scholarly journals Codeine phosphate in paediatric medicine

2001 ◽  
Vol 86 (3) ◽  
pp. 413-421 ◽  
Author(s):  
D.G. Williams ◽  
D.J. Hatch ◽  
R.F. Howard
Keyword(s):  
Codeine Phosphate ◽  
Paediatric Medicine

scholarly journals Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Codeine Phosphate and Chlorpheniramine Maleate from Their Combined Liquid Dosage Form

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ramakrishna Kommana ◽  
Praveen Basappa
Keyword(s):  
Limit Of Detection ◽  
Degradation Products ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Forced Degradation ◽  
Codeine Phosphate ◽  
Chlorpheniramine Maleate ◽  
Combination Drug ◽  
Stability Indicating ◽  
Rp Hplc

The present paper describes the development of quick stability indicating RP-HPLC method for the simultaneous estimation of codeine phosphate and chlorpheniramine maleate in the presence of its degradation products, generated from forced degradation studies. The developed method separates codeine phosphate and chlorpheniramine maleate in impurities/degradation products. Codeine phosphate and chlorpheniramine maleate and their combination drug product were exposed to acid, base, oxidation, dry heat, and photolytic stress conditions, and the stressed samples were analysed by proposed method. The proposed HPLC method utilizes the Shimadzu HPLC system on a Phenomenex C18 column (, 5 μ) using a mixture of 1% o-phosphoric acid in water : acetonitrile : methanol (78 : 10 : 12) mobile phase with pH adjusted to 3.0 in an isocratic elution mode at a flow rate of 1 mL/min, at 23°C with a load of 20 μL. The detection was carried out at 254 nm. The retention time of codeine phosphate and chlorpheniramine maleate was found to be around 3.47 min and 9.45 min, respectively. The method has been validated with respect to linearity, robustness, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). The developed validated stability indicating HPLC method was found to be simple, accurate, and reproducible for the determination of instability of these drugs in bulk and commercial products.

A Treatment for the Acute Migraine Attack

1987 ◽  
Vol 15 (2) ◽  
pp. 71-75 ◽  
Author(s):  
E. I. Adam
Keyword(s):  
Acute Attack ◽  
Response To Treatment ◽  
Codeine Phosphate ◽  
Double Blind ◽  
Recent Onset ◽  
Randomized Crossover Trial ◽  
History Of ◽  
Specific Factors ◽  
Acute Attacks ◽  
Acute Migraine Attack

A compound analgesic/anti-emetic formulation was significantly effective in reducing the severity of acute attacks of migraine, in a double-blind, randomized, crossover trial of 34 patients referred to a migraine clinic. The preparation contained paracetamol (acetaminophen) 500 mg, codeine phosphate 8 mg, buclizine hydrochloride 6.25 mg and dioctyl sodium sulphosuccinate 10 mg. The dosage was two tablets taken as early as possible in the acute attack. No specific factors could be identified which influenced response to treatment Patients with a long history of migraine (more than 10 years) responded as well as those with a recent onset of the condition.

A Pain Clinic Assessment of Syndol in Headache

1973 ◽  
Vol 1 (6) ◽  
pp. 567-572
Author(s):  
B T Marsh ◽  
A T Mennie ◽  
J Samarasinghe ◽  
D S Robbie
Keyword(s):  
Multiple Dose ◽  
Tension Headache ◽  
Pain Clinic ◽  
Common Side Effect ◽  
Codeine Phosphate ◽  
Analgesic Action ◽  
Multiple Dose Study ◽  
Analgesic Medication ◽  
Dose Study ◽  
Royal Marsden Hospital

Syndol, a formulation containing paracetamol, codeine phosphate, caffeine and doxylamine succinate, was evaluated in the Pain Clinic Unit of the Royal Marsden Hospital. In a single dose pilot study with eleven patients, 81% had speedy and effective relief from their headache for up to four hours. In a multiple-dose study over one week with twenty-four patients, seventeen patients ( 85%) had a 50% or greater relief from pain. No abnormal haematological or biochemical results were seen in this group of patients. Over 70% of these patients suffered from headaches in the afternoon and evening, with a peak incidence between 9 pm and midnight. This may indicate a separate sub-group of patients with tension headache who should do well on sedative-analgesic medication. The most common side-effect was drowsiness and sedation reported by fourteen patients ( 63%). The sedative-analgesic action of Syndol was well recognized by the patient and premedication on retiring to bed proved useful in those patients awoken during the night or waking in the morning with Tension Headache.

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