scholarly journals Effect of cardiopulmonary bypass on serum procalcitonin and C-reactive protein concentrations

1999 ◽  
Vol 83 (4) ◽  
pp. 602-607 ◽  
Author(s):  
A Aouifi ◽  
V Piriou ◽  
P Blanc ◽  
H Bouvier ◽  
O Bastien ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-Reactive Protein and Cardiopulmonary Bypass in Infants under 5 Kilograms

1991 ◽  
Vol 28 (1) ◽  
pp. 109-110 ◽  
Author(s):  
I. M. Mitchell ◽  
J. C. S. Pollock ◽  
M. P. G. Jamieson ◽  
S. F. O. Donaghey ◽  
R. D. Paton ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
C Reactive Protein ◽  
Reactive Protein

Post-operative kinetics of C-reactive protein to distinguish between bacterial infection and systemic inflammation in infants after cardiopulmonary bypass surgery: the early and the late period

2021 ◽  
pp. 1-8
Author(s):  
Hanna Renk ◽  
David Grosse ◽  
Sarah Schober ◽  
Christian Schlensak ◽  
Michael Hofbeck ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Bacterial Infection ◽  
Congenital Heart ◽  
Bypass Surgery ◽  
Heart Surgery ◽  
Congenital Heart Surgery ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Post Operative Period ◽  
Kinetics Of

Abstract Objectives: Differentiation between post-operative inflammation and bacterial infection remains an important issue in infants following congenital heart surgery. We primarily assessed kinetics and predictive value of C-reactive protein for bacterial infection in the early (days 0–4) and late (days 5–28) period after cardiopulmonary bypass surgery. Secondary objectives were frequency, type, and timing of post-operative infection related to the risk adjustment for congenital heart surgery score. Methods: This 3-year single-centre retrospective cohort study in a paediatric cardiac ICU analysed 191 infants accounting for 235 episodes of CPBP surgery. Primary outcome was kinetics of CRP in the first 28 days after CPBP surgery in infected and non-infected patients. Results: We observed 22 infectious episodes in the early and 34 in the late post-operative period. CRP kinetics in the early post-operative period did not accurately differentiate between infected and non-infected patients. In the late post-operative period, infected infants displayed significantly higher CRP values with a median of 7.91 (1.64–22.02) and 6.92 mg/dl (1.92–19.65) on days 2 and 3 compared to 4.02 (1.99–15.9) and 3.72 mg/dl (1.08–9.72) in the non-infection group. Combining CRP on days 2 and 3 after suspicion of infection revealed a cut-off of 9.47 mg/L with an acceptable predictive accuracy of 76%. Conclusions: In neonates and infants, CRP kinetics is not useful to predict infection in the first 72 hours after CPBP surgery due to the inflammatory response. However, in the late post-operative period, CRP is a valuable adjunctive diagnostic test in conjunction with clinical presentation and microbiological diagnostics.

scholarly journals Complement (C3, C4) and C-reactive Protein Responses to Cardiopulmonary Bypass and Protamine Administration

1993 ◽  
Vol 21 (1) ◽  
pp. 50-55 ◽  
Author(s):  
M. Tulunay ◽  
S. Demiralp ◽  
S. Tastan ◽  
H. Akalin ◽  
U. Ozyurda ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Complement System ◽  
Complement Activation ◽  
Heart Surgery ◽  
Tissue Injury ◽  
Open Heart Surgery ◽  
Complement C3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Protamine Administration

Complement activation has been deemed responsible for the damaging effects of cardiopulmonary bypass (CPB) in patients undergoing open heart surgery. We studied C3, C4 and C-reactive protein (CRP) in 22 patients undergoing CPB. In Group 1 (11 patients), protamine was given intravenously and in Group 2 (11 patients), via the aortic root after CPB. Significant decreases were observed in C3 and C4 during CPB in both groups indicating complement activation primarily by the classic pathway. Protamine did not lead to further activation of the complement system. In both groups, C3 levels gradually returned toward baseline within 24 hours but C4 levels were still lower than baseline 24 hours postoperatively. CPB and protamine administration did not cause any significant changes in CRP levels, but CRP increased abruptly 24 hours after operation. Although activation of complement system during CPB is expected to invoke an acute phase response, we conclude that this period is not long enough to induce an increased production of CRP in response to tissue injury or inflammation.

