scholarly journals Predictive value of urine interleukin-18 in the evolution and outcome of acute kidney injury in critically ill adult patients

2015 ◽  
Vol 114 (3) ◽  
pp. 460-468 ◽  
Author(s):  
S. Nisula ◽  
R. Yang ◽  
M. Poukkanen ◽  
S.T. Vaara ◽  
K.M. Kaukonen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Predictive Value ◽  
Kidney Injury ◽  
Adult Patients ◽  
Interleukin 18

Predictive Value of Urine Interleukin-18 in the Evolution and Outcome of Acute Kidney Injury in Critically Ill Adult Patients

2015 ◽  
Vol 59 (6) ◽  
pp. 256-257 ◽  
Author(s):  
S. Nisula ◽  
R. Yang ◽  
M. Poukkanen ◽  
S. T. Vaara ◽  
K. M. Kakounen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Predictive Value ◽  
Kidney Injury ◽  
Adult Patients ◽  
Interleukin 18

scholarly journals Clinical characteristics and predictors of mortality in critically ill influenza adult patients

2020 ◽  
Author(s):  
Jui-Chi Hsu ◽  
Ing-Kit Lee ◽  
Wen-Chi Huang ◽  
Yi-Chun Chen ◽  
Ching-Yen Tsai
Keyword(s):  
Acute Kidney Injury ◽  
Gastrointestinal Bleeding ◽  
Critically Ill ◽  
Kidney Injury ◽  
Adult Patients ◽  
Chang Gung Memorial Hospital ◽  
High Morbidity ◽  
Predictive Tool ◽  
Predictors Of Mortality ◽  
Lactate Levels

Abstract Background Severe influenza is associated with high morbidity and mortality. The aim of this study was to investigate the factors affecting the clinical outcomes of critically ill influenza patients. Methods In this retrospective study, we enrolled critically ill adult patients with influenza at the Kaohsiung Chang Gung Memorial Hospital in Taiwan. We evaluated the demographic, clinical, and laboratory findings and examined whether any of these measurements correlated with mortality. We then created an event-based algorithm as a simple predictive tool using 2 variables with statistically significant associations with mortality. Results Between 2015 and 2018, 102 critically ill influenza patients (median age, 62 years) were assessed; among them, 41 (40.1%) patients died. Of the 94 patients who received oseltamivir therapy, 68 (72.3%) began taking oseltamivir 48 hours after the onset of illness. Of the 102 patients, the major influenza-associated complications were respiratory failure (97%), pneumonia (94.1%), acute kidney injury (65.7%), adult respiratory distress syndrome (ARDS) (51%), gastrointestinal bleeding (35.3%), and bacteremia (16.7%). In the multivariate regression model, high lactate levels, ARDS, acute kidney injury, and gastrointestinal bleeding were independent predictors of mortality in critically ill influenza patients. The optimal lactate level cutoff for predicting mortality was 33 mg/dL with an area under curve of 0.728. We constructed an event-associated algorithm that included lactate and ARDS. Fifteen (75%) of 20 patients with lactate levels ≥33 mg/dL and ARDS died, compared with only 1 (7.7%) of 13 patients with normal lactate levels and without ARDS. Conclusions We identified clinical and laboratory predictors of mortality at hospital admission that could aid in the care of critically ill influenza patients. Identification of these prognostic markers could be improved to prioritize key examinations that might be useful in determining patient outcomes.

scholarly journals Assessment of urinary interleukin-18 in the early post-burn period to predict acute kidney injury of various degrees of burn patients

2022 ◽  
Author(s):  
Sharif Qamar Uddin ◽  
M. Nazrul Islam ◽  
M. Nizamuddin Chowdhury ◽  
Nizam Uddin Ahmed Chowdhury ◽  
Mohammad Zahir Uddin ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Predictive Value ◽  
Kidney Injury ◽  
Study Data ◽  
Burn Patients ◽  
Interleukin 18 ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Sensitivity Specificity

Background: Early detection of acute kidney injury (AKI) in burn-injured patients can help modify the treatment to prevent progression of acute renal failure and reduce the need for renal replacement therapy. The aim of the study was to evaluate urinary interleukin-18 in the early post-burn period to predict the AKI for the various degrees of burn patients.Methods: This prospective observational study was conducted in the department of nephrology, Dhaka medical college in collaboration with burn and plastic surgery unit of the same medical college hospital, from July 2017 to June 2018 for a period of one year. The 48 burn patients (Age>18 years) who attended in the burn unit of Dhaka medical college, Dhaka of both sexes were enrolled in this study. Data were analyzed by using SPSS 22.0. A value of p<0.05 was considered statistically significant for all tests.Results: In this study, mean age of the burn patients was 32.41±10.59 years. Male female ratio was 3.36:1. Urinary IL-18 in diagnosis of AKI showed accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 93.8%, 91.7%, 94.4%, 84.6% and 97.1% respectively. AUC for urinary IL-18 at admission was 0.968 (CI, 0.921-1.000) and AUC for serum creatinine at admission was 0.937 (CI, 0.871-1.000). Conclusions: According to Kappa value, AUC and sensitivity and specificity urinary IL-18 is a good biomarker in predicting of early AKI in burn patients.

