Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database

2017 ◽  
Vol 119 (4) ◽  
pp. 626-636 ◽  
Author(s):  
M. Shankar-Hari ◽  
D.A. Harrison ◽  
G.D. Rubenfeld ◽  
K. Rowan
Keyword(s):  
Septic Shock ◽  
Critical Care ◽  
Critical Care Units ◽  
Sepsis And Septic Shock ◽  
Care Database

scholarly journals Sepsis Code: dodging mortality in a tertiary hospital

2021 ◽  
Author(s):  
Rosa Méndez ◽  
Angels Figuerola ◽  
Marta Chicot ◽  
Ana Barrios ◽  
Natalia Pascual ◽  
...  
Keyword(s):  
Septic Shock ◽  
Critical Care ◽  
Health Personnel ◽  
Analytical Study ◽  
Statistical Significance ◽  
Tertiary Hospital ◽  
Critical Care Units ◽  
Multidisciplinary Group ◽  
Sepsis And Septic Shock ◽  
The Impact

Background. In the hospital of La Princesa, the “Sepsis Code” (CSP) began in 2015, as a multidisciplinary group that provides health personnel with clinical, analytical and organizational tools, with the aim of the detection and early treatment of patients with sepsis. The objective of this study is to evaluate the impact of CSP implantation on mortality and to determine the variables associated with an increase in it. Material and methods. A retrospective analytical study of patients with CSP alert activation from 2015 to 2018 was conducted. Clinical-epidemiological variables, analytical parameters, and severity factors such as admission to critical care units (UCC) and the need for amines were collected. Statistical significance was established at p < 0.05. Results. We included 1,121 patients. The length of stay was 16 days and 32% required admission to UCC. Mortality showed a statistically significant linear downward trend from 24% in 2015 to 15% in 2018. The predictive mortality variables with statistically significant association were lactate > 2 mmol/L, creatinine > 1.6 mg/dL and the need for amines. Conclusions. The implementation of Sepsis Code decreases the mortality of patients with sepsis and septic shock. The presence of a lactate > 2 mmol/L, creatinine > 1.6 mg/dL and/or the need to administer amines in the first 24 hours, are associated with an increase in mortality in the patient with sepsis.

scholarly journals ADVANCED CRITICAL CARE TRANSTHORACIC ECHOCARDIOGRAPHY IN SEVERE SEPSIS AND SEPTIC SHOCK

CHEST Journal ◽  
2009 ◽  
Vol 136 (4) ◽  
pp. 128S
Author(s):  
Joel E. Pittman ◽  
Colin Grissom ◽  
Samuel Brown ◽  
Chad Cole ◽  
Ellie Hirshberg ◽  
...  
Keyword(s):  
Septic Shock ◽  
Critical Care ◽  
Severe Sepsis ◽  
Transthoracic Echocardiography ◽  
Sepsis And Septic Shock

scholarly journals Update on Changing Terminologies in Sepsis

2016 ◽  
Vol 36 (2) ◽  
pp. 178-183
Author(s):  
Ashish Kumar Simalti ◽  
Ranjit Ghuliani ◽  
Bindu T. Nair
Keyword(s):  
Septic Shock ◽  
Critical Care ◽  
Intensive Care ◽  
Intensive Care Medicine ◽  
European Society ◽  
Task Force ◽  
Critical Care Medicine ◽  
International Consensus ◽  
The Third ◽  
Sepsis And Septic Shock

Definitions of sepsis and septic shock were last revised in 2001. Since then there have been considerable advances in our understanding of pathophysiology, management, and epidemiology of sepsis, suggesting the need for reexamination. The European Society of Intensive Care Medicine and the Society of Critical Care Medicine convened a task force in January 2014 with objective to evaluate and, as needed, update definitions for sepsis and septic shock. Recommendations of this task force were published recently as “The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)”. The aim of this article is to generate awareness and discussion regarding this new important development.  

scholarly journals Early Lactate Clearance Rate is an Indicator of Outcome in Severe Sepsis and Septic Shock