Kinetics of procalcitonin, interleukin 6 and C-reactive protein after cardiopulmonary-bypass in children

2003 ◽  
Vol 13 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Maurice Beghetti ◽  
Peter C. Rimensberger ◽  
Afksendiyos Kalangos ◽  
Walid Habre ◽  
Alain Gervaix
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Interleukin 6 ◽  
Early Recognition ◽  
P Value ◽  
Specific Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Valuable Marker ◽  
R Value

Cardiopulmonary bypass induces a generalized inflammatory response, with fever and leukocytes, which is difficult to differentiate from an infection. Recently, procalcitonin has been proposed as an early and specific marker of bacterial infection. The influence of cardiopulmonary bypass on production of procalcitonin, therefore, must be assessed before considering this molecule as a valuable marker of infection after cardiac surgery in children. With this in mind, we measured levels of procalcitonin, interleukin 6, and C-reactive protein before and 6 h, 1, 3 and 5 days after cardiopulmonary bypass, in 25 children undergoing cardiac surgery. Cardiopulmonary-bypass induced a transient increase in procalcitonin, with a peak at 24 h, with a median of 1.13 μg/l, a 25th and 75th interquartile of 0.68–2.25, and a p value of less than 0.001. The value had returned to normal in the majority of the children by the third day after surgery. Peak values correlated with the duration of cardiopulmonary-bypass, with a r-value of 0.58 and a p value of 0.003; cross-clamp time, with a r-value of 0.62 and a p value of 0.001; days of mechanical ventilation, with a r-value of 0.62 and a p value of 0.001; and days of stay in intensive care, with a r-value of 0.68, and a p value of 0.0003. The value returned to normal after 3 days in 83% of the patients. Levels of interleukin 6 and C-reactive protein also increased significantly after surgery, and remained elevated for up to 5 days.Thus, in contrast to other markers, levels of procalcitonin in the serum are only slightly and transiently influenced by cardiopulmonary bypass, and may prove to be useful in the early recognition of an infection subsequent to cardiopulmonary bypass.

scholarly journals Procalcitonin is a Better Biomarker than C-Reactive Protein in Newborns Undergoing Cardiac Surgery: The Prokineca Study

2016 ◽  
Vol 11 ◽  
pp. BMI.S40658 ◽  
Author(s):  
Sara Bobillo Pérez ◽  
Javier Rodríguez-Fanjul ◽  
Iolanda Jordan García ◽  
Julio Moreno Hernando ◽  
Martín Iriondo Sanz
Keyword(s):  
Cardiopulmonary Bypass ◽  
Neonatal Intensive Care ◽  
Area Under The Curve ◽  
C Reactive Protein ◽  
Sepsis Diagnosis ◽  
Reactive Protein ◽  
Optimal Area ◽  
A Prospective Study ◽  
Kinetics Of ◽  
Better Than

Objectives To assess the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) in newborns after cardiothoracic surgery (CS), with and without cardiopulmonary bypass, and to assess whether PCT was better than CRP in identifying sepsis in the first 72 hours after CS. Patients and Methods This is a prospective study of newborns admitted to the neonatal intensive care unit after CS. Interventions PCT and CRP were sequentially drawn 2 hours before surgery and at 0, 12, 24, 48, and 72 hours after surgery. Results A total of 65 patients were recruited, of which 14 were excluded because of complications. We compared the kinetics of PCT and CRP after CS in bypass and non-bypass groups without sepsis; there were no differences in the PCT values at any time (24 hours, P = 0.564; 48 hours, P = 0.117; 72 hours, P = 0.076). Thirty-five patients needed bypass, of whom four were septic (11.4%). Significant differences were detected in the PCT values on comparing the septic group to the nonseptic group at 48 hours after cardiopulmonary bypass ( P= 0.018). No differences were detected in the CRP values in these groups. A suitable cutoff for sepsis diagnosis at 48 hours following bypass would be 5 ng/mL, with optimal area under the curve of 0.867 (confidence interval 0.709–0.958), P< 0.0001, and sensitivity and specificity of 87.5% (29.6–99.7) and 72.6% (53.5–86.4), respectively. Conclusions This is a preliminary study but PCT seems to be a good biomarker in newborns after CS. Values over 5 ng/mL at 48 hours after CS should alert physicians to the high risk of sepsis in these patients.

scholarly journals Role of Neopterin, C-Reactive Protein and Myeloperoxidase in Patients Undergoing Cardiopulmonary Bypass

2010 ◽  
Vol 19 (6) ◽  
pp. 479-484 ◽  
Author(s):  
Lokman Ayaz ◽  
Ali Unlu ◽  
Nehir Sucu ◽  
Lulufer Tamer ◽  
Ugur Atik ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
C Reactive Protein ◽  
Reactive Protein
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