Acute kidney injury in critically-ill adult patients with seasonal influenza infection

2017 ◽  
Vol 88 (S1) ◽  
pp. 18-21
Author(s):  
Ana Dovč ◽  
Vladimir Premru ◽  
Blaž Pečavar ◽  
Rafael Ponikvar
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Seasonal Influenza ◽  
Influenza Infection ◽  
Kidney Injury ◽  
Adult Patients

scholarly journals Urinary interleukin-18 is an acute kidney injury biomarker in critically ill children

2007 ◽  
Vol 23 (2) ◽  
pp. 566-572 ◽  
Author(s):  
K. K. Washburn ◽  
M. Zappitelli ◽  
A. A. Arikan ◽  
L. Loftis ◽  
R. Yalavarthy ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Kidney Injury ◽  
Critically Ill Children ◽  
Interleukin 18

scholarly journals Vancomycin-Associated Acute Kidney Injury in Critically Ill Adolescent and Young Adult Patients

2019 ◽  
Vol 33 (6) ◽  
pp. 749-753 ◽  
Author(s):  
William B. Hays ◽  
Emma Tillman
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Young Adult ◽  
Critically Ill ◽  
Kidney Injury ◽  
Adult Patients ◽  
Adolescent And Young Adult ◽  
Daily Dose ◽  
Vancomycin Trough ◽  
Trough Levels

Background: Risk factors for the development of vancomycin-associated acute kidney injury (AKI) have been evaluated in both pediatric and adult populations; however, no previous studies exist evaluating this in the critically ill adolescent and young adult patients. Objective: Identify the incidence of AKI and examine risk factors for the development of AKI in critically ill adolescents and young adults on vancomycin. Methods: This retrospective review evaluated the incidence of AKI in patients 15 to 25 years of age who received vancomycin, while admitted to an intensive care unit. Acute kidney injury in this population was defined as an increase in serum creatinine by 0.5 mg/dL or 50% from baseline. Patients who developed AKI were evaluated for specific risk factors compared to those who did not develop AKI. Results: A total of 50 patients (20 developed AKI) were included in the study. There was no difference in vancomycin daily dose or duration of vancomycin therapy. Maximum vancomycin trough (31.15 mg/dL vs 12.5 mg/dL, P = .006), percentage of patients with concurrent nephrotoxic medication (95% vs 60%, P = .012) and concurrent vasopressor (55% vs 23%, P = .029) were higher in those who developed AKI. Percentage of patients who underwent a procedure while on vancomycin (35% vs 6.7%, P = .021) was also higher within the AKI group. Conclusions: Vancomycin-associated AKI occurred in 40% of critically ill adolescent and young adult patients. These patients may be more likely to develop vancomycin-associated AKI if they had undergone a procedure, as well as in the presence of high vancomycin trough levels, concurrent nephrotoxic agents, and concurrent vasopressor therapy.

The Urine Protein NGAL Predicts Renal Replacement Therapy, but Not Acute Kidney Injury or 90-Day Mortality in Critically Ill Adult Patients

2014 ◽  
Vol 119 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Sara Nisula ◽  
Runkuan Yang ◽  
Kirsi-Maija Kaukonen ◽  
Suvi T. Vaara ◽  
Anne Kuitunen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Kidney Injury ◽  
Adult Patients ◽  
Urine Protein

scholarly journals Sensitivity and Spesificity of Interleukin 18 as Biomarker for Acute Kidney Injury

2018 ◽  
Vol 2 (4) ◽  
pp. 20-29
Author(s):  
Febri Jaya Gunawan ◽  
F Heru Irwanto ◽  
Andi Miarta ◽  
Theodorus Theodorus
Keyword(s):  
Acute Kidney Injury ◽  
Predictive Value ◽  
Kidney Injury ◽  
Inclusion Criteria ◽  
Interleukin 18 ◽  
Urine Level ◽  
Urine Examination ◽  
Early Biomarker ◽  
Process Studies ◽  
The Subject

Background : Incidence of AKI in intensive care unit patients reach 60-70%, and the mortality rate is about 60%.  IL-18 is a pro-inflammatory cytokine which increased in endogenous inflammation process. Studies in human showed that IL-18 concentration increased prior to AKI. Objective : The aims of this research is to determine the sensitivity and specificity of Interleukin-18 urine examination as an early biomarker for acute kidney injury. Methods : There’re total of 66 subjects who met the inclusion criteria. All the subject were checked for the IL-18 urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission. Results :The results showed in the cut-off point of 411.25 Pg/mL , urine IL-18 has a sensitivity of 54.3 % and specificity 83.9%, positive predictive value 79.17%, negative predictive value 61.9% and accuracy of 68.18% Conclusions : Our result suggest that IL-18 urine holds a promise as an early biomarker of AKI and more sensitive and specific as an early biomarker for AKI compared to creatinine serum. Key words : Acute Kidney Injury, Interleukin-18, sensitivity, spesificity

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