scholarly journals Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients

2012 ◽  
Vol 108 (3) ◽  
pp. 460-468 ◽  
Author(s):  
T. Iirola ◽  
H. Ihmsen ◽  
R. Laitio ◽  
E. Kentala ◽  
R. Aantaa ◽  
...  
Keyword(s):  
Intensive Care ◽  
Population Pharmacokinetics ◽  
Intensive Care Patients

Cardiac injury biomarkers in the critically ill

2016 ◽  
Author(s):  
Anthony S. McLean ◽  
Stephen J. Huang
Keyword(s):  
Intensive Care ◽  
Care Setting ◽  
Cardiac Injury ◽  
Cardiac Biomarkers ◽  
Intensive Care Setting ◽  
Long Term Outcomes ◽  
Cardiac Biomarker ◽  
Cardiac Stress ◽  
Intensive Care Patients

To be clinically relevant, a good cardiac biomarker should have four main characteristics. It should be organ-, disease- and stage-specific to be useful in diagnosis. Its release should be timely and its half-life should be long enough to make measurement possible and meaningful. Its serum or blood concentration should be proportional to disease severity; hence, can be used as a monitoring tool. Finally, their concentrations have implications on long-term outcomes. To date, only a handful of cardiac biomarkers have clinical relevance in the intensive care setting—cardiac troponins (as a marker of cardiac injury) and B-type natriuretic peptide (as a marker of cardiac stress) being probably the most useful. However, cautious interpretations of these biomarkers are needed in intensive care patients as several confounding factors can affect their concentrations.

scholarly journals From breaking point to breakthrough during the ICU stay: A qualitative study of family members’ experiences of long-term intensive care patients’ pathways towards survival

2018 ◽  
Vol 27 (19-20) ◽  
pp. 3630-3640 ◽  
Author(s):  
Hege S Haugdahl ◽  
Regina Eide ◽  
Ingeborg Alexandersen ◽  
Tove Engan Paulsby ◽  
Berit Stjern ◽  
...  
Keyword(s):  
Intensive Care ◽  
Qualitative Study ◽  
Family Members ◽  
Breaking Point ◽  
Intensive Care Patients ◽  
Icu Stay

Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration

2005 ◽  
Vol 45 (2) ◽  
pp. 360-371 ◽  
Author(s):  
Eleonora L. Swart ◽  
Joost de Jongh ◽  
Klaas P. Zuideveld ◽  
Meindert Danhof ◽  
Lambertus G. Thijs ◽  
...  
Keyword(s):  
Intensive Care ◽  
Population Pharmacokinetics ◽  
Continuous Venovenous Hemofiltration ◽  
Intensive Care Patients
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