scholarly journals Traumatic brain injury: assessment, resuscitation and early management

2007 ◽  
Vol 99 (1) ◽  
pp. 18-31 ◽  
Author(s):  
I.K. Moppett
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Early Management ◽  
Injury Assessment

scholarly journals Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Zeyu Wang ◽  
Haichen Wang ◽  
Ryan Becker ◽  
Joseph Rufo ◽  
Shujie Yang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Flow Cytometry ◽  
Brain Injury ◽  
Early Diagnosis ◽  
Tissue Injury ◽  
Management Strategies ◽  
Acoustic Properties ◽  
Early Management ◽  
Biomarker Analysis ◽  
Downstream Analysis

AbstractTraumatic brain injury (TBI) is a global cause of morbidity and mortality. Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available, noninvasive diagnostic biomarker. In particular, a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI (mTBI). Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue injury. By applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after TBI. Acoustofluidic isolation eliminated interference from other blood components, making it possible to detect exosomal biomarkers for TBI via flow cytometry. Flow cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma, indicating the potential of using circulating exosomes for the rapid diagnosis of TBI. Elevated levels of TBI biomarkers were only detected in the samples separated via acoustofluidics; no changes were observed in the analysis of the raw plasma sample. This finding demonstrated the necessity of sample purification prior to exosomal biomarker analysis. Since acoustofluidic exosome separation can easily be integrated with downstream analysis methods, it shows great potential for improving early diagnosis and treatment decisions associated with TBI.

scholarly journals Early management of traumatic brain injury in a Tertiary hospital in Central Kenya: A clinical audit

2016 ◽  
Vol 7 (01) ◽  
pp. 97-101 ◽  
Author(s):  
Clifford Chacha Mwita ◽  
Johnstone Muthoka ◽  
Stephen Maina ◽  
Phillip Mulingwa ◽  
Samson Gwer
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Road Traffic ◽  
Clinical Audit ◽  
Tertiary Hospital ◽  
Poor Compliance ◽  
Sub Saharan Africa ◽  
Neurosurgical Procedures ◽  
Early Management ◽  
Central Kenya

ABSTRACT Background: Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is mostly attributed to road traffic accidents in resource-poor areas. However, access to neurosurgical care is poor in these settings and patients in need of neurosurgical procedures are often managed by general practitioners or surgeons. Materials and Methods: A retrospective clinical audit of the initial management of patients with TBI in Thika Level 5 Hospital (TL5H), a Tertiary Hospital in Central Kenya. Seventeen audit criteria divided into five clinical domains were identified and patient case notes reviewed for compliance with each criterion. Data were analyzed separately for those below 13 years owing to differences in response to brain trauma in those below this age. Results: Overall, there was poor compliance with audit criteria in both groups. Among those below 13 years of age, only 3 out of 17 criteria achieved compliance and 4 out of 17 criteria achieved compliance for those above 13 years of age. Assessment for the need for a cervical radiograph (7.1% and 8.8% compliance) and administration of oxygen (21.4% and 20.6% compliance) had the worst performance in both groups. Conclusion: Poor compliance to audit criteria indicates the low quality of care for patients with TBI in TL5H. Quality improvement strategies with follow-up audits are needed to improve care. There is a need to develop and enforce evidence-based protocols and guidelines for use in the management of patients with TBI in sub-Saharan Africa.

Early management of severe traumatic brain injury

The Lancet ◽  
2012 ◽  
Vol 380 (9847) ◽  
pp. 1088-1098 ◽  
Author(s):  
Jeffrey V Rosenfeld ◽  
Andrew I Maas ◽  
Peter Bragge ◽  
M Cristina Morganti-Kossmann ◽  
Geoffrey T Manley ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Early Management

Cytotoxic and vasogenic cerebral oedema in traumatic brain injury: Assessment with FLAIR and DWI imaging

Brain Injury ◽  
2014 ◽  
Vol 28 (12) ◽  
pp. 1602-1609 ◽  
Author(s):  
Anne M. Hudak ◽  
Lifang Peng ◽  
Carlos Marquez de la Plata ◽  
John Thottakara ◽  
Carol Moore ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cerebral Oedema ◽  
Injury Assessment

scholarly journals Utility of recently-developed questionnaires in mild traumatic brain injury assessment

1997 ◽  
Vol 12 (4) ◽  
pp. 380-381
Author(s):  
C. Paniak ◽  
G. Toller-Lobe ◽  
J. Nagy ◽  
A. Stock ◽  
M. I. Goltz
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Injury Assessment

scholarly journals VERBAL MEMORY DEFICIT FOLLOWING TRAUMATIC BRAIN INJURY: ASSESSMENT USING ADVANCED MRI METHODS

Neurology ◽  
2008 ◽  
Vol 71 (15) ◽  
pp. 1199-1201 ◽  
Author(s):  
C. L. MacDonald ◽  
N. Schwarze ◽  
S. N. Vaishnavi ◽  
A. A. Epstein ◽  
A. Z. Snyder ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Verbal Memory ◽  
Memory Deficit ◽  
Injury Assessment
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