2018 ◽  
Vol 8 (3) ◽  
pp. 223-228
Author(s):  
Rozina Sultana ◽  
Tarikul Hamid ◽  
ASM Areef Ahsan ◽  
Kaniz Fatema ◽  
Fatema Ahmed ◽  
...  
Keyword(s):  
Septic Shock ◽  
Critical Care ◽  
Severe Sepsis ◽  
Clearance Rate ◽  
Lactate Clearance ◽  
Serum Lactate ◽  
Critical Care Medicine ◽  
Co Morbidity ◽  
Sepsis And Septic Shock ◽  
Important Marker

Background: Lactate clearance is an important marker of global tissue hypoxia and might be used as an indicator of outcome in patients with severe sepsis and septic shock. This study was done to see the association between lactate clearance with the outcome of the patients of severe sepsis and septic shock among the patients who were admitted in the Department of Critical Care Medicine of BIRDEM General Hospital.Methods: This observational study was done in the Department of Critical Care Medicine, BIRDEM General Hospital from August 2015 to July 2016. At zero hour (during admission), first sample of serum lactate was sent and second sample after 6 hours of resuscitation for calculation of lactate clearance rate. Patients having lactate clearance e”10% were classified as high lactate clearance (HLC) and <10% were low lactate clearance (LLC).Results: Total 186 patients (male 96, female 90, mean age 63.07±14.17 years) with severe sepsis (80) and septic shock (106) were enrolled. Diabetes mellitus (DM) was the most common co morbidity (76.9%) and predominant diagnosis was pneumonia (90.3%). Among patients with septic shock, 51.9% (55/106) had LLC and 48.1% (51/106) had HLC. Among patients with severe sepsis, 28.8% (23/80) had LLC and 71.2% (57/80) had HLC. Among 57 patients of HLC group of severe sepsis, 73.6% (n= 42) were survivors and 26.3% (n=15) were non-survivor and 23 patients of LLC group of severe sepsis, 26.09% (n=6) were survivors and 73.91% (n=17) were-non survivors (p=<0.001). Among 51 patients of HLC group of septic shock, 78.43% (n=40) were survivors and 21.57% (n=11) were non-survivors and 55 patients of LLC group of septic shock, 29.09% (n=16) were survivors and 70.91% (n=39) were non-survivors (p=<0.001).Conclusion: Patients with HLC after 6 hours of management had better outcome than LLC.Birdem Med J 2018; 8(3): 223-228

Plasma Filtration Adsorption Dialysis (PFAD): A New Technology for Blood Purification

2005 ◽  
Vol 28 (7) ◽  
pp. 731-738 ◽  
Author(s):  
F. Nalesso
Keyword(s):  
Septic Shock ◽  
Critical Care ◽  
Severe Sepsis ◽  
Inflammatory Mediators ◽  
High Volume ◽  
Blood Purification ◽  
Plasma Filtration ◽  
High Volume Hemofiltration ◽  
Anti Inflammatory ◽  
Sepsis And Septic Shock

Severe sepsis is one of the most significant challenges in critical care. Despite all the developments achieved in infectious diseases and critical care, along with numerous attempts to develop treatments, the mortality rate of severe sepsis and septic shock remains unacceptably high. The pathophysiology of severe sepsis and septic shock is only partially understood. Circulating pro-inflammatory and anti-inflammatory mediators appear to participate in the complex cascade of events which leads to deranged microcirculatory function, as we know from the peak concentration hypothesis. Therapeutic trials targeting single pro-inflammatory and anti-inflammatory mediators failed to demonstrate any benefit, suggesting that the unselective removal of different mediators may be a more appropriate approach. In severe sepsis several blood purification techniques, such as continuous hemofiltration (CVVH), high volume hemofiltration (HVHF), pulse high volume hemofiltration (HVHF), plasma filtration, plasma adsorption, coupled plasma filtration adsorption (CPFA), have been proposed but such techniques appear to have both theorical as well as practical limitations. Plasma Filtration Adsorption Dialysis (PFAD) is a new extracorporeal treatment which combines different principles of blood purification in a single device. The core of this technique is a new dialyzer composed by three suitable compartments that provide specific functions. The association of multiple principles permits specific removal of molecules implicated in the pathophysiology of patient's disease and re-establishment of hydro-electrolyte, acid-base equilibrium, if renal dysfunction-failure is present. The final target of PFAD is to obtain complete purification by combining principles of physics and chemistry to remove hydrophilic and hydrophobic molecules with a very wide range of weights.

Sign in / Sign up

Export Citation Format

Share Document