scholarly journals Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirements and postoperative analgesia in children with cerebral palsy

2010 ◽  
Vol 104 (3) ◽  
pp. 344-350 ◽  
Author(s):  
H.-S. Na ◽  
J.-H. Lee ◽  
J.-Y. Hwang ◽  
J.-H. Ryu ◽  
S.-H. Han ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Postoperative Analgesia ◽  
Magnesium Sulphate ◽  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agent ◽  
Children With Cerebral Palsy

scholarly journals Efek Pemberian Magnesium Sulfat 45 Mg/kgBB terhadap Kualitas Tindakan Intubasi Endotrakeal Tanpa Obat Pelumpuh Otot dan Perubahan Respons Hemodinamik

2019 ◽  
Vol 7 (1) ◽  
pp. 48-57
Author(s):  
Fatima Fatima ◽  
Erwin Pradian ◽  
Dedi Fitri Yadi
Keyword(s):  
Endotracheal Intubation ◽  
Surgical Procedures ◽  
Magnesium Sulphate ◽  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agent ◽  
Neuromuscular Blocking Agents ◽  
Chi Square ◽  
Blocking Agents

Intubasi endotrakeal merupakan tindakan berisiko tinggi yang menghasilkan stimulasi adrenergik. Intubasi endotrakeal menggunakan obat pelumpuh otot sebagai standar baku dapat menimbulkan efek samping berupa reaksi anafilaksis dan rekurisasi pascabedah. Intubasi endotrakeal tanpa obat pelumpuh otot ditujukan untuk prosedur pembedahan yang singkat, membutuhkan identifikasi saraf, dan terdapat kontraindikasi pemberian obat pelumpuh otot. Tujuan penelitian ini mengkaji pemberian magnesium sulfat 45 mg/kgBB terhadap kualitas intubasi dan respons hemodinamik pada tindakan intubasi endotrakeal tanpa obat pelumpuh otot. Penelitian ini merupakan penelitian eksperimental secara acak buta ganda yang dilakukan secara prospektif terhadap 42 subjek penelitian yang menjalani prosedur pembedahan dengan anestesi umum di Rumah Sakit Umum Pusat Dr. Hasan Sadikin, Bandung pada bulan April–Juli 2018. Pada penelitian ini, data numerik diuji dengan uji t tidak berpasangan, sedangkan data kategorik diuji dengan uji chi-square dan Mann Whitney. Hasil penelitian menunjukkan kualitas intubasi endotrakeal tanpa obat pelumpuh otot lebih baik dengan disertai penurunan respons hemodinamik pada kelompok yang diberikan magnesium sulfat 45 mg/kgBB dibanding dengan kelompok kontrol (p<0,05). Simpulan, pemberian magnesium sulfat 45 mg/kgBB meningkatkan kualitas tindakan intubasi endotrakeal tanpa obat pelumpuh otot yang dinilai menggunakan skor Copenhagen dan menurunkan respons hemodinamik pada tindakan intubasi endotrakeal tanpa obat pelumpuhotot.Effect of 45 mg/kgBW Magnesium Sulphate on Quality of Endotracheal Intubation without Neuromuscular Blocking Agents and Change in Hemodynamic ResponsesEndotracheal intubation is a high-risk procedure that can stimulate adrenergic response. Neuromuscular blocking agent is used to facilitate endotracheal intubation but it has undesirable effects such as anaphylactic reaction and postoperative recurarization. This technique is indicated for short surgical procedures, requires nerve identification, and is contraindicated for neuromuscular blocking agent. The purpose of this study was to review the effect of 45 mg/kgBW magnesium sulphate to the quality of intubation and hemodynamic responses in endotracheal intubation without neuromuscular blocking agent. This was a prospective double blind experimental study conducted on 42 research subjects  underwent surgical procedures under general anesthesia in Dr. Hasan Sadikin General Hospital, Bandung in the period of April–July 2018. In this study, numerical data were tested by unpaired t test. Categorical data were tested by chi-square and Mann Whitney tests. The results showed that the quality of endotracheal intubation without neuromuscular blocking agent improved with minimum hemodynamic changes in the group receiving 45 mg/kgBW magnesium sulphate (p<0.05). It is concluded that 45 mg/kgBW magnesium sulphate improves intubating quality assessed using Copenhagen score and decreases hemodynamic responses to endotracheal intubation without neuromuscular blocking agents.

scholarly journals Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

2018 ◽  
Vol 129 (5) ◽  
pp. 970-988 ◽  
Author(s):  
John J. Savarese ◽  
Hiroshi Sunaga ◽  
Jeff D. McGilvra ◽  
Matthew R. Belmont ◽  
Matthew T. Murrell ◽  
...  
Keyword(s):  
Heart Rate ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Neuromuscular Blockade ◽  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agent ◽  
Duration Of Action ◽  
Short Acting ◽  
Circulatory Effects

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Structure–activity studies were performed to identify a new neuromuscular blocking agent retaining the ultra-short acting characteristics of gantacurium, including degradation and reversal by l-cysteine, but lacking its histaminoid properties in man. CW 1759-50 has emerged from this program. Methods Adduction of CW 1759-50 with l-cysteine was studied by high-performance liquid chromatography and mass spectrometry. Institutional Animal Care and Use Committee–approved comparisons of CW 1759-50 to gantacurium were performed in rhesus monkeys. ED95 for neuromuscular blockade was established. Spontaneous recovery was compared to reversal by l-cysteine in paired studies of boluses or infusions. In addition, changes in mean arterial pressure and heart rate after very large doses of 15 to 60 × ED95 were compared. Results The half-time of adduction of l-cysteine to CW 1759-50 in vitro was 2.3 min. The ED95 of CW 1759-50 was 0.069 ± 0.02 mg/kg; ED95 of gantacurium was 0.081 ± 0.05 mg/kg (P = 0.006). Duration of action (recovery to 95% twitch height after 98 to 99% blockade) was as follows: CW 1759-50, 8.2 ± 1.5 min; and gantacurium, 7.4 ± 1.9 min; (n = 8 and 9, P = 0.355). Administration of l-cysteine (30 mg/kg) shortened recovery (i.e., induced reversal) from CW 1759-50 after boluses or infusions (P always less than 0.0001). Recovery intervals (5 to 95% twitch) ranged from 6.1 to 6.7 min (and did not differ significantly) after boluses of 0.10 to 0.50 mg/kg, as well as control infusions (P = 0.426 by analysis of variance). Dose ratios comparing changes of 30% in mean arterial pressure or heart rate to ED95 for neuromuscular blockade (ED 30% Δ [mean arterial pressure or heart rate]/ED95) were higher for CW 1759-50 than for gantacurium. Conclusions CW 1759-50, similar to gantacurium, is an ultra-short acting neuromuscular blocking agent, antagonized by l-cysteine, in the monkey. The circulatory effects, however, are much reduced in comparison with gantacurium, suggesting a trial in humans.

The Interaction Between Suxamethonium and the Succeeding Non-Depolarizing Neuromuscular Blocking Agent

1991 ◽  
Vol 35 (1) ◽  
pp. 8
Author(s):  
J. SWEN ◽  
H. W. J. ROOT ◽  
A. BENCINI ◽  
J. M. KET ◽  
J. HERMANS ◽  
...  
Keyword(s):  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agent
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